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Detailing The Effects Of Cannabidiol On Exosome Release In Ewing’S Sarcoma, Bennett Hasley
Detailing The Effects Of Cannabidiol On Exosome Release In Ewing’S Sarcoma, Bennett Hasley
Theses
Ewing’s sarcoma (ES) is a highly aggressive pediatric cancer found within bone that carries a low five-year survival rate within its patients. This is due, in part, to the cancer’s high malignancy properties as well as the development of resistance to the chemotherapies used to combat this cancer. This project aims to determine if cannabidiol (CBD) has an effect on either exosome release or the protein, signal transducer and activator of transcription 3 (STAT3) within ES cells. Exosomes are vesicles that can carry proteins and other signaling molecules which are released by the cell and allow for cell-to-cell communication. Within …
A Comparative Study On Cannabidiol In Melanoma Migration And Invasion: Charlotte's Web Vs. Purified Cbd, 2020–2021, Ruby Thamert
A Comparative Study On Cannabidiol In Melanoma Migration And Invasion: Charlotte's Web Vs. Purified Cbd, 2020–2021, Ruby Thamert
Theses
Over the last decade, much attention has been focused on compounds from Cannabis sativa in treating a variety of diseases including cancer. This study examines the abilities of two different cannabidiol oils to decrease the migration and invasion of melanoma cells in vitro. Skin cancers are the most common cancers in the world. While malignant melanoma is the least common type of skin cancer, it is the deadliest. Patients diagnosed with stage IV disease have only a 15-20% five-year survival rate even with aggressive multimodal treatment, demonstrating the need for additional therapeutic options. Because melanoma is often fatal when …
Examining Dissociation And Cannabis Use As Links In The Pathway Between Childhood Maltreatment And Schizotypy, Brittany A. Blose
Examining Dissociation And Cannabis Use As Links In The Pathway Between Childhood Maltreatment And Schizotypy, Brittany A. Blose
Theses
Childhood maltreatment (CM) is a risk factor for a number of psychiatric consequences, including many different mental disorders. Recent research has focused on the connection that CM has with schizotypy and how these adverse experiences during development contribute to symptomatology. Studies have demonstrated that peritraumatic dissociation experienced during CM and trait dissociative symptoms may indirectly affect the relationship between CM and schizotypic psychopathology, helping to elucidate this complex relationship. Moreover, research has indicated cannabis use, especially its use in adolescence, as a potential moderator in the CM-schizotypy relationship. That is, cannabis use further increases the risk that maltreated individuals will …
Associations Between Cannabis Use Characteristics, Impulsivity, And Mindfulness, Sam Feck
Associations Between Cannabis Use Characteristics, Impulsivity, And Mindfulness, Sam Feck
Theses
Dual-process theories of addiction have suggested that drug use behavior is influenced by the interaction between an automatic system, which uses affective and motivational significance to appraise stimuli rapidly, and a reflective system, which includes conscious emotion regulation and decision making. The current study examined the constructs of impulsivity and mindfulness, selected to approximate the automatic and reflective systems, respectively, and their associations with cannabis use characteristics. Research suggests deficits in impulsivity and mindfulness are hallmark characteristics of substance use. However, evidence supporting this association specific to cannabis use is inconsistent. A community sample of adults (N = 289, 137 …