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Activity And Nature Of Plasminogen Activators Associated With The Casein Micelle, B. Ismail, L. H. Choi, Lilian M. Were, S. S. Nielsen
Activity And Nature Of Plasminogen Activators Associated With The Casein Micelle, B. Ismail, L. H. Choi, Lilian M. Were, S. S. Nielsen
Food Science Faculty Articles and Research
In fresh milk, plasminogen, the zymogen form of plasmin (PL), is the predominant form. Therefore, plasminogen activators (PA) can contribute significantly to PL activity in milk. Both tissue-type PA (tPA) and urokinase-type PA (uPA) exist in milk; however, contradictory findings have been reported for which type of PA is most closely associated with the casein micelles. Little is known about the factors that might lead to variations in the individual activities of the PA. The objective of this work was therefore to investigate possible factors that might affect the association of tPA and uPA with the casein micelle and their …