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Medicine and Health Sciences

1998

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Timp-1 Expression Is Increased In X-Linked Progressive Retinal Atrophy Despite Its Exclusion As A Candidate Gene, Caroline Zeiss, Gregory M. Acland, Gustavo D. Aguirre, Kunal Ray Dec 1998

Timp-1 Expression Is Increased In X-Linked Progressive Retinal Atrophy Despite Its Exclusion As A Candidate Gene, Caroline Zeiss, Gregory M. Acland, Gustavo D. Aguirre, Kunal Ray

Gustavo D. Aguirre, VMD, PhD

X-linked progressive retinal atrophy (XLPRA) is the only known natural animal model for X-linked retinitis pigmentosa (XLRP), a blinding disorder in man. The tissue inhibitor metalloproteinase 1 gene (TIMP-1), present in close proximity to one of the two XLRPloci, was tested as a candidate for XLPRA, by first characterizing the cDNA and gene from a normal dog. The cloned canine TIMP-1 cDNA is predicted to encode a protein of 207 amino acids with 66–83% identity in the deduced aa sequence with homologous mammalian genes. No sequence difference in the coding sequence of  …


D'Oh! An Analysis Of The Medical Care Provided To The Family Of Homer J. Simpson, Robert Patterson, Charles Weijer Dec 1998

D'Oh! An Analysis Of The Medical Care Provided To The Family Of Homer J. Simpson, Robert Patterson, Charles Weijer

Charles Weijer

No abstract provided.


Sunday Times: Pig Blood May Replace Human Transfusions, Nick Newman, Cherry Norton Dec 1998

Sunday Times: Pig Blood May Replace Human Transfusions, Nick Newman, Cherry Norton

Vivian C. McAlister

Cartoon and news article regarding xenotransfusion research by Dr Vivian McAlister


How Pigs' Blood Could Save Lives: Canadian Study Could End Need For Human Donations, Allison Hanes, Randy Boswell Dec 1998

How Pigs' Blood Could Save Lives: Canadian Study Could End Need For Human Donations, Allison Hanes, Randy Boswell

Vivian C. McAlister

Dr. [Vivian McAlister] agrees that the risk of inter-species infection remains a key obstacle to producing safe pigblood products for people: "The most important thing is that the safety of this sort of thing has to be thoroughly assessed before any implementation. We're dealing more with the immunological barriers, not the infectious disease," he says of his research. "However, if the infectious risks were overcome, or they were understood, an animal source for blood donation" could revolutionize blood-supply services around the world, he says. Currently mired in a depressed pork market that is threatening to put many producers out of …


Lower Lip Numbness Due To Peri-Radicular Dental Infection, Wei Cheong Ngeow Dec 1998

Lower Lip Numbness Due To Peri-Radicular Dental Infection, Wei Cheong Ngeow

Wei Cheong Ngeow

Lower lip numbness has always been a sinister symptom. Much has been written about it being the sole symptom of pathological lesions and metastatic tumours in the mandible. It may also be a symptom of manifestations of certain systemic disorders. A case of lower lip numbness resulting from the compression of the mental nerve by a peri-radicular abscess is presented because of the unusual nature of this spread of infection.


Tropicalizando A Medicina [Portuguese], Paulo A. Lotufo Dec 1998

Tropicalizando A Medicina [Portuguese], Paulo A. Lotufo

Paulo A Lotufo

No abstract provided.


Programs Of Assertive Community Treatment (Pact): A Critical Review, Tomi Gomory Dec 1998

Programs Of Assertive Community Treatment (Pact): A Critical Review, Tomi Gomory

Tomi Gomory

Advocates of Programs of Assertive Community Treatment (PACT) make numerous claims for this intensive intervention program, including reduced hospitalization, overall cost, and clinical symptomatology, and increased client satisfaction, and vocational and social functioning. However, a reanalysis of the controlled experimental research finds no empirical support for any of these claims. Instead, there is evidence that the program is both coercive and potentially harmful. The current promotion of PACT appears to be based more on professional enthusiasm for the medical model than upon any benefit to the clients.


Religiosity, Sexual Activity, And Attitudes Of Sexual Permissiveness Among Older Adolescents, Richard Fehring, K Cheever, K German, C Philpot Nov 1998

Religiosity, Sexual Activity, And Attitudes Of Sexual Permissiveness Among Older Adolescents, Richard Fehring, K Cheever, K German, C Philpot

Richard J Fehring

This study investigates religiosity, sexual activity, and sexual permissiveness among older adolescents. Eighty-two college students completed a survey that measured religiosity, sexual permissiveness, self-esteem, frequency of recent sexual encounters, and motivators for sexual activity or abstinence. Guilt, prayer, organized religious activity, and religious well-being predicted fewer sexual encounters. Orthodox beliefs, participation in organized religious activities, and highly-rated importance of faith predicted less permissive sexual attitudes. We conclude that guilt and religious activity can be good motivators for decreasing sexual encounters. We recommend that health practitioners encourage participation in religious activity among adolescents.


Projections Of Alzheimer's Disease In The United States And The Public Health Impact Of Delaying Disease Onset., Ron Brookmeyer, Sarah Gray, Claudia Kawas Nov 1998

Projections Of Alzheimer's Disease In The United States And The Public Health Impact Of Delaying Disease Onset., Ron Brookmeyer, Sarah Gray, Claudia Kawas

Ron Brookmeyer

OBJECTIVES: The goal of this study was to project the future prevalence and incidence of Alzheimer's disease in the United States and the potential impact of interventions to delay disease onset.

METHODS: The numbers of individuals in the United States with Alzheimer's disease and the numbers of newly diagnosed cases that can be expected over the next 50 years were estimated from a model that used age-specific incidence rates summarized from several epidemiological studies, US mortality rates, and US Bureau of the Census projections.

RESULTS: in 1997, the prevalence of Alzheimer's disease in the United States was 2.32 million (range: …


Power Relationships In Graduate Degree Supervision, Marcus R. Wigan Nov 1998

Power Relationships In Graduate Degree Supervision, Marcus R. Wigan

Marcus R Wigan

Supervision of graduate students has been well-studied from many different angles, but the power relationships have been the subject of only a few investigations. This thesis reports on a survey of the power relationship perceptions of Victoria University graduate students and supervising staff. A US instrument (Aguinis, Nesler, Quigley, Lee & Tedeschi, 1996) was used in a modified to obtain power relationship factors based on French and Raven’s categorisation of power relationships. These Victoria university power instrument (VUPI) scales were those of Aguinis, modified for Australian intitutions. Item analysis showed that the new scales to be well behaved and to …


A Case Study And National Database Report Of Progressive Systemic Sclerosis And Associated Conditions, David Phillips, Barbara Phillips, David M. Mannino Nov 1998

A Case Study And National Database Report Of Progressive Systemic Sclerosis And Associated Conditions, David Phillips, Barbara Phillips, David M. Mannino

David M. Mannino

We report the case of a 34-year-old white woman with a history of progressive systemic scleroderma (PSS) and diffuse alveolar hemorrhage (DAH) that may be either a rare complication of PSS or induced by D-penicillamine. The DAH progressed to hemoptysis and led to intubation for airway protection. The patient progressed to acute renal failure. Her chest x-ray revealed diffuse bilateral infiltrates. She developed pulmonary fibrosis with secondary pulmonary hypertension. She experienced a brief period of improvement of her respiratory status after steroid treatment. We also report a database of 21,442 decedents with PSS over a 15-year period from 1979 to …


Monitoring Informed Consent In An Oncology Study Posing Serious Risk To Subjects, Myrian Skrutkowski, Charles Weijer, Stan Shapiro, Abraham Fuks, Adrian Langleben, Benjamin Freedman Oct 1998

Monitoring Informed Consent In An Oncology Study Posing Serious Risk To Subjects, Myrian Skrutkowski, Charles Weijer, Stan Shapiro, Abraham Fuks, Adrian Langleben, Benjamin Freedman

Charles Weijer

No abstract provided.


Jual Obat Aborsi Cytotec Asli Di Batam Tlp 0822 2220 8881 Obat Penggugur Kandungan Kota Batam, Yolanda Putri, Obat Aborsi Asli Manjur Serta Tuntas Oct 1998

Jual Obat Aborsi Cytotec Asli Di Batam Tlp 0822 2220 8881 Obat Penggugur Kandungan Kota Batam, Yolanda Putri, Obat Aborsi Asli Manjur Serta Tuntas

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Bioethics For Clinicians: 16. Dealing With Demands For Inappropriate Treatment, Charles Weijer, Peter Singer, Bernard Dickens, Stephen Workman Oct 1998

Bioethics For Clinicians: 16. Dealing With Demands For Inappropriate Treatment, Charles Weijer, Peter Singer, Bernard Dickens, Stephen Workman

Charles Weijer

Demands by Patients or their Families for treatment thought to be inappropriate by health care providers constitute an important set of moral problems in clinical practice. A variety of approaches to such cases have been described in the literature, including medical futility, standard of care and negotiation. Medical futility fails because it confounds morally distinct cases: demand for an ineffective treatment and demand for an effective treatment that supports a controversial end (e.g., permanent unconsciousness). Medical futility is not necessary in the first case and is harmful in the second. Ineffective treatment falls outside the standard of care, and thus …


Dens Evaginatus On A Wisdom Tooth: A Diagnostic Dilemma. Case Report, Wei Cheong Ngeow, W. L. Chai Oct 1998

Dens Evaginatus On A Wisdom Tooth: A Diagnostic Dilemma. Case Report, Wei Cheong Ngeow, W. L. Chai

Wei Cheong Ngeow

Pericoronitis is the most common odontogenic problem associated with the wisdom tooth in young men and women. Patients may present with problems associated with infection, swelling and pain. However, other associated pathology such as caries, periodontal disease and referred pain from the temporomandibular joint must be investigated when treating pain from the wisdom tooth. The authors wish to present a case in which the pain from a wisdom tooth was due to a fractured dens evaginatus. The importance of this dental anomaly should not be overlooked.


A Odisseia Do Paje, Paulo A. Lotufo Oct 1998

A Odisseia Do Paje, Paulo A. Lotufo

Paulo A Lotufo

No abstract provided.


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Gaining Access Through A Calcified Pulp Chamber: A Clinical Challenge, W.C. Ngeow, Y. L. Thong Sep 1998

Gaining Access Through A Calcified Pulp Chamber: A Clinical Challenge, W.C. Ngeow, Y. L. Thong

Wei Cheong Ngeow

Dental pulp is prone to dystrophic mineralization; this mineralization can be so extensive that the entire root canal system is obliterated, As a result, root canal treatment can become a difficult if not impossible task, This article presents the endodontic management of a tooth with an obliterated pulp chamber and associated with a discharging sinus in a teenage patient, The role of a calcium hydroxide lining to induce mineralization and cause the obliteration of the pulpal space is also discussed.


Variability Of Target Volume Delineation In Cervical Esophageal Cancer, Patricia Tai, Jake Van Dyk, Edward Yu, Jerry Battista, Larry Stitt, Terry Coad Aug 1998

Variability Of Target Volume Delineation In Cervical Esophageal Cancer, Patricia Tai, Jake Van Dyk, Edward Yu, Jerry Battista, Larry Stitt, Terry Coad

Edward Yu

PURPOSE: Three-dimensional (3D) conformal radiation therapy (CRT) assumes and requires the precise delineation of the target volume. To assess the consistency of target volume delineation by radiation oncologists, who treat esophageal cancers, we have performed a transCanada survey. MATERIALS AND METHODS: One of three case presentations, including CT scan images, of different stages of cervical esophageal cancer was randomly chosen and sent by mail. Respondents were asked to fill in questionnaires regarding treatment techniques and to outline boost target volumes for the primary tumor on CT scans, using ICRU-50 definitions. RESULTS: Of 58 radiation oncologists who agreed to participate, 48 …


Canine Cone Transducin-Gamma Gene And Cone Degeneration In The Cd Dog, Gustavo D. Aguirre Aug 1998

Canine Cone Transducin-Gamma Gene And Cone Degeneration In The Cd Dog, Gustavo D. Aguirre

Gustavo D. Aguirre, VMD, PhD

Purpose: To characterize the cDNA and the organization of the gene encoding the cone-specific gamma subunit of transducin (Tgamma c) and to examine this gene as a candidate for the recessively inherited cone photoreceptor degeneration in the cd dog. 
Methods: Canine Tgamma c cDNA was cloned and sequenced. Polymerase chain reaction (PCR) was used to define the Tgamma c gene structure, northern blot analysis to examine the level of expression of Tgamma c mRNA in control and cd-affected retinas, and immunocytochemistry to determine the presence and localization of Tgamma c in normal and cd retinas.
Results: Immunocytochemical results showed Tgamma …


Identification Of A Rapd Marker Linked To Progressive Rod-Cone Degeneration In Dogs, Weikuan Gu, Gregory M. Acland, Amelia A. Langston, Elaine A. Ostrander, Gustavo D. Aguirre, Kunal Ray Aug 1998

Identification Of A Rapd Marker Linked To Progressive Rod-Cone Degeneration In Dogs, Weikuan Gu, Gregory M. Acland, Amelia A. Langston, Elaine A. Ostrander, Gustavo D. Aguirre, Kunal Ray

Gustavo D. Aguirre, VMD, PhD

Random amplified polymorphic DNA (RAPD) analysis has been used widely in plant and fungi for identification of markers linked to genetic traits and mapping, but its use is limited to identification of intra- and inter-species difference in domestic mammals. We report here identification of a RAPD-derived marker linked to progressive rod-cone degeneration (prcd), an inherited autosomal recessive retinal disease of dogs. A total of 400 standard 10-mer primers were used for amplification by use of DNA samples from normal (+/+) and affected (prcd/prcd) dogs. A single primer was identified which amplified a 1.5-kb DNA fragment only from normal dogs. PCR …


The Effects Of Sensory Processing Deficits On Occupational Performance In Children With Fragile X Syndrome, Grace T. Baranek, Yuki H. Chin, Laura Greiss Hess, Jann G. Yankee, Deborah D. Hatton, Stephen R. Hooper Aug 1998

The Effects Of Sensory Processing Deficits On Occupational Performance In Children With Fragile X Syndrome, Grace T. Baranek, Yuki H. Chin, Laura Greiss Hess, Jann G. Yankee, Deborah D. Hatton, Stephen R. Hooper

Laura Greiss Hess

No abstract available