Digital Commons Network^™

Parameter Optimisation Of Coaxial Melt Electrowriting, Anne-Katrin Gruska

University of Wollongong Thesis Collection 2017+

Melt electrowriting (MEW) is an additive manufacturing technique that combines the advantages of both, solution electrospinning and fused filament fabrication by allowing the deposition of ultra-fine fibres in a controlled way without the necessity for dispersion of the material being prepared in toxic solvents. This approach is promising for the research field of tissue engineering that requires not only different types of materials but also different manufacturing techniques for scaffolds that are supposed to provide robust but flexible support, which facilitates cell growth without causing damage to the surrounding tissue.

Recent advances in MEW technology (Mar 2018) that allow the …

Development Of A Platform For The Biofabrication Of Endocrine Pancreatic Tissue Constructs Through Co-Axial Micro-Extrusion, Max Jurie Renes

University of Wollongong Thesis Collection 2017+

Type-1 Diabetes (T1D) is an auto-immune disease in which the insulin-producing β-cells in the islets of Langerhans are destroyed, affecting over 20 million patients worldwide. Islet transplantation may offer a viable treatment strategy, but transplanted islet lifespan is limited by auto- and allo-immune responses and poor engraftment upon transplantation. Biofabrication of tissue engineered constructs encapsulating islets may offer a viable strategy, as this encapsulation may allow for immune-protection of the islets and circumvent issues associated with engraftment. Here, we describe for the first time a single-step fabrication procedure for tissue constructs incorporating isolated mouse islets with supporting endothelial progenitor cells. …