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The Implications Of Ferroptosis In Antibiotic Resistance, Marysol Hohl
The Implications Of Ferroptosis In Antibiotic Resistance, Marysol Hohl
Senior Honors Theses
Bacterial infections in the United States are becoming increasingly resistant to existing antibiotic treatments. Due to projected increases in resistance and the recent decrease in novel antibacterials, experts have determined that the United States is in the “post-antibiotic era.” The scientific community has failed to resolve resistance despite the continual discovery of new antibiotic compounds. In the past decade, a novel form of cell death called ferroptosis has been implicated in antibiotic treatment by employing the use of nanotechnology. This literature review will describe the problem of bacterial resistance and demonstrate how current research is pioneering a new age of …
Escherichia Coli And Antibiotic Resistance To Tetracycline Antibiotics, Taylor L. Dodgen
Escherichia Coli And Antibiotic Resistance To Tetracycline Antibiotics, Taylor L. Dodgen
Senior Honors Theses
Escherichia coli cells growing under ideal conditions are able to complete one reproduction cycle in as little as every twenty minutes. Since so many generations are able to be observed, one should theoretically be able to observe thousands of generations and determine evolution’s effects over a short period of time. In this experiment, E. coli K12 cells were cultured under ideal growth conditions but in the presence of antibiotics as a selective environmental stress in order to select for resistance. This was accomplished by serially passing colonies that were in close contact with two different, but similar antibiotics over a …
The Effects Of Triclosan Derivatives Against The Growth Of Staphylococcus Aureus, Joseph R. Grubbs Jr.
The Effects Of Triclosan Derivatives Against The Growth Of Staphylococcus Aureus, Joseph R. Grubbs Jr.
Senior Honors Theses
Triclosan is an antimicrobial commonly used in many different antiseptics and everyday products. Unfortunately, many bacteria are now resistant to triclosan due to innate resistance, mutations in the fabI gene, and/or overexpression of certain other genes (soxS, marA, and an efflux pump encoded by acrAB). Therefore, it is essential that drugs be developed to destroy bacteria now resistant to triclosan. In this experiment, four different derivatives of triclosan were tested for antibacterial capabilities under the supervision of Dr. Hubbard at Liberty University. The derivatives were synthesized by Professor McGibbon (professor of organic chemistry at LU). Solutions of 4.0 ug/mL of …