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Forgetting Distractors: Inhibition Or Decay?, Laura Werner

UNLV Theses, Dissertations, Professional Papers, and Capstones

Research on forgetting irrelevant information in working memory (WM) has supported two

conflicting theories, inhibition (Oberauer & Lewndowsky, 2016) and decay (Dagry et al., 2017;

Dagry & Barrouillet, 2017). However, these conflicting results may be due to the fact that different methods were used to assess each model. In Experiment 1, we combined those methods to create a modified distractor span task that allows for a direct comparison of the models. Participants processed words that were to be remembered (targets) and others that were to be forgotten (distractors); the amount of free time after each distractor varied, with total trial …

Restructuring Of The Axon Initial Segment In Mouse Models Of Neurodevelopmental Disorders, Rachel Ali Rodriguez

UNLV Theses, Dissertations, Professional Papers, and Capstones

Neurodevelopmental disorders (NDDs) affect more than 36% of children in countries with low- and middle- incomes (Boivin, 2015; McCoy, 2016). Interestingly, these heterogeneous disorders share a high incidence of epileptic seizures, suggesting a shared pathology. Seizures result when neuronal firing activity becomes disturbed and neurons fire excessively or in unregulated patterns. A key site in the control of neuronal firing patterns is the axon initial segment (AIS), where the local density of proteins and the morphology of the AIS in part determine the firing of neurons. We hypothesized that a disruption in the morphology and/or composition of the AIS can …