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Long-Term Effects Of Early Social Isolation In Macaca Mulatta: Changes In Dopamine Receptor Function Following Apomorphine Challenge, Mark H. Lewis, John P. Gluck, Tom L. Beauchamp, Michael F. Keresztury, Richard B. Mailman
Long-Term Effects Of Early Social Isolation In Macaca Mulatta: Changes In Dopamine Receptor Function Following Apomorphine Challenge, Mark H. Lewis, John P. Gluck, Tom L. Beauchamp, Michael F. Keresztury, Richard B. Mailman
John P. Gluck, PhD
The hypothesis that early social isolation results in long-term alterations in dopamine receptor sensitivity was tested using older adult rhesus monkeys. Isolated and control monkeys were challenged with apomorphine (0.1 and 0.3 mg/kg), and the drug effects on spontaneous blink rate, stereotyped behavior, and self-injurious behavior were quantified using observational measures. Monoamine metabolites were quantified from cisternal CSF by HPLC-EC, prior to pharmacological challenge. Isolated and control monkeys did not differ in CSF concentrations of HVA, 5-HIAA, or MHPG. At the higher dose, apomorphine significantly increased the rate of blinking, the occurrence of whole-body stereotypies, and the intensity of stereotyped …
Cerebrospinal Fluid Dynamics In The Cervical Spine: Importance Of Fine Anatomical Structures, S. Pahlavian, T. Yiallourou, R. Tubbs, A. Bunck, M. Goodin, Francis Loth, M. Raisee, Bryn Martin
Cerebrospinal Fluid Dynamics In The Cervical Spine: Importance Of Fine Anatomical Structures, S. Pahlavian, T. Yiallourou, R. Tubbs, A. Bunck, M. Goodin, Francis Loth, M. Raisee, Bryn Martin
Dr. Bryn Martin
No abstract provided.
Syringomyelia: A Review Of The Biomechanics, N. Elliott, C. Bertram, Bryn Martin, A. Brodbelt
Syringomyelia: A Review Of The Biomechanics, N. Elliott, C. Bertram, Bryn Martin, A. Brodbelt
Dr. Bryn Martin
Syringomyelia is a neurological disorder caused by the development of one or more macroscopic fluid-filled cavities in the spinal cord. While the aetiology remains uncertain, hydrodynamics appear to play a role. This has led to the involvement of engineers, who have modelled the system in silico and on the bench. In the process, hypotheses from the neurosurgical literature have been tested, and others generated, while aspects of the system mechanics have been clarified. The spinal cord is surrounded by cerebrospinal fluid (CSF) which is subject both to the periodic excitation of CSF expelled from the head with each heartbeat, and …
Tnf Polymorphisms In Alzheimer Disease And Functional Implications On Csf Beta-Amyloid Levels, Simon Laws, Robert Perneczky, Stefan Wagenpfeil, Ulrich Muller, Hans Forstl, Ralph Martins, Alexander Kurz, Matthias Riemenschneider
Tnf Polymorphisms In Alzheimer Disease And Functional Implications On Csf Beta-Amyloid Levels, Simon Laws, Robert Perneczky, Stefan Wagenpfeil, Ulrich Muller, Hans Forstl, Ralph Martins, Alexander Kurz, Matthias Riemenschneider
Simon Laws
Alzheimer disease (AD), vascular dementia, and stroke are all associated with inflammation though their respective initiating factors differ. Recently a polymorphism in the proinflammatory cytokine tumor necrosis factor (TNF), in association with apolipoprotein E (APOE), was reported to increase AD risk. Two SNPs, rs1799724 (–850C>T; NT_007592.14:g.22400733C>T) and rs1800629 (–308G>A; [NT_007592.14:g.22401282G>A]), and the APOE polymorphism were genotyped in 506 patients with sporadic AD and in 277 cognitively healthy controls. In a subset of 90 individuals we also investigated whether these SNPs exerted any functional effects on cerebrospinal fluid (CSF) beta-amyloid (Aβ) levels. The frequency of the rs1799724 …