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Periodontitis; Simvastatin; Pyrophosphate; GSK-3 inhibitor; Thermoresponsive Hydrogel; Pluronic F127
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Development Of Local Drug Delivery Systems For Periodontal Disease, Yosif Hassan Almoshari
Development Of Local Drug Delivery Systems For Periodontal Disease, Yosif Hassan Almoshari
Theses & Dissertations
Periodontitis is an inflammatory disease induced by complex interactions between the host immune system and pathogens that affect the integrity of teeth-supporting tissues. To prevent disease progression and thus preserve the alveolar bone structure, simultaneous anti-inflammatory and osteogenic intervention is essential. Hence, simvastatin (SIM) and a glycogen synthase kinase 3 beta inhibitor (BIO) were selected as anti-inflammatory and osteogenic agents.
First, SIM is a HMG-CoA reductase inhibitor widely prescribed for hypercholesterolemia. It has been reported to ameliorate inflammation and promote osteogenesis. Its clinical applications on these potential secondary indications, however, have been hampered by its lack of osteotropicity and poor …