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Where Do We Go From Here? : Internal Medicine In The 21st Century, Medical Professionalism And Basic Concepts In Residency Training, Mi̇ne Durusu Tanriöver, Serhat Ünal
Where Do We Go From Here? : Internal Medicine In The 21st Century, Medical Professionalism And Basic Concepts In Residency Training, Mi̇ne Durusu Tanriöver, Serhat Ünal
Turkish Journal of Medical Sciences
USU TANRIÖVER, Serhat ÜNAL Department of Internal Medicine, Faculty of Medicine, Hacettepe University, 06100 Ankara - Turkey
Common Cytochrome P4503a (Cyp3a4 And Cyp3a5) And Thiopurine S-Methyl Transferase (Tpmt) Polymorphisms In Turkish Population, Müge Aydin Sayi̇toğlu, İnci̇ Yildiz, Özden Hatirnaz, Uğur Özbek
Common Cytochrome P4503a (Cyp3a4 And Cyp3a5) And Thiopurine S-Methyl Transferase (Tpmt) Polymorphisms In Turkish Population, Müge Aydin Sayi̇toğlu, İnci̇ Yildiz, Özden Hatirnaz, Uğur Özbek
Turkish Journal of Medical Sciences
Polymorphisms in the genes encoding cytochrome p450 (CYP) and thiopurine S-methyl transferase (TPMT) enzymes catalyze the metabolic reactions of several drugs. These polymorphisms might be responsible for adverse drug reactions. Turkish population data for these genes still needs to be elucidated. We aimed to detect the allele frequencies of thiopurine S-methyl transferase (TPMT), cytochrome p4503A4*1B (CYP3A4*1B) and cytochrome p4503A4*3 (CYP3A5*3) gene variants in the Turkish population. We examined the TPMT (*1, *2, *3A, *3C), CYP3A4*1B and CYP3A5*3 variant allele frequencies in a group of healthy Turkish Caucasian blood donors by using PCR-RFLP, allele-specific PCR and direct sequencing techniques. The frequencies …
Problems Encountered In The Diagnosis Of Encapsulated Follicular Variant Of Papillary Thyroid Carcinoma And The Morphological Diagnostic Criteria, Reşi̇t Doğan Köseoğlu, Nurper Onuk Fi̇li̇z, İbrahi̇m Aladağ, Ahmet Eyi̇bi̇len, Mehmet Güven
Problems Encountered In The Diagnosis Of Encapsulated Follicular Variant Of Papillary Thyroid Carcinoma And The Morphological Diagnostic Criteria, Reşi̇t Doğan Köseoğlu, Nurper Onuk Fi̇li̇z, İbrahi̇m Aladağ, Ahmet Eyi̇bi̇len, Mehmet Güven
Turkish Journal of Medical Sciences
The encapsulated follicular variant of papillary thyroid carcinoma constitutes the most common source of consultation material in thyroid pathology. We present our five consecutive cases to illustrate this issue. The diagnosis of the encapsulated follicular variant of papillary thyroid carcinoma is considerably controversial. These tumors are encapsulated neoplasms and have the nuclear features of papillary thyroid carcinoma. Although the criteria were described for the diagnosis, a considerable subjectivity is present among the pathologists. Therefore, the categories of "well differentiated carcinoma" and "well differentiated tumor of uncertain malignant potential" were included in the diagnostic spectrum of these neoplasms. Five consecutive cases …
Cerebrovascular Risk Factors And Stroke Subtypes In Different Age Groups: A Hospital-Based Study, Göksel Somay, Pinar Topaloğlu, Hakan Somay, Özlem Araal, Güli̇stan Uşak Halaç, Murat Bulkan
Cerebrovascular Risk Factors And Stroke Subtypes In Different Age Groups: A Hospital-Based Study, Göksel Somay, Pinar Topaloğlu, Hakan Somay, Özlem Araal, Güli̇stan Uşak Halaç, Murat Bulkan
Turkish Journal of Medical Sciences
We prospectively studied the characteristics of 401 patients with first-ever-in-a lifetime stroke who have been admitted consecutively into stroke care unit. During the evaluation of distribution according to age, patients were divided into 7 age groups with 10-year intervals. It was determined that ischemic stroke was mostly seen in the age group 71-80 (32.2%) and the age group 61-70(28.2%). The major risk factor of ischemic stroke was hypertension, followed by diabetes mellitus, ischemic heart disease, smoking and hypercholesterolemia. The three most frequent etiologic categories were small-vessel disease, atherosclerotic large vessel disease and cardioembolism. The anatomical distribution of ischemic stroke were …
Identification And Seasonal Distribution Of Airborne Fungi In Urban Outdoor Air In An Eastern Black Sea Turkish Town, Murat Topbaş, İlknur Tosun, Gamze Çan, Neşe Kaklikkaya, Faruk Aydi̇n
Identification And Seasonal Distribution Of Airborne Fungi In Urban Outdoor Air In An Eastern Black Sea Turkish Town, Murat Topbaş, İlknur Tosun, Gamze Çan, Neşe Kaklikkaya, Faruk Aydi̇n
Turkish Journal of Medical Sciences
The aim of the present report was to evaluate the prevalent species of airborne fungi in the outdoor environment in the city of Trabzon, Turkey. The area is surrounded by high mountains running parallel to the Black Sea, and has a mostly rainy and temperate climate together with a most varied and widespread flora. Air samples were collected in four seasons by means of the gravitational settling method using petri dishes with SDA culture media. Those fungi colonies that formed after an incubation period of 7-10 days at 25 ºC were determined on the basis of micro and macromorphological features. …
What Are The Predictors Of Health Services Utilization By Women In A City Center Located In The Eastern Part Of Turkey ?: A Cross Sectional Study, Di̇lek Aslan, Hi̇lal Özcebe, Nazmi̇ Bi̇li̇r, Songül Vai̇zoğlu, Nükhet Subaşi
What Are The Predictors Of Health Services Utilization By Women In A City Center Located In The Eastern Part Of Turkey ?: A Cross Sectional Study, Di̇lek Aslan, Hi̇lal Özcebe, Nazmi̇ Bi̇li̇r, Songül Vai̇zoğlu, Nükhet Subaşi
Turkish Journal of Medical Sciences
The aim of this study is to evaluate factors influencing utilization of health services by women aged 15 years and older having any health symptoms within the previous 15 days in a city center located in the eastern part of Turkey. In this cross-sectional study, subjects (1,000 households) were sampled from the "city-information-system" based on household satellite photographs of the city. Nine hundred and thirty-five households out of 1,000 were included in the study (response rate: 93.5%), and 1,613 subjects were interviewed. Seven hundred and eighteen women out of 1,613 participants reported at least one health symptom (44.5%), and of …
Morbidity Pattern Among The Elderly Population In The Rural Area Of Tamil Nadu, India, Anil Jacob Purty, Joy Bazroy, Malini Kar, Kavita Vasudevan, P. Zacharia, Purushottam Panda
Morbidity Pattern Among The Elderly Population In The Rural Area Of Tamil Nadu, India, Anil Jacob Purty, Joy Bazroy, Malini Kar, Kavita Vasudevan, P. Zacharia, Purushottam Panda
Turkish Journal of Medical Sciences
Globally there are an estimated 605 million people aged 60 years and above. From the morbidity point of view, almost 50 per cent of the Indian elderly have chronic diseases and 5 percent suffer from immobility. A major component of the burden of illness for the elderly derives from prevalent chronic disease. Hence a study was undertaken to assess the present morbidity pattern of rural elderly persons. A community based cross-sectional study was undertaken in the rural service area of Pondicherry Institute of Medical Sciences (PIMS) between october 1, 2002 to October 31, 2003. All persons above the age of …
Attitudes Of Nigerian Medical Students Towards Autopsy, Victor James Ekanem, Kingsley O. Akhigbe
Attitudes Of Nigerian Medical Students Towards Autopsy, Victor James Ekanem, Kingsley O. Akhigbe
Turkish Journal of Medical Sciences
The use of autopsy in medical education has been declining although autopsy as an educational experience helps students to correlate clinical findings with basic medical sciences. Students' views in relation to its relevance in medical education are necessary in order to justify its continuous inclusion in medical school curriculum. Two hundred and forty 5th and 6th year medical students who had completed their postings in Anatomical and forensic pathology from two institutions were randomly selected for the study. The students were asked to respond anonymously to a 21 item questionnaire which dealt with their views on the importance of autopsy …
Follicular Thyroid Carcinoma In A Patient With Graves' Disease, Mehmet Özdoğan, Ahmet Gürer, Beki̇r Çakir, Si̇bel Orhun, İsmai̇l Gömceli̇, Selma Göğkuş, Raci̇ Aydin
Follicular Thyroid Carcinoma In A Patient With Graves' Disease, Mehmet Özdoğan, Ahmet Gürer, Beki̇r Çakir, Si̇bel Orhun, İsmai̇l Gömceli̇, Selma Göğkuş, Raci̇ Aydin
Turkish Journal of Medical Sciences
ZDOĞAN^1, Ahmet GÜRER^1, Bekir ÇAKIR^2, Sibel ORHUN^3, İsmail GÖMCELİ^1, Selma GÖĞKUŞ^1, Raci AYDIN^1 ^1Department of General Surgery, Atatürk Educational and Research Hospital, Ankara - Turkey ^2Department of Endocrinology, Atatürk Educational and Research Hospital, Ankara - Turkey ^3Department of Pathology, Atatürk Educational and Research Hospital, Ankara - Turkey
Malignant Meningioma Of Scalp, Mehmet Dumlu Aydin, Canan Atalay, Umran Yildirim, Mustafa Atasoy
Malignant Meningioma Of Scalp, Mehmet Dumlu Aydin, Canan Atalay, Umran Yildirim, Mustafa Atasoy
Turkish Journal of Medical Sciences
umlu AYDIN^1, Canan ATALAY^2, Umran YILDIRIM^3, Mustafa ATASOY^4 ^1Department of Neurosurgery, Faculty of Medicine, Atatürk University, Erzurum - Turkey ^2Department of Anesthesiology and Reanimation, Faculty of Medicine, Atatürk University, Erzurum - Turkey ^3Department of Pathology, Faculty of Medicine, Atatürk University, Erzurum - Turkey ^4Department of Dermatology, Faculty of Medicine, Atatürk University, Erzurum - Turkey
Hemangioma Of The Rib, Gülgün Yilmaz Ovali, Ci̇han Göktan, Serdar Tarhan, Şebnem Örgüç, Semi̇n Ayhan, Osman Saribülbül, Rahmi̇ Zeybek
Hemangioma Of The Rib, Gülgün Yilmaz Ovali, Ci̇han Göktan, Serdar Tarhan, Şebnem Örgüç, Semi̇n Ayhan, Osman Saribülbül, Rahmi̇ Zeybek
Turkish Journal of Medical Sciences
ILMAZ OVALI^1, Cihan GÖKTAN^1, Serdar TARHAN^1, Şebnem ÖRGÜÇ^1, Semin AYHAN^2, Osman SARIBÜLBÜL^3, Rahmi ZEYBEK^3 ^1Department of Radiology, Faculty of Medicine, Celal Bayar University, Manisa - Turkey ^2Department of Pathology, Faculty of Medicine, Celal Bayar University, Manisa - Turkey ^3Department of Thoracic Surgery, Faculty of Medicine, Celal Bayar University, Manisa - Turkey
Reversal Of Endotoxin-Induced Hypotension By Inhibition Of Inducible Nitric Oxide Synthase Activity Is Associated With Improved Oxidative Status In Rat Heart, Aorta And Mesenteric Artery, Bahar Tunçtan, Belma Korkmaz, Hati̇ce Yildirim, Lülüfer Tamer, Uğur Ati̇k, C. Kemal Buharalioğlu
Reversal Of Endotoxin-Induced Hypotension By Inhibition Of Inducible Nitric Oxide Synthase Activity Is Associated With Improved Oxidative Status In Rat Heart, Aorta And Mesenteric Artery, Bahar Tunçtan, Belma Korkmaz, Hati̇ce Yildirim, Lülüfer Tamer, Uğur Ati̇k, C. Kemal Buharalioğlu
Turkish Journal of Medical Sciences
Overproduction of reactive oxygen and nitrogen species leads to oxidative stress and decreased total antioxidant capacity, which is responsible for high mortality from several diseases such as endotoxic shock. Nitric oxide (NO) produced by inducible NO synthase (iNOS) during endotoxemia is the major cause of vascular hyporeactivity, hypotension and multiple organ failure. We investigated whether NO-mediated oxidative stress in rat heart, aorta and mesenteric artery is involved in the attenuation of endotoxin-induced hypotension by inhibition of iNOS. In conscious male Wistar rats, injection of endotoxin (10 mg/kg, i.p.) caused a gradual fall in mean arterial pressure (MAP) for 4 hours …
The Morphometric Measurements Of Humerus Segments, Ş. Deni̇z Akman, Pinar Karakaş, Memduha Gülhal Bozkir
The Morphometric Measurements Of Humerus Segments, Ş. Deni̇z Akman, Pinar Karakaş, Memduha Gülhal Bozkir
Turkish Journal of Medical Sciences
The aim of the present study was to determine the lengths of humerus segments in the Turkish population and compare these with the data from other countries' population for use in forensic and archeological cases. For this purpose one hundred and twenty (56 left side and 64 right side) male adult dry Caucasians' humerus bones were taken to measure the morphometric properties of humerus segments. Six segments on the articular surface of the humerus (Maximum height of the humerus (MHH), and the distances between the articular segment of the humeral head and the greater tuberosity (H1), caput humeri and collum …
The Status Of Oxidants And Antioxidants In The Neutrophils Of Patients With Recurrent Aphthous Stomatitis, Hi̇lmi̇ Cevdet Altinyazar, Ahmet Gürel, Rafet Koca, Ferah Armutçu, Murat Ünalacak
The Status Of Oxidants And Antioxidants In The Neutrophils Of Patients With Recurrent Aphthous Stomatitis, Hi̇lmi̇ Cevdet Altinyazar, Ahmet Gürel, Rafet Koca, Ferah Armutçu, Murat Ünalacak
Turkish Journal of Medical Sciences
Recurrent aphthous stomatitis (RAS) is an inflammatory condition of unknown etiology. The exact role of the leukocytes in the pathogenesis of RAS is not known. The aim of this study was to evaluate the status of the oxidative system in neutophils of RAS patients. A total of 26 patients and 22 sex and age matched healthy control subjects were analyzed by measuring intracellular oxidant/antioxidant enzymes and related parameters; myeloperoxidase (MPO), xanthine oxidase (XO), catalase (CAT), superoxide dismutase (SOD), adenosine deaminase (AD), malondialdehyde (MDA) and nitric oxide (NO). Statistically significant increases in the activities of SOD, CAT and levels of MDA, …
Determination Of Nuclear Matrix Protein 22 Levels In Cystitis, Urothelial Dysplasia And Urothelial Carcinoma, Ahmet Gödekmerdan, Seyfetti̇n Yahşi̇, Ati̇lla Semerci̇öz, Fulya İlhan, Nusret Akpolat, Hayreddi̇n Yekeler
Determination Of Nuclear Matrix Protein 22 Levels In Cystitis, Urothelial Dysplasia And Urothelial Carcinoma, Ahmet Gödekmerdan, Seyfetti̇n Yahşi̇, Ati̇lla Semerci̇öz, Fulya İlhan, Nusret Akpolat, Hayreddi̇n Yekeler
Turkish Journal of Medical Sciences
Urothelial carcinomas (UC) are the most common cancer type of the urinary system. The early diagnosis and treatment of UC are very important.The aim of this study was to evaluate the importance of the nuclear matrix protein 22 (NMP22) in early diagnosis of UC and to present its variation in cystitis and urothelial dysplasia (UD). Twenty patients with UC, 20 patients with UD and 20 patients with cystitis diagnosed by urinary cytological examination were enrolled in this study. In addition, 20 healthy people constituted the control group. Urine samples were collected from all patients and control subjects for NMP22 measurement …
Cytological And Clinical Features Of Hürthle Cell Neoplasia; Review Of The Literature Due To Three Cases, Nurper Onuk Fi̇li̇z, Reşi̇t Doğan Köseoğlu, İbrahi̇m Aladağ, Ahmet Eyi̇bi̇len, Mehmet Güven
Cytological And Clinical Features Of Hürthle Cell Neoplasia; Review Of The Literature Due To Three Cases, Nurper Onuk Fi̇li̇z, Reşi̇t Doğan Köseoğlu, İbrahi̇m Aladağ, Ahmet Eyi̇bi̇len, Mehmet Güven
Turkish Journal of Medical Sciences
NUK FİLİZ^1, Reşit Doğan KÖSEOĞLU^1, İbrahim ALADAĞ^2, Ahmet EYİBİLEN^2, Mehmet GÜVEN^2 ^1Department of Pathology, Faculty of Medicine, Gaziosmanpaşa University, Tokat - Turkey ^2 Department of Otorhinolaryngology, Faculty of Medicine, Gaziosmanpaşa University, Tokat - Turkey
Remifentanil Infusion And Paracervical Block Combination Versus Remifentanil Infusion Alone During In Vitro Fertilisation (Ivf), Ertan Öztürk, Berri̇n Günaydin, Onur Karabacak, Bi̇lge Tuncer, Mehmet Erdem, Ahmet Erdem, Bülent Tiraş, Kadi̇r Kaya
Remifentanil Infusion And Paracervical Block Combination Versus Remifentanil Infusion Alone During In Vitro Fertilisation (Ivf), Ertan Öztürk, Berri̇n Günaydin, Onur Karabacak, Bi̇lge Tuncer, Mehmet Erdem, Ahmet Erdem, Bülent Tiraş, Kadi̇r Kaya
Turkish Journal of Medical Sciences
The aim of this study is to compare two accepted techniques; intravenous (IV) remifentanil infusion versus its combination with paracervical block (PCB) in patients undergoing transvaginal ultrasound guided oocyte retrieval (TUGOR). One hundred unpremedicated patients were divided into two groups to receive either IV remifentanil (Group R) or IV remifentanil plus PCB (Group R+PCB). After monitoring cardiopulmonary parameters, remifentanil infusion of 0.25 µg kg^{-1} min-1 was started in both in groups. Additionally, when the patient felt dizzy, PCB with 10 ml 1% lidocaine was performed only in Group R+PCB followed by remifentanil infusion reduction to 0.15 µg kg^{-1} min-1. Hemodynamic …
A Comparative Microleakage Study Of Retrograd Filling Materials, Selçuk Erkut, R. Cem Tanyel, Nurullah Kekli̇koğlu, Sami̇ Yildirim, Ahmet Bülent Kati̇boğlu
A Comparative Microleakage Study Of Retrograd Filling Materials, Selçuk Erkut, R. Cem Tanyel, Nurullah Kekli̇koğlu, Sami̇ Yildirim, Ahmet Bülent Kati̇boğlu
Turkish Journal of Medical Sciences
The aim of the retrograde filling in apical resection operation is to obtain an effective and hermetic apical sealing. According to the development of technology many materials are now used in apical resection operations for retrograde fillings. An in vitro dye leakage study was performed to test the sealing ability of IRM, MTA, amalgam and zinc-phospate cement materials. Forty single rooted extracted human teeth were used in this study. After cleaning and shaping, all the roots were obturated with zinc-phospate cement and gutta-percha. Teeth were randomly divided into four groups. After root-end resections of the teeth in all groups, 3 …
In Vitro Cytotoxicity Of Glass And Carbon Fiber-Reinforced Heat-Polymerized Acrylic Resin Denture Base Material, Jüli̇de Özen, Cumhur Si̇pahi̇, Alper Çağlar, Mehmet Dalkiz
In Vitro Cytotoxicity Of Glass And Carbon Fiber-Reinforced Heat-Polymerized Acrylic Resin Denture Base Material, Jüli̇de Özen, Cumhur Si̇pahi̇, Alper Çağlar, Mehmet Dalkiz
Turkish Journal of Medical Sciences
Acrylic resin dentures may have cytotoxic effects on oral tissues. However, there is sparse data about the cytotoxic effect of fiber-reinforced acrylic resin materials. The aim of this in vitro study was to determine the cytotoxicity of a heat-polymerized acrylic resin denture base material reinforced with glass, carbon fibers and unreinforced acrylic resin denture base material. 100 acrylic resin discs were assigned to 5 experimental groups (n=20) and 1 control group. Group NOF did not receive any fiber. Roving type glass (Vetrolex) and carbon fibers (Type Tenox J) were introduced into the acrylic resin specimens of Group RGF and Group …
The First Tularemia Case In Thrace Region Of Turkey In The Last 60 Years, Şaban Gürcan, Cem Uzun, Çi̇ğdem Karagöl, Ahmet R. Karasali̇hoğlu, Meti̇n Otkun
The First Tularemia Case In Thrace Region Of Turkey In The Last 60 Years, Şaban Gürcan, Cem Uzun, Çi̇ğdem Karagöl, Ahmet R. Karasali̇hoğlu, Meti̇n Otkun
Turkish Journal of Medical Sciences
RCAN^1, Cem UZUN^2, Çiğdem KARAGÖL^1, Ahmet R. KARASALİHOĞLU^2, Metin OTKUN^1 ^1Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Trakya University, Edirne - Turkey ^2Department of Otorhinolaryngology, Faculty of Medicine, Trakya University, Edirne - Turkey
Arterial Hypertension Due To Primary Huge Hepatic Hydatid Cyst: A Case Report, Ramazan Albayrak, Rafet Yi̇ği̇tbaşi, Ayli̇n Yücel, Bumi̇n Deği̇rmenci̇, Murat Acar, Alpay Haktanir
Arterial Hypertension Due To Primary Huge Hepatic Hydatid Cyst: A Case Report, Ramazan Albayrak, Rafet Yi̇ği̇tbaşi, Ayli̇n Yücel, Bumi̇n Deği̇rmenci̇, Murat Acar, Alpay Haktanir
Turkish Journal of Medical Sciences
ALBAYRAK^1, Rafet YİĞİTBAŞ^2, Aylin YÜCEL^1, Bumin DEĞİRMENCİ^1, Murat ACAR^1, Alpay HAKTANIR^1 ^1 Department of Radiology, Kocatepe University, Faculty of Medicine, Afyon- Turkey ^2 Department of Radiology, Cerrahpaşa Faculty of Medicine, Istanbul University, İstanbul - Turkey
Two Accessory Renal Arteries With Histological Properties, Alev Kara, Zeli̇ha Kurtoğlu, İzzet Oğuz, A. Hakan Öztürk, Deni̇z Uzmansel
Two Accessory Renal Arteries With Histological Properties, Alev Kara, Zeli̇ha Kurtoğlu, İzzet Oğuz, A. Hakan Öztürk, Deni̇z Uzmansel
Turkish Journal of Medical Sciences
A^1, Zeliha KURTOĞLU^1, İzzet OĞUZ^2, A. Hakan ÖZTÜRK^1, Deniz UZMANSEL^1 ^1Department of Anatomy, Faculty of Medicine, Mersin University, 33169 Mersin - Turkey ^2Department of Histology and Embryology, Faculty of Medicine, Mersin University, 33169 Mersin - Turkey
Changes - New Horizons, M. Mahir Ozmen
Changes - New Horizons, M. Mahir Ozmen
Turkish Journal of Medical Sciences
No abstract provided.
The Effect Of Pre-Injury Supplementation With Selenium Or Vitamin E On Lipid Peroxidation And Antioxidant Enzymes In Burn Injury, Ramazan Memi̇şoğullari, Kenan Gümüşteki̇n, Şenol Dane, Fati̇h Akçay
The Effect Of Pre-Injury Supplementation With Selenium Or Vitamin E On Lipid Peroxidation And Antioxidant Enzymes In Burn Injury, Ramazan Memi̇şoğullari, Kenan Gümüşteki̇n, Şenol Dane, Fati̇h Akçay
Turkish Journal of Medical Sciences
Aim: The purpose of this experimental study was to investigate the effect of pre-injury supplementation with vitamin E or selenium on antioxidant enzyme and malondialdehyde levels, as markers of lipid peroxidation, after thermal injury to rats. Materials and Methods: The animals were divided into 3 groups: Group 1 (n = 15): controls, no supplementation; Group 2 (n = 14): received vitamin E (100 mg/kg per day) for 10 days pre-burn; Group 3 (n = 14): received selenium (4 ppm in drinking water) for 10 days pre-burn. All animals were given second-degree burns. Serum and liver tissues of the rats were …
Measurement Of Cerebral And Cerebellar Volumes In Children With Fragile X Syndrome, Ni̇met Kabakuş, Mustafa Aydin, Ahmet Kavakli, Hanefi̇ Yildirim, Haluk Akin
Measurement Of Cerebral And Cerebellar Volumes In Children With Fragile X Syndrome, Ni̇met Kabakuş, Mustafa Aydin, Ahmet Kavakli, Hanefi̇ Yildirim, Haluk Akin
Turkish Journal of Medical Sciences
Background and Aim: Fragile X syndrome (FXS) is a genetic disease associated with mental retardation, speech and memory deficits, developmental/learning disabilities, and, frequently, also with neuropsychological findings. It is known that all these abnormal brain functions could be associated with morphological anomalies of various brain regions. We investigated possible brain volume variations in children with FXS who had significant neurobehavioral symptoms and cognitive deficits. Patients and Methods: This study was performed with 8 male FXS patients who were diagnosed cytogenetically. The Leiter International Performance Scales-Revised, the Stanford-Binet Intelligence Scale, the Vineland Social Maturity Scale, and DSM IV criteria were used …
Seroprevalence Of Cytomegalovirus Antibodies In Haemodialysis Patients, Sebahatti̇n Ocak, Ni̇zami̇ Duran, Ali̇ Fuat Eski̇ocak
Seroprevalence Of Cytomegalovirus Antibodies In Haemodialysis Patients, Sebahatti̇n Ocak, Ni̇zami̇ Duran, Ali̇ Fuat Eski̇ocak
Turkish Journal of Medical Sciences
Background: Although symptoms of infection caused by cytomegalovirus (CMV) in healthy adults are generally mild, the virus is known to produce severe symptoms most often in immunocompromised patients. Patients with chronic renal failure are prone to CMV infection. CMV, as a nosocomial infection in immunocompromised patients, is a problem for clinicians. Aim: We aimed to investigate the seroprevalence of CMV infection among the haemodialysis (HD) patients in our region. Patients and Methods: Serum samples were taken from 255 patients who received treatment in 3 different HD clinics and a control group of 70 healthy persons. Enzyme-linked immunosorbent assay (ELISA) was …
Effects Of Aerobic Exercise Training On The Heart Rate-Work Rate Relationship And Estimation Of Anaerobic Threshold In Obese Females, Oğuz Özçeli̇k, Haluk Keleşti̇mur
Effects Of Aerobic Exercise Training On The Heart Rate-Work Rate Relationship And Estimation Of Anaerobic Threshold In Obese Females, Oğuz Özçeli̇k, Haluk Keleşti̇mur
Turkish Journal of Medical Sciences
Aim: The purpose of this study was to assess the effects of aerobic training on the relationship between the heart rate deflection point and anaerobic threshold (AT). Patients and Methods: Seventeen untrained, obese subjects (body mass index: 39.5 ± 1.2 kg/m^2) completed 2 incremental ramp exercise tests (15 W/min) up to the point of exhaustion using an electromagnetically-braked cycle ergometer; once at the onset and once at the end of a 4-week period. All subjects participated in a regular anaerobic exercise training programme (45 min, 3 times per-week, for 4 weeks) combined with a hypocaloric diet. Heart rate was recorded …
Investigation Of Four Different Normality Tests In Terms Of Type 1 Error Rate And Power Under Different Distributions, Derya Öztuna, Ati̇lla Hali̇l Elhan, Ersöz Tüccar
Investigation Of Four Different Normality Tests In Terms Of Type 1 Error Rate And Power Under Different Distributions, Derya Öztuna, Ati̇lla Hali̇l Elhan, Ersöz Tüccar
Turkish Journal of Medical Sciences
Background: An important aspect of the "description" of a variable is the shape of its distribution, which tells you the frequency of values from different ranges of the variable. Typically, as most of the statistical tests are based on the normality assumption, a researcher is interested in how well the distribution can be approximated by the normal distribution. Unless there are extreme violations of the normality assumptions, approved statistical tests usually provide accurate results. Although simple descriptive statistics can provide some information relevant to this issue, more precise information can be obtained by performing one of the tests of normality …
Effects Of Direct Tabletting Agents On Drug Release Kinetics And Swelling Behavior Of Hydrophilic Matrix Tablets, Evren Alğin, Müge Kiliçarslan, Ayşegül Karataş, Ni̇lüfer Yüksel, Tamer Baykara
Effects Of Direct Tabletting Agents On Drug Release Kinetics And Swelling Behavior Of Hydrophilic Matrix Tablets, Evren Alğin, Müge Kiliçarslan, Ayşegül Karataş, Ni̇lüfer Yüksel, Tamer Baykara
Turkish Journal of Medical Sciences
Aims: This work focused on the effects of direct tabletting agents (DC-agents) (Microcel PH101^®, Cellactose 80^®, Ludipress LCE^®, Pharmatose DCL11^®) and hydroxypropyl-methylcellulose (HPMC) types (Methocel^® K100LV, K15M, K100M) on release of Verapamil HCl from hydrophilic matrix tablets and swelling behaviors of these tablets. Material and Methods: Tablets were prepared by direct compression method. In vitro dissolution and swelling degree tests were performed on the tablets. The release mechanisms of drug were evaluated by using Korsmeyer-Peppas model. Results: While the increase in cellulose content of DC-agents contributed to the swelling of matrices and decreased the release rate of drug from the …
Guillain-Barré Syndrome Due To Hepatitis A, Selçuk Çomoğlu, Mustafa Cesur
Guillain-Barré Syndrome Due To Hepatitis A, Selçuk Çomoğlu, Mustafa Cesur
Turkish Journal of Medical Sciences
Guillain-Barré syndrome (GBS) is reported frequently following hepatotrophic viruses, but its occurrence due to the hepatitis A virus has been rarely reported to date. We present a case of serologically positive acute hepatitis A infection associated with GBS. There was an increased protein level in the cerebrospinal fluid and prolonged nerve conduction, with minimal axonal damage findings in electromyography.