Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (5)
- Genetics and Genomics (3)
- Medicine and Health Sciences (3)
- Cell and Developmental Biology (2)
- Amino Acids, Peptides, and Proteins (1)
-
- Biochemistry, Biophysics, and Structural Biology (1)
- Biology (1)
- Cancer Biology (1)
- Cell Biology (1)
- Chemicals and Drugs (1)
- Chemistry (1)
- Child Psychology (1)
- Clinical Psychology (1)
- Computational Biology (1)
- Computational Chemistry (1)
- Developmental Psychology (1)
- Electrical and Computer Engineering (1)
- Engineering (1)
- Epidemiology (1)
- Health Psychology (1)
- Molecular Biology (1)
- Nanotechnology (1)
- Physical Sciences and Mathematics (1)
- Psychology (1)
- Public Health (1)
- Social and Behavioral Sciences (1)
Articles 1 - 10 of 10
Full-Text Articles in Entire DC Network
Characterizing Stress Granule Regulation By Pas Kinase, Ataxin-2 And Ptc6 And Investigating The Lifespan Of Covid-19 Virus On Currency, Colleen R. Newey
Characterizing Stress Granule Regulation By Pas Kinase, Ataxin-2 And Ptc6 And Investigating The Lifespan Of Covid-19 Virus On Currency, Colleen R. Newey
Theses and Dissertations
The protein Ataxin-2 is a known positive regulator of stress granules in humans, mice and yeast (known as yeast PBP1). Due to the role that stress granules play in diseases including Amyotrophic Lateral Sclerosis (ALS) and cancer, this thesis investigates the role of Ataxin-2 and its protein binding partners in stress granule development and its effects on various metabolic phenotypes of the cell. PAS kinase is a sensory protein kinase, conserved from yeast to man, which regulates respiration and lipid biosynthesis. Our lab discovered that PAS kinase phosphorylates and activates Ataxin-2 in yeast, and that PAS kinase overexpression enhances localization …
The Genetic Associations Of Circadian Rhythm And Sleep Disorder Traits With Risk Of Monoclonal Gammopathy Of Undetermined Significance And Multiple Myeloma, Brittany Crawford
The Genetic Associations Of Circadian Rhythm And Sleep Disorder Traits With Risk Of Monoclonal Gammopathy Of Undetermined Significance And Multiple Myeloma, Brittany Crawford
Theses and Dissertations
Background: Circadian rhythm disruption and sleep have been widely studied for their roles in immunity and cancer development. Evidence for an association of circadian rhythm and sleep traits with multiple myeloma (MM) risk is inconclusive. No studies have investigated these traits in relation to monoclonal gammopathy of undetermined significance (MGUS). Given that MGUS precedes almost all MM cases, investigating sleep and circadian rhythm in relation to both MM and MGUS is necessary. The purpose of this dissertation was to explore the genetic influences of circadian rhythm and sleep traits on the risk of MGUS and MM. Methods: Data were leveraged …
Magnetic Softness Tuned Superparamagnetic Nanoparticles For Highly Efficient Cancer Theranostics, Jie Wang
Magnetic Softness Tuned Superparamagnetic Nanoparticles For Highly Efficient Cancer Theranostics, Jie Wang
Theses and Dissertations
Magnetic resonance imaging (MRI)-guided magnetic nanofluid hyperthermia (MNFH) using iron oxide based superparamagnetic nanoparticles (SPNPs) has recently attracted considerable attention as a treatment modality for cancer theranostics, because MRI-guided MNFH can allow for diagnosis, therapeutics, and prognosis simultaneously using the same administrated magnetic nanofluid agent. However, several primary limiting factors: (1) insufficient AC magnetic heating induction (specific loss power/intrinsic loss power, SLP/ILP) at the biologically safe and physically tolerable range of AC magnetic field (HAC,safe: fappl × Happl < 3.0 ~ 5.0×109 A·m-1·s-1), (2) low r2- relaxivity directly related to the low resolution of …
Atomistic Assessment Of Drug-Phospholipid Interactions Consequent To Cancer Treatment: A Study Of Anthracycline Cardiotoxicity, Yara Elsayed Ahmed
Atomistic Assessment Of Drug-Phospholipid Interactions Consequent To Cancer Treatment: A Study Of Anthracycline Cardiotoxicity, Yara Elsayed Ahmed
Theses and Dissertations
Despite being one of the most effective chemotherapeutic agents developed to date, Anthracyclines are notorious for their cardiotoxicity. Their clinical use is frequently limited both in dosage and in prescription due to the severe cardiac damage they cause. The mechanism of anthracycline-induced cardiotoxicity is not yet fully understood. However, it is hypothesized that interactions with the myocardial membrane play an important role in imparting cardiotoxicity. In this study, we use molecular dynamics simulations and density functional theory calculations to study the anthracycline drug molecules and the interactions that they have with the myocardial membrane. We construct a myocardial membrane model …
Metaproteomics Profiling Of Gut Microbiota In Pediatric Acute Lymphoblastic Leukemia Patients, Shahd Ezz El Din
Metaproteomics Profiling Of Gut Microbiota In Pediatric Acute Lymphoblastic Leukemia Patients, Shahd Ezz El Din
Theses and Dissertations
The gut microbiota is the collection of microorganisms that harbor the human gastrointestinal tract. The relation of microbiota and cancer is an emerging field as several studies have linked the gut microbiota to cancer. Such findings opened the door towards a new era of studies aiming to reveal the role of the microbiota in cancer initiation and progression. Although several metagenomic studies have provided insights into the gut microbial composition in health and diseased state, the microbial functional characteristics is still poorly understood. With current advances in mass spectrometry, comprehensive understanding of microbiota proteome became possible. In this vein, the …
Dad Talk: Father-Child Communication When A Parent Has Cancer, Elizabeth A. Reed
Dad Talk: Father-Child Communication When A Parent Has Cancer, Elizabeth A. Reed
Theses and Dissertations
Most individuals are impacted by a cancer diagnosis, in fact 54% of Americans say they or someone in their immediate family has been diagnosed with cancer at some point (CBS Interactive, 2017). While most Americans have a family member with cancer, most research has been done to understand the mother-daughter relationship during such a time. Unfortunately, there is little research regarding father-child communication during a cancer diagnosis, and father-child communication is understudied. The father-child dyad is an important relationship that impacts a child throughout their lives (Fellers & Schrodt, 2021). To further understand these relationships and how cancer may impact …
Comparing Efficiency, Empowerment, And Satisfaction Between Individual And Group Genetic Counseling For Prostate Cancer, Sarah Marie Dickman
Comparing Efficiency, Empowerment, And Satisfaction Between Individual And Group Genetic Counseling For Prostate Cancer, Sarah Marie Dickman
Theses and Dissertations
A hereditary cause for prostate cancer can be identified in 5-17% of cases, which can impact treatment and cancer screening recommendations for patients and their families. Increased demand for genetic testing has necessitated consideration of alternative genetic counseling service delivery models to meet needs. Studies have shown that group genetic counseling increases efficiency while maintaining the same patient benefits as individual genetic counseling, but research has mainly focused on patients who were assigned female at birth (AFAB). The purpose of this study was to evaluate the utility of group genetic counseling for prostate cancer by assessing participants’ satisfaction and feelings …
Evaluating Health Awareness In Cancer Genetics Amongst The Black And African American Community In South Carolina, Annika Jaliya Gadson
Evaluating Health Awareness In Cancer Genetics Amongst The Black And African American Community In South Carolina, Annika Jaliya Gadson
Theses and Dissertations
Historically minoritized individuals are underrepresented in genomic research which limits the ability to fully understand genetic variation within the population (Sirugo et al., 2019). This creates bias that questions the effectiveness of guidelines for genetic testing, predictive risk values, and medical management. Disparities in cancer genetics may be attributed to historical events that have cultivated mistrust in research and medicine, institutional bias, provider skepticism in patient reporting of medical symptoms, and limited access to genetic testing (Saulsberry et al., 2013). More exploration is needed to better understand how to increase access and awareness of cancer genetic services to Black and …
Protacs – A Novel And Rapidly Developing Field Of Targeted Protein Degradation, Hannah R. Gatley
Protacs – A Novel And Rapidly Developing Field Of Targeted Protein Degradation, Hannah R. Gatley
Theses and Dissertations
There is a continued need for new technology and strategies for tackling cancer and other diseases, and within the current century a novel therapeutic strategy has emerged in the realm of targeted protein degradation called Proteolysis-Targeting Chimeras (PROTACs). This technology specifically targets and degrades disease-causing proteins via the ubiquitin-proteasome system, and has seen an explosion of research and intrigue in both academia and industry over the past two decades. The diversity of PROTAC classes based on the E3 ligase recruiting ligand and the target protein allows for a universal molecular structure that can be customized for a specific target and …
Profiles Of Family Functioning In Pediatric Hematology-Oncology Patients: Longitudinal Associations With Child Well-Being, Sydney Sumrall
Profiles Of Family Functioning In Pediatric Hematology-Oncology Patients: Longitudinal Associations With Child Well-Being, Sydney Sumrall
Theses and Dissertations
This study aims to assess 1) patterns of family functioning and 2) longitudinal associations between family functioning patterns and well-being in a vulnerable cohort of children with chronic illness. Caregivers of hematology (16.4%) and oncology (83.6%) patients ages 7-20 (N=55; Mage = 13.3 [SD = 2.7]; 52.7% female; 45.5% non-Latinx White, 38.2% Black or African American, 12.7% Latinx, 1.8% Asian, and 1.8% multi-racial,) reported on family functioning via the Family Assessment Device. Cluster analyses identified three mutually exclusive clusters: one high adaptive group, one moderate adaptive group, and one maladaptive group. Group membership was not significantly …