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Otterbein Aegis Spring 2024, Otterbein Aegis

Aegis: The Otterbein Humanities Journal

Contents:

Essay's by Olivia Sweet, Madison Newman, Elizabeth white, Isaac Jones, Nevaeh Ellis, Abby Van Voorhis, and Gabe Whitnack.

Book Reviews by Cami Borders, Ayan Abdi, Isaac Jones, Nevaeh Ellis, Claudia Smallwood, Dane Whip, Olivia Sweet, Emily Rogers, Julia Tenbusch, Mitzi Cuaxico, Kate Hedrick, Marygrace Gorensek, Ellyse Gallagher, and Lauren Mlynarek

The Changing Tumor Microenvironment Of Non-Small Cell Lung Cancer, Mackenzie Hansen, Kim O'Neill, Qin Zhou, Yoko Derose, Magdalena Kovacsovics, Benjamin Brintz, Benjamin L. Witt, Siwen Hu-Lieskovan

Library/Life Sciences Undergraduate Poster Competition 2024

Lung cancer is the leading cause of cancer related death in the United States, and non-small cell (NSCLC) is the most common type. An increasingly prevalent treatment in the last few years for NSCLC has been immunotherapy. However, for immunotherapy to be the most effective, we need to have a better understanding of how the immune system interacts with cancer in all stages. Specifically, we need to know where the immune cells reside, how they interact with each other, and how these populations change as the disease progresses. To define the tumor microenvironment, we stained 27 whole tumor slides with …

Targeting Hsp90: A Novel Approach To Combat Synovial Sarcomas, Peyton Worley, Jared Barrott, Matt Kirkham, Drake Heithoff

Library/Life Sciences Undergraduate Poster Competition 2024

Synovial sarcomas are rare muscle cancers that have very few targeted therapies. HSP90 is a protein upregulated in this form of cancer and many others. A screening of this cancer was done in vitro, using FDA-approved drugs, showing that HSP90 could be a promising treatment option. A novel HSP90 inhibitor was applied to human and mouse synovial sarcoma cell lines and was analyzed after receiving a drug treatment for HSP90.

Jaspine B And The Sea Sponge That Fights Cancer, Jack Davis, Jared Barrott, Adriene Pavek, Farjana Afrin, Sameena Mateen, Brendon Meldrum, Rocio Rojas, Pamela Diaz, Megan Condie, Ali Aghazadeh-Habashi, Srinath Pashikanti

Library/Life Sciences Undergraduate Poster Competition 2024

Jaspine B is a natural marine product, derived from the sea sponge, Jaspis, found in some tropical climates. Jaspine B has been shown to be an effective treatment in some cancers with an upregulation of sphingomyelin synthase. This research aimed to understand the effects of Jaspine B on synovial sarcoma, and investigate its potential to be used as targeted treatment in other cancers that have an upregulation of sphingomyelin synthase

The Cold Hard Truth: Cryopreserved Tissue Is Superior To Ffpe Tissue In Molecular Analysis, Delaney Anderson, Jeffrey Okojie, Mackenzie Burr, Peyton Worley, Isaac Parker, Jack Davis, Bridger Kearns, Jared Barrott

Library/Life Sciences Undergraduate Poster Competition 2024

Personalized cancer care requires molecular characterization of neoplasms. While the research community accepts frozen tissues as the gold standard analyte for molecular assays, the source of tissue for all testing of tumor tissue in clinical cancer care comes almost universally from formalin-fixed, paraffin-embedded tissue (FFPE). Specific to genomics assays, numerous studies have shown significant discordance in genetic information obtained from FFPE samples and cryopreserved or flash frozen samples. To explain the discordance between FFPE samples and cryopreserved samples, a head-to-head comparison between FFPE and cryopreserved tissues was performed to analyze the DNA yield, DNA purity and DNA quality in terms …

Social Needs Risk And Patient Outcomes With Supportive Oncology Care, Rebecca Cammy, Lcsw, Joshua Banks, Ma

Department of Medical Oncology Posters

Objective

This study utilized social risk data in the electronic heath record collected in routine clinical practice and examined relationships with supportive oncology care contacts and patient outcomes.

Caring, 1978, V2 N4, Fall, Advocate Aurora Health

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Caring", a quarterly patient education publication. This issue has an article on the oncology unit as well as news about staffing, publications, events, and other updates.

Nutritional Support For Oncology Patients: Role For The Pcp, Annabelle S. Feist

Family Medicine Clerkship Student Projects

Adequate nutrition is a key prognostic factor in the treatment outcomes of patients with cancer diagnoses. Despite the increased morbidity and mortality of malnutrition, the importance of nutrition for oncology patients is often not well communicated and not well understood by patients. Part of this issue stems from the limited information most patient can absorb at any given doctors appointment, especially regarding their cancer. Primary care providers hold a unique position to fill this gap and have the information be heard and retained given their usual role in addressing overall health. This project compiles resources in an easily accessible and …

Addressing Burden In Caregivers Of Older Adults With Cancer, Lora Rhodes, Lcsw, Kristine Swartz, Md, Caroline Glavin, Lsw, Charlotte Zuber, Kuang-Yi Wen, Phd

Department of Medical Oncology Posters

Background

Forty-two million adults in the United States are providing unpaid care for a family member or friend over the age of 50. For approximately 2.5 million of these caregivers, cancer is the primary illness or disability of their care recipient (National Alliance for Caregiving and AARP, 2020). As baby boomers continue to age, and the number of cancer survivors continues to increase, the need for informal caregivers will expand exponentially.

While Comprehensive Geriatric Assessment (CGA) is recommended for older patients with cancer and distress screening is recommended for all cancer patients, there are currently no recommendations regarding screening for …

Where You See Smoke, There Is Probably Fire, Algimantas Simpson, Isait Alvarado, Marvin Sineath Jr.

South Atlantic Division GME Research Day 2024

No abstract provided.

Giving Experiences Back To Your Community, Elionel J. Vertus

High Impact Practices Student Showcase Fall 2023

The purpose of my project is to show how much people can be impacted and the importance of the next generation. This project shows how much that people can learn from each other and give fun impactful experiences to those who doesn't have the same benefits you or others do.

Crispr/Cas9-Mediated Genome Editing Of Y705 Residue Of Stat3 For Genetic Validation Of Small Molecule Inhibitors In Breast Cancer Cells​, Brittany Nicole 'Jesse' Ramirez, Moses Makokha Kasembeli Ph.D.

2023 Summer Experience

No abstract provided.

Tryphostin (Ag 879): A Potential Drug To Treat Glioblastoma, Nathan K. Jobalia, Indumati Ramireddy, Poonam Yadav, Raghupathy Vengoji, Surinder K. Batra, Nicole Shonka

Posters: 2023 Summer Undergraduate Research Program

No abstract provided.

Anti-Inflammatory Dietary Patterns Effect On Cancer Risk And Mortality: A Review In Cancer, Mathew Kramm Iv, Carrie Daniel-Macdougall

2023 Summer Experience

No abstract provided.

Psilocybin’S Effects On Neuritogenesis In Cancer Associated Neurons, Josiah M. Miller, Shamima Akhter, Tongxin Xie, Frederico O. Netto, Blake Myers, Sahana Lothumalla, Shajedul Islam, Adewale Adebayo, Moran Amit

2023 Summer Experience

No abstract provided.

S100a14 Protein Expression In Prostate Cancer Cell Lines, Benjamin Kinkor, Fangfang Qiao, Katelyn O'Neill, Jackie Hollinger, Raymond Bergan, Weining Chen

Posters: 2023 Summer Undergraduate Research Program

No abstract provided.

Development Of An Equitable, Interprofessional Medical Cannabis Education, Certification And Research Program In An Nci-Designated Cancer Center, Gregory Garber, Msw, Jillian Van Sciver, Mba, Denise Young, Msw, Latrisha Bentch, Ba, Bracken Babula, Md, Brooke Worster, Md

Department of Medical Oncology Posters

Background: Medical cannabis (MC), state-regulated cannabis programs accessible with a physician certification for a qualifying diagnosis, now exist in 47 states. Little attention has been paid to ensuring equitable access to such programs for the most vulnerable cancer patients.¹ Estimates of cannabis use in cancer patients range from 30-40%2 yet access to MC is highly dependent on a number of variables including: geography, cost, availability of certifying providers, lack of provider education and a confusing array of state programs coupled with ongoing federal illegality. The historic criminalization of cannabis and the disproportionate impact on People of Color creates another …

Engineering And Characterization Of Antibodies Against Cancer Biomarker Thymidine Kinase 1, Joshua Bennett, Kiara V. Whitley, Christopher J. Haynie, Kim O'Neill

Library/Life Sciences Undergraduate Poster Competition 2023

Engineered antibodies used in immunotherapies have been increasingly successful due to their ability to uniquely target cells expressing specific cancer antigens Thymidine Kinase 1 (TK 1 is a DNA salvage enzyme typically found in the cytosol However, in certain types of cancer, TK 1 is surface expressed, making it a unique cancer biomarker By identifying antibodies with a high binding affinity for TK 1 we can target cancer cells expressing TK 1 on their surface Using cell sorting and a yeast display library expressing 109 human single chain antibody fragments, we have isolated ten unique single chain antibodies scFvs that …

Surface Guided Radiation Therapy Versus Traditional Triangular Positioning, Katelyn Sausser

Medical Imaging Senior Posters

Surface-guided Radiation Therapy (SGRT) is a positioning monitoring system utilizing 3D nonionizing optical surface imaging. This system assists in patient set-up and allows for real-time monitoring of the patient’s skin surface during radiation therapy treatment. Surface-guided imaging can be used for many treatment sites such as breast, abdomen, head and neck, and extremities. SGRT is believed to have more advantages than the traditional triangular positioning including shorter set-up times, improved accuracy and reproducibility of treatment area, decreased dose, and improved patient comfort. Studies have also shown the planned dose delivery can also be monitored with SGRT and decrease dose to …

Institute Of Public Health Newsletter- Volume5, Issue1, Institute Of Public Health (Iph)

Institute of Public Health Newsletter (IPHNL)

No abstract provided.

Sgrt Eliminates Need For Patient Tattoos In Radiation Therapy, Gina Hemsley

Medical Imaging Senior Posters

Surface Guided Radiation Therapy, or SGRT, is a rapidly growing technology designed to improve radiation treatment accuracy of nearly every cancer type without the need for permanent skin tattoos. Patients were typically marked with 3 tattoos, indicating patient setup marks and isocenter marks. SGRT is an external beam radiation therapy technique which uses three-dimensional camera technology to accurately target and kill cancer cells. During patient setup and treatment, the technology uses the patient’s external surface to guarantee that the radiation dose is being consistently applied in accordance with the treatment plan, as well as tracking any patient motion throughout treatment. …

Benefits Of The Cyberknife For Prostate Treatment, Emily Baro

Medical Imaging Senior Posters

Radiation therapy is a type of cancer treatment that uses high- energy rays to kill cancer cells. There are a lot of cancers that can be treated with radiation, but a common type is prostate cancer. Prostate cancer is the most common type of cancer diagnosed in men. The types of radiation therapy used to treat prostate cancer are external beam radiation, brachytherapy, and radiopharmaceuticals. The most common machine used for radiation treatment is the linear accelerator. Most patients are treated using the linear accelerator but a select few can be treated using the cyber knife. The cyber knife is …

Cellular Glycosphingolipid Imbalance Modulates Emt In Cancer Cells, Laura E. Clark, Amanda Dickinson, Santiago Lima

Undergraduate Research Posters

Sphingolipids are key components of the plasma membrane and are regulators of complex biological processes often altered in cancer cells. In human tumors, genes of key enzymes that regulate levels of glucosylceramide and lactosylceramide are often amplified. However, it is unknown why these traits are positively selected in transformed cells. In this work, we used CRISPR-Cas9 to knockout two key enzymes amplified in tumors in HeLa and H1703 tumor-derived cell-lines. As expected, the knockout lines had dramatic accumulation of GlcCer and LacCer. However, unexpectedly, they showed significantly decreased in-vitro wound-healing capacity and an almost complete loss of in-vitro extra-cellular matrix …

Colorectal Cancer Screening In The Primary Care Setting: Community Outreach To Improve Screening Rates, Liberty J. Dupuis

Family Medicine Clerkship Student Projects

Colorectal cancer remains a leading cause of death from cancer in men and women in the U.S. and worldwide. Screening for colorectal cancer beginning at age 45 offers the opportunity for early intervention and decisive treatment for precancerous colon polyps as well as the early identification of cancer. This project aims to assess preferences around recommendations for colorectal cancer screening tests amongst a group of primary care providers as well as barriers that are commonly cited to those providers by patients who do not undergo or complete screening. The results of the provider survey were used to make recommendations for …

Labrad : Vol 47, Issue 2 - December 2022, Aga Khan University Hospital, Karachi

LABRAD

• From the Editor’s Desk
• Case Quiz
• Contrast Enhanced Spectral Mammography Clinical Usefulness of Biochemical Parameters in Prenatal Diagnosis of Down Syndrome In First and Second Trimester
• The Science of Efficiency in a Clinical Laboratory
• Updates in new WHO Blue Book
• Monkeypox vs. COVID-19
• From the Diary of a Researcher- Notes on Understanding Beta-Thalassemia and Metabolic Bone Disease
• Significance of Audit in a Clinical Laboratory
• Microsatellite Instability (MSI) Testing
• Pre-Analytical Variables Affecting Coagulation Testing
• Grading of Soft Tissue Sarcomas
• Recent Updates in 2022 WHO Classification of Thyroid Neoplasms
• MMR and MSI Testing in Malignancies
• Transforming Pedagogical Framework of Pathology through Social …

Smoking And Other Determinants Of Covid Severity Among Cancer Patients, Sameh Gomaa, Lindsay Wilde, Md, Tara Rakiewicz, Kuang-Yi Wen

Department of Medical Oncology Posters

Introduction

• Cancer patients might be more susceptible to COVID-19 infection.
• With a higher incidence of acute complications, severe disease and higher mortality rates.
• Identifying factors contributing to severe disease remains essential to avoid the risk of severe and often fatal COVID-19 exposure.
• We report on the predisposing factors for severe COVID-19 and increased hospitalization burden in cancer patients at the Sidney Kimmel Cancer Center (SKCC) in Philadelphia.

Delineating Structure-Function Relationships In Fanca Using Chaperones, Nikitha Kota, Brant R. Gracia, Natalia J. Condic, Georgios I. Karras

Summer Experience 2022

No abstract provided.

Evaluating Patient Engagement With A Digital Intervention For Adolescent And Young Adult (Aya) Stem Cell Transplant Survivors, Kellie E. Krohn, Maria Camero, Andrea K. Galvan, Martha A. Askins, Jeffery Mclaughlin, Demetrios Petropoulos, Partow Kebriaei, Susan K. Peterson

Summer Experience 2022

No abstract provided.

Generating Artificial Antigen Presenting Cells For Adoptive T-Cell Therapy, Jose Elias Martinez, Pappanaicken R. Kumar, Sachet A. Shukla

Summer Experience 2022

No abstract provided.

The Mrna/Protein Relationship Is Fluid And Changes Across Tissue And Diseased States, Jose Humberto Giraldez Chavez, Sam Payne

Library/Life Sciences Undergraduate Poster Competition 2022

• Cancer is a dysregulated cell
• Molecular typing via DNA/RNA/protein
• Is RNA a proxy for cell?