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Articles 1 - 14 of 14
Full-Text Articles in Entire DC Network
Event-Related Potential Evidence For Multiple Causes Of The Revelation Effect, P. Andrew Leynes, Joshua Landau, Jessica Walker, Richard J. Addante
Event-Related Potential Evidence For Multiple Causes Of The Revelation Effect, P. Andrew Leynes, Joshua Landau, Jessica Walker, Richard J. Addante
Psychology Faculty Publications
Asking people to discover the identity of a recognition test probe immediately before making a recognition judgment increases the probability of an old judgment. To inform theories of this “revelation effect,” event-related potentials (ERPs) were recorded for revealed and intact test items across two experiments. In Experiment 1, we used a revelation effect paradigm where half of the test probes were presented as anagrams (i.e., a related task) and the other items were presented intact. The pattern of ERP results from this experiment suggested that revealing an item decreases initial familiarity levels and caused the revealed items to elicit similar …
Deletion Of Bax Eliminates Sex Differences In The Mouse Forebrain, Nancy Forger, Greta J. Rosen, Elizabeth M. Waters, Dena A. Jacob, Richard B. Simerly, Geert De Vries
Deletion Of Bax Eliminates Sex Differences In The Mouse Forebrain, Nancy Forger, Greta J. Rosen, Elizabeth M. Waters, Dena A. Jacob, Richard B. Simerly, Geert De Vries
Neuroscience Institute Faculty Publications
Several of the best-studied sex differences in the mammalian brain are ascribed to the hormonal control of cell death. This conclusion is based primarily on correlations between pyknotic cell counts in development and counts of mature neurons in adulthood; the molecular mechanisms of hormone-regulated, sexually dimorphic cell death are unknown. We asked whether Bax, a member of the Bcl-2 family of proteins that is required for cell death in many developing neurons, might be essential for sex differences in neuron number. We compared Bax knockout mice and their WT siblings, focusing on two regions of the mouse forebrain that show …
Human Stick Balancing: Tuning Lèvy Flights To Improve Balance Control, Juan Luis Cabrera, John Milton
Human Stick Balancing: Tuning Lèvy Flights To Improve Balance Control, Juan Luis Cabrera, John Milton
WM Keck Science Faculty Papers
State-dependent, or parametric, noise is an essential component of the neural control mechanism for stick balancing at the fingertip. High-speed motion analysis in three dimensions demonstrates that the controlling movements made by the fingertip during stick balancing can be described by a Lévy flight. The Lévy index, , is approximately 0.9; a value close to optimal for a random search. With increased skill, the index does not change. However, the tails of the Lévy distribution become broader. These observations suggest a Lévy flight that is truncated by the properties of the nervous and musculoskeletal system; the truncation decreasing as skill …
Synaptic Transformations Underlying Highly Selective Auditory Representations Of Learned Birdsong, Melissa J. Coleman, Richard Mooney
Synaptic Transformations Underlying Highly Selective Auditory Representations Of Learned Birdsong, Melissa J. Coleman, Richard Mooney
WM Keck Science Faculty Papers
Stimulus-specific neuronal responses are a striking characteristic of several sensory systems, although the synaptic mechanisms underlying their generation are not well understood. The songbird nucleus HVC (used here as a proper name) contains projection neurons (PNs) that fire temporally sparse bursts of action potentials to playback of the bird's own song (BOS) but are essentially silent when presented with other acoustical stimuli. To understand how such remarkable stimulus specificity emerges, it is necessary to compare the auditory-evoked responsiveness of the afferents of HVC with synaptic responses in identified HVC neurons. We found that inactivating the interfacial nucleus of the nidopallium …
Sexually Dimorphic Effects Of Prenatal Stress On Cognition, Hormonal Responses, And Central Neurotransmitters, Rachel E. Bowman, Neil J. Maclusky, Yessenia Sarmiento, Maya Frankfurt, Marisa Gordon, Victoria N. Luine
Sexually Dimorphic Effects Of Prenatal Stress On Cognition, Hormonal Responses, And Central Neurotransmitters, Rachel E. Bowman, Neil J. Maclusky, Yessenia Sarmiento, Maya Frankfurt, Marisa Gordon, Victoria N. Luine
Psychology Faculty Publications
Exposure to stress during gestation results in physiological and behavioral alterations that persist into adulthood. This study examined the effects of prenatal stress on the postnatal expression of sexually differentiated cognitive, hormonal, and neurochemical profiles in male and female rats. Pregnant dams were subjected to restraint stress three times daily for 45 min during d 14-21 of pregnancy. The offspring of control and prenatally stressed dams were tested for anxiety-related and cognitive behaviors, stress and gonadal steroid hormone levels, as well as monoamines and metabolite levels in selected brain regions. Postnatal testosterone levels (measured at 1 and 5 d) did …
The Great Escape: Phosphorylation Of Ena/Vasp By Pka Promotes Filopodial Formation, Timothy M. Gomez, Estuardo Robles
The Great Escape: Phosphorylation Of Ena/Vasp By Pka Promotes Filopodial Formation, Timothy M. Gomez, Estuardo Robles
Neuroscience: Faculty Publications
The Ena/VASP family of proteins consists of adaptor molecules that localize to subcellular sites of actin polymerization. The role of Ena/VASP proteins in the regulation of cell motility and axon outgrowth has been controversial. Recently, these proteins have been proposed to function as "anticapping" factors, which may have differential effects on filopodial versus lammelipodial actin-based protrusions. A study by Lebrand et al. in this issue of Neuron supports this model and identifies PKA as a key regulator of Ena/VASP function downstream of the chemoattractant Netrin.
Measuring Salivary Cortisol In The Behavioral Neuroscience Laboratory, Brian A. Kalman, Ruth E. Grahn
Measuring Salivary Cortisol In The Behavioral Neuroscience Laboratory, Brian A. Kalman, Ruth E. Grahn
Psychology Faculty Publications
As instructors who teach laboratory courses in biological psychology/behavioral neuroscience, we have often been at a loss to find appropriate experiments where students are able to play both the role of experimenter and subject. The difficulty arises because there are few biological parameters representing CNS activity that can ethically be examined in human participants. As a result, the go-to experiments that allow students to act as both experimenter and subject tend to be electrophysiological in nature (e.g., EEG, GSR, etc.). It was our desire to create a laboratory module that would allow students to collect and analyze a biochemical measure …
Collaborative Research: A Dynamic Atlas Of The Cricket Cercal Sensory System, Sharon M. Crook
Collaborative Research: A Dynamic Atlas Of The Cricket Cercal Sensory System, Sharon M. Crook
University of Maine Office of Research Administration: Grant Reports
A fundamental question in neuroscience is how natural sensory stimuli are encoded for information handling by the brain. Invertebrate animals often offer systems that are in some ways simpler than those of mammals, and including such features as identifiable single cells in networks of relatively few numbers. This collaborative project exploits a sensory system called the cercal system of the cricket, in which small appendages on the rear of the body contain fine hairs that are used to detect, identify and localize behaviorally relevant air current movements, such as those produced by a predator. The input from roughly 2000 receptor …
Loss-Of-Function Analysis Of Epha Receptors In Retinotectal Mapping, David Feldheim, Masaru Nakamoto, Miriam Osterfield, Nicholas Gale, Thomas Dechiara, Rajat Rohatgi, George Yancopoulos, John Flanagan
Loss-Of-Function Analysis Of Epha Receptors In Retinotectal Mapping, David Feldheim, Masaru Nakamoto, Miriam Osterfield, Nicholas Gale, Thomas Dechiara, Rajat Rohatgi, George Yancopoulos, John Flanagan
Biology Faculty Publications
EphA tyrosine kinases are thought to act as topographically specific receptors in the well-characterized projection map from the retina to the tectum. Here, we describe a loss-of-function analysis of EphA receptors in retinotectal mapping. Expressing patches of a cytoplasmically truncated EphA3 receptor in chick retina caused temporal axons to have reduced responsiveness to posterior tectal repellent activity in vitro and to shift more posteriorly within the map in vivo . A gene disruption of mouse EphA5, replacing the intracellular domain with beta-galactosidase, reduced in vitro responsiveness of temporal axons to posterior target membranes. It also caused map abnormalities in vivo …
Changes In Gdnf Protein Content Of Skeletal Muscle Following Involuntary Exercise Are Long Lived, Kyle R. Kinnell, Monica J. Czarnopys, John Spitsbergen
Changes In Gdnf Protein Content Of Skeletal Muscle Following Involuntary Exercise Are Long Lived, Kyle R. Kinnell, Monica J. Czarnopys, John Spitsbergen
Biological Sciences Faculty and Graduate Student Research
Glial-cell line derived neurotrophic factor (GDNF) is a neurotrophic factor produced by skeletal muscle. GDNF has been shown to be potent survival factor for motor neurons. We have previously shown that GDNF content in skeletal muscle is altered following exercise and GDNF levels 24 hours after the last bout of exercise are significantly different than those measured immediately after exercise. We sought to determine how long after exercise do GDNF protein levels remain altered. We removed extensor digitorum longus (EDL) and Soleus (SOL), 24 hr, 72 hr and 1 week following the last bout of involuntary exercise. Muscles were processed …
Neuroplasticity And Functional Recovery: Training Models And Compensatory Strategies In Music Therapy, Felicity Baker, Edward A. Roth
Neuroplasticity And Functional Recovery: Training Models And Compensatory Strategies In Music Therapy, Felicity Baker, Edward A. Roth
BRAIN Lab Research
New research developments in the recovery of function following neurological trauma as well as basic and applied research relevant to music perception and production, seem to point to the suggestion that specific music therapy interventions that directly address the restoration of function as opposed to developing compensatory mechanisms, in certain circumstances, may now be a more appropriate treatment approach. We will address the issue of appropriate timing for the introduction of each strategy and discuss potential outcomes of each approach. As one might imagine, much of this research is published in the neurological journals, which music therapists may not regularly …
'Listen, Rama’S Wife!’: Maithil Women’S Perspectives And, A.M. Leaver, Andrea Halpern
'Listen, Rama’S Wife!’: Maithil Women’S Perspectives And, A.M. Leaver, Andrea Halpern
Faculty Journal Articles
The two modes most widely used in Western music today convey opposite moods—a distinction that nonmusicians and even young children are able to make. However, the current studies provide evidence that, despite a strong link between mode and affect, mode perception is problematic. Nonmusicians found mode discrimination to be harder than discrimination of other melodic features, and they were not able to accurately classify major and minor melodies with these labels. Although nonmusicians were able to classify major and minor melodies using affective labels, they performed at chance in mode discrimination. Training, in the form of short lessons given to …
Visual Enhancing Of Tactile Perception In The Posterior Parietal Cortex, Tony Ro, Ruth Wallace, Judith Hagedorn, Alessandro Farnè, Elizabeth Pienkos
Visual Enhancing Of Tactile Perception In The Posterior Parietal Cortex, Tony Ro, Ruth Wallace, Judith Hagedorn, Alessandro Farnè, Elizabeth Pienkos
Publications and Research
The visual modality typically dominates over our other senses. Here we show that after inducing an extreme conflict in the left hand between vision of touch (present) and the feeling of touch (absent), sensitivity to touch increases for several minutes after the conflict. Transcranial magnetic stimulation of the posterior parietal cortex after this conflict not only eliminated the enduring visual enhancement of touch, but also impaired normal tactile perception. This latter finding demonstrates a direct role of the parietal lobe in modulating tactile perception as a result of the conflict between these senses. These results provide evidence for visual-to-tactile perceptual …
Behavioral And Neural Correlates Of Perceived And Imagined Musical Timbre, Andrea Halpern, R.J. Zattore, M. Bouffard, J.A. Johnson
Behavioral And Neural Correlates Of Perceived And Imagined Musical Timbre, Andrea Halpern, R.J. Zattore, M. Bouffard, J.A. Johnson
Faculty Journal Articles
The generality of findings implicating secondary auditory areas in auditory imagery was tested by using a timbre imagery task with fMRI. Another aim was to test whether activity in supplementary motor area (SMA) seen in prior studies might have been related to subvocalization. Participants with moderate musical background were scanned while making similarity judgments about the timbre of heard or imagined musical instrument sounds. The critical control condition was a visual imagery task. The pattern of judgments in perceived and imagined conditions was similar, suggesting that perception and imagery access similar cognitive representations of timbre. As expected, judgments of heard …