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Effects Of The Selective Gsk3b Inhibitor, Tideglusib, On Ethanol Consumption, Anxiety-Like Behavior, Taste Preference, And Downstream Proteins, Sam Gottlieb, Douglas Bledsoe, Jessica L. Maltman, Alanna Morgan, Jennifer T. Wolstenholme, Michael F. Miles

Graduate Research Posters

Background: We have shown modulations in glycogen synthase kinase 3 beta (GSK3B) abundance or activity regulate ethanol consumption, suggesting potential as a therapeutic target for alcohol use disorder (AUD). Here we report the GSK3B inhibitor tideglusib’s actions on ethanol consumption, basal behaviors, and modulation of GSK3B targets.

Methods: C57BL/6J males and females received i.g. 200mg/kg tideglusib, except drinking-in-the-dark (males;100mg/kg i.p.). Drinking-in-the-dark (DID): Mice given 20% ethanol 4-hours, 4-days/week x 3 weeks and then i.p. tideglusib or vehicle x 4 days in a Latin Square design with ethanol consumption measured daily. Light/Dark Box: Mice gavaged with tideglusib or vehicle …

Influence Of 2,5-Dimethoxy-4-Iodoamphetamine (Doi) On Ethanol Preference And Consumption In C57bl/6 Male Mice, Alaina M. Jaster, Sam Gottlieb, Michael Miles, Javier González-Maeso

Graduate Research Posters

Substance use disorders (SUD) account for a large number of mental health diagnosis in the United States and around the world. Approximately 13.6 million adults 26 or older and 5.1 million young adults (ages 18-24) battled with a SUD in 2017. Alcohol Use Disorder (AUD) alone effects nearly 6% of the adult population within the United States. This creates a substantial burden on the individual, with alcohol being the third-leading cause of preventable death in the United States. Few treatments for AUD exist, with no new FDA-approved therapeutic treatments within the last 15 years. Additionally, the limited treatments we do …

Selective Gsk3b Deletion In Camk2a+ Forebrain Neurons Or Inhibition Via Tideglusib, Decreases Ethanol Consumption In C57bl/6j Mice, Sam Gottlieb, Andrew D. Van Der Vaart, Brennen O'Rourke, Michael F. Miles

Graduate Research Posters

Purpose: We previously identified glycogen synthase kinase-3 beta (Gsk3b) as a central member of a gene network highly regulated by acute ethanol in medial prefrontal cortex (mPFC) and associated with risk for alcohol dependence in humans. Further, we have demonstrated modulation of Gsk3b alters ethanol consumption in rodent models. GSK3B could thus represent a potential new therapeutic target for the treatment of alcohol use disorder (AUD). Here, we investigate the mechanisms of Gsk3b action in ethanol consumption and report preclinical evidence for the selective GSK3B inhibitor, tideglusib, as a therapeutic agent for AUD.

Methods: (1) Selective Cre-induced Gsk3b …

2018 Research & Innovation Day Program, Emily Chard, Mackenzie Corbett, Jack Hayward, Nathan Mcintyre, Joey Renaud, Rayne Crosetta, Amanda Kulack, Chris Meler, Lisanne Foxcroft, Angela Bourne, Nancy Klassen, Yaxin Xiang, Jiarui Liu, Kaitlyn Dresser, Ursula Goniarski, Lucy Kus, Taylor Wilson, Cassidy Gosling, Alan M. Batt, Jennifer James, Jennifer Martino, Charis Perrineau, Presley Smith, Jenalyn Cundy-Jones, Lisa Henderson, Jessica Bosazzi, Ashley Brandon, Sandra Lackenbauer, Isabelle Love, Mikaila Boon, Jessica Knoop, Emma Frigault, Laura Herbert, Morgan Benner, Shannon Webb, Amanda Manship-Knight, Ryan Campbell, Ryan Savoie, Kristen Hajpe, Kristen Cadotte, Adam Melrose, Clara Marshall, Barbara Franco Bombachini, Mauricio Machado Silveira, Jamie Tutt, Robert Haaf, John Bennett, Natalie Aguillon, Adrian (Yizhao) Zhao, Nicholas Lediet, Julliana De Bica Bauer, Natalie Mastracci, Nicholas J.D. Ireland, Ryan Michael White, Jeremy Mcivor, Matthew Gauthier, Gregory Strybosch, Jeffery Lowe, Brandon Donkersgoed, Jordan Jarvis, Mason Tybring, Rob Szabo, Ryan Kelly, Jordan Salisbury, Amneh Kalloush, Solomon Asantey, Megan Jackson, Bonnie Pierotti, Nicholas Koehler, Leap Junction, Trevor Whitehead, Allison Gray, Laura Awyers, Eli Paddle, William Pol, Rick Oskirko, Sara Bellaire, Trisha Tran, Karen Buchholz, Leah Ernst, Craig Crane, Hannah Bacro, Xiaochen Cui, Lindsey Webber, Zhong Yan, Kaitlin Dyck, Lisa Bandman, Siobhan Latimer, Lida Sobhani, Jeni Pawluch, Natalie Krzeminski, May Ali, Kristina Victoria, Kirsty Bell, Sasha Owens, Cheryl Ketola, Michael Jennings, Ontario Beekeeping Association, William Jones, Amy Turnbull, Chris Talbot, Liam Johnstone, Zachary Simao, Liam Ricci, Joanna Korvemaker, Nicole Leak, Laura Dent, Ed Van Der Maarel, Emily Mitchell, Greg Nakonecznyj, Fadwa El-Naid, Olga Tkachenko, Lorraine Franklin, Jessica Burton, Heather Tessier, Madelyn Allen, Bianca La Marra, Ashley Clarke, Helen Harrison, Anne Lamesse, Taylee Jackson, Leah Sullivan, Lorena Bonilla, Julia Gilmour, Tamara Nelson, Abbey Parkinson, Allison Menegoni, Celine Bourbonnais-Macdonald, Liz Moore, Ashley Thorne, Elizabeth Mathe, Rebecca Smith, Leah Marshall, Cayley Angell, Allan Tessier, Maria Christina Riano, Jennifer Wright, Meredeth Jones, Russell Schnurr, James Todd, Geraldo Pinto Junion, May A. Malek Ali, Mohamed Sedky, Ahmed Elsherif, Aly Magdy Ibrahim, Marc Colbeck, Sonja Maria, Georgette Eaton, Craig Campbell, Matthew Caffey, Matt Hunter, Seyed A. Goosheh, Sarah Benbow, Abe Oudshroorn, Michael Meyers

Centre for Research and Innovation Publications

A one day showcase of applied research, social innovation, scholarship projects and activities.

The Metabolism Of Alcohol: Risk And Protective Factors, Sydney E. Levan, Amy Adkins, Danielle Dick, Karen G. Chartier

Undergraduate Research Posters

Purpose: Abstract for poster submission to VCU Poster Symposium for

Undergraduate Research and Creativity

Title: The Metabolism of Alcohol: Risk and Protective Factors

Background: In 2002, it was reported by the National Institutes of Health that

60.3% of college aged students (18-22) drank alcohol in the past month of being

asked, as compared to 51.9% of those not in college. They also found that 20% of

college students met the criteria for at least one alcohol use disorder (AUDs)1.

Many genes have been linked to an increased risk for AUDs and how individuals

with various ethnic backgrounds respond to alcohol. …

Think Ethanol Is Environmentally Friendly? Think Again, Usu Jon M. Huntsman School Of Business, William F. Shughart Ii, J. Fish Smith

Jon M. Huntsman School of Business News Collection

America's prairies are disappearing at the fastest rate since the 1930s' "Dust Bowl."