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Reversal Of Parkinsonian Symptoms In Primates By Antagonism Of Excitatory Amino Acid Transmission: Potential Mechanisms Of Action., I. J. Mitchell, C. B. Carroll
Reversal Of Parkinsonian Symptoms In Primates By Antagonism Of Excitatory Amino Acid Transmission: Potential Mechanisms Of Action., I. J. Mitchell, C. B. Carroll
Peninsula Medical School
Parkinsonism is characterised by overactive glutamatergic transmission in the cortico-striatal and subthalamo-medial pallidal pathways. Local blockade of glutamatergic transmission in these pathways can alleviate parkinsonian symptoms. The effectiveness of the treatment, however, is often limited by the simultaneous appearance of unwanted side-effects. These side-effects, including ataxia and dissociative anaesthesia, are particularly problematic when N-methyl-D-aspartate (NMDA) antagonists are used. In an attempt to overcome these problems we have attempted to manipulate excitatory amino acid (EAA)-mediated neurotransmission indirectly by targeting the NMDA receptor associated modulatory sites. We review evidence which demonstrates that antagonists for both the NMDA associated glycine and polyamine sites …
Reversal Of Parkinsonian Symptoms In Primates By Antagonism Of Excitatory Amino Acid Transmission: Potential Mechanisms Of Action., I. J. Mitchell, C. B. Carroll
Reversal Of Parkinsonian Symptoms In Primates By Antagonism Of Excitatory Amino Acid Transmission: Potential Mechanisms Of Action., I. J. Mitchell, C. B. Carroll
Peninsula Medical School
Parkinsonism is characterised by overactive glutamatergic transmission in the cortico-striatal and subthalamo-medial pallidal pathways. Local blockade of glutamatergic transmission in these pathways can alleviate parkinsonian symptoms. The effectiveness of the treatment, however, is often limited by the simultaneous appearance of unwanted side-effects. These side-effects, including ataxia and dissociative anaesthesia, are particularly problematic when N-methyl-D-aspartate (NMDA) antagonists are used. In an attempt to overcome these problems we have attempted to manipulate excitatory amino acid (EAA)-mediated neurotransmission indirectly by targeting the NMDA receptor associated modulatory sites. We review evidence which demonstrates that antagonists for both the NMDA associated glycine and polyamine sites …