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Increased Hippocampal Probdnf Contributes To Memory Impairments In Aged Mice, Mona Buhusi, Chris Etheredge, Ann-Charlotte Granholm, Catalin V. Buhusi

Psychology Faculty Publications

Memory decline during aging or accompanying neurodegenerative diseases, represents a major health problem. Neurotrophins have long been considered relevant to the mechanisms of aging-associated cognitive decline and neurodegeneration. Mature Brain-Derived Neurotrophic Factor (BDNF) and its precursor (proBDNF) can both be secreted in response to neuronal activity and exert opposing effects on neuronal physiology and plasticity. In this study, biochemical analyses revealed that increased levels of proBDNF are present in the aged mouse hippocampus relative to young and that the level of hippocampal proBDNF inversely correlates with the ability to perform in a spatial memory task, the water radial arm maze …

Bisphenol-A Exposure During Adolescence Leads To Enduring Alterations In Cognition And Dendritic Spine Density In Adult Male And Female Rats, Rachel E. Bowman, Victoria N. Luine, Samantha Diaz Weinstein, Hameda Khandaker, Sarah Dewolf, Maya Frankfurt

Psychology Faculty Publications

We have previously demonstrated that adolescent exposure of rats to bisphenol-A (BPA), an environmental endocrine disrupter, increases anxiety, impairs spatial memory, and decreases dendritic spine density in the CA1 region of the hippocampus (CA1) and medial prefrontal cortex (mPFC) when measured in adolescence in both sexes. The present study examined whether the behavioral and morphological alterations following BPA exposure during adolescent development are maintained into adulthood. Male and female, adolescent rats received BPA, 40 μg/kg/bodyweight, or control treatments for one week. In adulthood, subjects were tested for anxiety and locomotor activity, spatial memory, non-spatial visual memory, and sucrose preference. Additionally, …

Hippocampal Volume And Auditory Attention On A Verbal Memory Task With Adult Survivors Of Pediatric Brain Tumor, Reema Jayakar, Tricia Z. King, Robin Morris, Sabrina Na

Psychology Faculty Publications

Objective: We examined the nature of verbal memory deficits and the possible hippocampal underpinnings in long-term adult survivors of childhood brain tumor. Method: 35 survivors (M=24.10±4.93 years at testing; 54% female), on average 15 years post-diagnosis, and 59 typically developing adults (M=22.40±4.35 years, 54% female) participated. Automated FMRIB Software Library (FSL) tools were used to measure hippocampal, putamen, and whole brain volumes. The California Verbal Learning Test – Second Edition (CVLT-II) was used to assess verbal memory. Results: Hippocampal (F(1,91)=4.06, η_p²=.04), putamen (F(1,91)=11.18, η_p²=.11), and whole brain (F(1,92)=18.51, …

Sources Of Interference In Recognition Testing, Jeffrey Annis, Kenneth J. Malmberg, Amy Criss, Richard M. Shiffrin

Psychology Faculty Publications

Recognition memory accuracy is harmed by prior testing (a.k.a., output interference [OI]; Tulving & Arbuckle, 1966). In several experiments, we interpolated various tasks between recognition test trials. The stimuli and the tasks were more similar (lexical decision [LD] of words and nonwords) or less similar (gender identification of male and female faces) to the stimuli and task used in recognition testing. Not only did the similarity between the interpolated and recognition tasks not affect recognition accuracy but performance of the interpolated task caused no interference in subsequent recognition testing. Only the addition of recognition trials caused OI. When we presented …

Self-Defining Memories, Scripts, And The Life Story: Narrative Identity In Personality And Psychotherapy, Jefferson A. Singer, Pavel Blagov, Meredith Berry, Kathryn M. Oost

Psychology Faculty Publications

An integrative model of narrative identity builds on a dual memory system that draws on episodic memory and a long-term self to generate autobiographical memories. Autobiographical memories related to critical goals in a lifetime period lead to life-story memories, which in turn become self-defining memories when linked to an individual's enduring concerns. Self-defining memories that share repetitive emotion-outcome sequences yield narrative scripts, abstracted templates that filter cognitive-affective processing. The life story is the individual's overarching narrative that provides unity and purpose over the life course. Healthy narrative identity combines memory specificity with adaptive meaning-making to achieve insight and well-being, as …

The Impact Of Sleep Quality On Cognitive Functioning In Parkinson's Disease, Karina Stavitsky, Sandra Neargarder, Yelena Bogdanova, Patrick Mcnamara, Alice Cronin-Golomb

Psychology Faculty Publications

In healthy individuals and those with insomnia, poor sleep quality is associated with decrements in performance on tests of cognition, especially executive function. Sleep disturbances and cognitive deficits are both prevalent in Parkinson's disease (PD). Sleep problems occur in over 75% of patients, with sleep fragmentation and decreased sleep efficiency being the most common sleep complaints, but their relation to cognition is unknown. We examined the association between sleep quality and cognition in PD. In 35 non-demented individuals with PD and 18 normal control adults (NC), sleep was measured using 24-hr wrist actigraphy over 7 days. Cognitive domains tested included …

Memory Aging: Deficits, Beliefs, And Interventions, Jane M. Berry, Erin Hastings, Robin West, Courtney Lee, John C. Cavanaugh

Psychology Faculty Publications

Of all mental faculties, memory is unique. It defines who we are and places our lives on a narrative continuum from birth to death. It helps to structure our days, it guides our daily tasks and goals, and it provides pleasurable interludes as we anticipate the future and recall the past. As a core, defining feature of the self (Birren & Schroots, 2006), memory takes on heightened meaning as we age. In the face of other losses that accumulate with age, memory can serve to preserve our sense of self and place in time. In normal aging, memory loss is …

Information-Processing Approaches To Understanding Anxiety Disorders, Richard J. Mcnally, Hannah E. Reese

Psychology Faculty Publications

Experimental psychopathologists have used cognitive psychology paradigms to elucidate information-processing biases in the anxiety disorders. A vast literature now suggests that patients with anxiety disorders are characterized by an attentional bias for threatening information and a bias toward threatening interpretations of ambiguous information. A memory bias favoring recall of threatening information occurs in panic disorder, but rarely in other anxiety disorders. New treatments involving the experimental modification of cognitive biases are promising.

Cognitive Implications Of Facilitating Echoic Persistence, Carryl L. Baldwin

Psychology Faculty Publications

Seventeen participants performed a tone-pattern-matching task at different presentation levels while concurrently engaged in a simulated-driving task. Presentation levels of 60, 65, and 70 dBC (SPL) were combined factorially with tone-matching delays of 2, 3, and 4 sec. Intensity had no effect on performance in single-task conditions and short-delay conditions. However, when the participants were engaged concurrently in the driving task, a significant interaction between presentation level and delay was observed. In the longest delay condition, the participants performed the tone-patten-matching task more efficiently (more quickly and without additional errors) as presentation intensity increased. These findings demonstrate the interaction between …

Enhancement Of Cognitive And Electrophysiological Measures Of Hippocampal Functioning In Rats By A Low, But Not High, Dose Of Dehydroepiandrosterone Sulfate (Dheas), David M. Diamond

Psychology Faculty Publications

Dehydroepiandrosterone sulfate (DHEAS) is a steroid hornone that is synthesized, de novo, in the brain. Endogenous DHEAS levels correlate with the quality of mental and physical health, where the highest levels of DHEAS occur in healthy young adults and reduced levels of DHEAS are found with advanced age, disease, or extreme stress. DHEAS supplementation, therefore, may serve as a therapeutic agent against a broad range of maladies. This paper summarizes laboratory findings on dose-response relationships between DHEAS and cognitive and electrophysiological measures of hippocampal functioning. It was found that a low, but not a high, dose of DHEAS enhanced hippocampal …

Describing Individual Incidents Of Sexual Abuse: A Review Of Research On The Effects Of Multiple Sources Of Information On Children’S Reports, Kim P. Roberts, Martine B. Powell

Psychology Faculty Publications

Objective. For successful prosecution of child sexual abuse, children are often required to provide reports about individual, alleged incidents. Although verbally or mentally rehearsing memory of an incident can strengthen memories, children’s report of individual incidents can also be contaminated when they experience other events related to the individual incidents (e.g., informal interviews, dreams of the incident) and/or when they have similar, repeated experiences of an incident as in cases of multiple abuse.

Method. Research is reviewed on the positive and negative effects of these related experiences on the length, accuracy, and structure of children’s reports of a particular incident. …

Mental And Behavioral Disturbances In Dementia: Findings From The Cache County Study On Memory In Aging, Constantine G. Lyketsos, Martin Steinberg, Joann T. Tschanz, Maria C. Norton, David C. Steffens, John C. S. Breitner

Psychology Faculty Publications

OBJECTIVE: The authors report findings from a study of 5,092 community residents who constituted 90% of the elderly resident population of Cache County, Utah. METHOD: The 5,092 participants, who were 65 years old or older, were screened for dementia. Based on the results of this screen, 1,002 participants (329 with dementia and 673 without dementia) underwent comprehensive neuropsychiatric examinations and were rated on the Neuropsychiatric Inventory, a widely used method for ascertainment and classification of dementia-associated mental and behavioral disturbances. RESULTS: Of the 329 participants with dementia, 214 (65%) had Alzheimer’s disease, 62 (19%) had vascular dementia, and 53 (16%) …

Memory Self-Efficacy In Its Social Cognitive Context, Jane M. Berry

Psychology Faculty Publications

This chapter takes a primarily cognitive construct - memory self-efficacy (MSE) - and returns it to its roots - social cognition (Bandura, 1986). This is a natural and obvious move. MSE has evolved since the mid-1980s (Berry, West, & Powlishta, 1986; Hertzog, Dixon, Schulenberg, & Hultsch, 1987) to its present identity and status in the cognitive aging and adult developmental research literature. If it is to avoid becoming a hypothesis in search of data (Light, 1991) or worse, an epiphenomenon to more robust explanations of cognitive aging (e.g., speed) (Salthouse, 1993), its potential and limits must be scrutinized and subjected …

Age Declines In Memory Self-Efficacy: General Or Limited To Particular Tasks And Measure?, Robin Lea West, Jane M. Berry

Psychology Faculty Publications

The potential for lifelong learning has been demonstrated clearly in research on problem solving, prose recall, and other measures of mental skill (Reese & Puckett, 1993; Sinnott, 1989). However, there are factors that may serve as barriers to lifelong learning for older adults (see Arenberg, chapter 23 in this volume). Among others, these factors include age changes in attentional or memory capacity (e.g., Salthouse, 1991), declines in memory self-confidence or change in memory beliefs (e.g., Berry, West & Dennehy, 1989), and reduced opportunities for education and training (e.g., Rebok & Offermann, 1983). This chapter focuses on self-report or subjective beliefs …

Memory And Age Differences In Spatial Manipulation Ability, Timothy A. Salthouse, Deborah Mitchell, Roni Reiter-Palmon

Psychology Faculty Publications

Young and old adults were asked, in 3 experiments, to make decisions about the identity of line segment patterns after either adding or subtracting line segments from the original pattern. On some of the trials, the line segments from the initial display were presented again in the second display to minimize the necessity of remembering early information during the processing of later information. Although this manipulation presumably reduced the importance of memory in the tasks, it had little effect on the magnitude of the age differences in any of the experiments. Because the 2 groups were equivalent in accuracy of …

Memory Observed: Remembering In Natural Contexts: By U. Neisser (Book Review), Steven S. Braddon

Psychology Faculty Publications

Book review by Steven S. Braddon.

Neisser, Ulric, selector. Memory Observed: Remembering in Natural Contexts. San Francisco: W.H. Freeman, 1982. ISBN 9780716713715; 9780716713722 (pbk.)