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Increased Ca2+ Signaling Through Cav1.2 Promotes Bone Formation And Prevents Estrogen Deficiency-Induced Bone Loss, Chike Cao, Yinshi Ren, Adam S. Barnett, Anthony J. Mirando, Douglas Rouse, Se Hwan Mun, Kyung-Hyun Park-Min, Amy L. Mcnulty, Farshid Guilak, Courtney M. Karner, Matthew J. Hilton, Geoffrey S. Pitt
Increased Ca2+ Signaling Through Cav1.2 Promotes Bone Formation And Prevents Estrogen Deficiency-Induced Bone Loss, Chike Cao, Yinshi Ren, Adam S. Barnett, Anthony J. Mirando, Douglas Rouse, Se Hwan Mun, Kyung-Hyun Park-Min, Amy L. Mcnulty, Farshid Guilak, Courtney M. Karner, Matthew J. Hilton, Geoffrey S. Pitt
Open Access Publications
While the prevalence of osteoporosis is growing rapidly with population aging, therapeutic options remain limited. Here, we identify potentially novel roles for CaV1.2 L-type voltage-gated Ca2+ channels in osteogenesis and exploit a transgenic gain-of-function mutant CaV1.2 to stem bone loss in ovariectomized female mice. We show that endogenous CaV1.2 is expressed in developing bone within proliferating chondrocytes and osteoblasts. Using primary BM stromal cell (BMSC) cultures, we found that Ca2+ influx through CaV1.2 activates osteogenic transcriptional programs and promotes mineralization. We used Prx1-, Col2a1-, or Col1a1-Cre drivers to express an inactivation-deficient CaV1.2 mutant in chondrogenic and/or osteogenic precursors in vivo …
Lrrk2 But Not Atg16l1 Is Associated With Paneth Cell Defect In Japanese Crohn's Disease Patients, Ta-Chiang Liu, Takeo Naito, Zhenqiu Liu, Kelli L Vandussen, Talin Haritunians, Dalin Li, Katsuya Endo, Yosuke Kawai, Masao Nagasaki, Yoshitaka Kinouchi, Dermot P. B. Mcgovern, Tooru Shimosegawa, Yoichi Kakuta, Thaddeus S Stappenbeck
Lrrk2 But Not Atg16l1 Is Associated With Paneth Cell Defect In Japanese Crohn's Disease Patients, Ta-Chiang Liu, Takeo Naito, Zhenqiu Liu, Kelli L Vandussen, Talin Haritunians, Dalin Li, Katsuya Endo, Yosuke Kawai, Masao Nagasaki, Yoshitaka Kinouchi, Dermot P. B. Mcgovern, Tooru Shimosegawa, Yoichi Kakuta, Thaddeus S Stappenbeck
Open Access Publications
No abstract provided.
Mapk Signaling Promotes Axonal Degeneration By Speeding The Turnover Of The Axonal Maintenance Factor Nmnat2, Lauren J. Walker, Daniel W. Summers, Yo Sasaki, Ej Brace, Jeffrey Milbrandt, Aaron Diantonio
Mapk Signaling Promotes Axonal Degeneration By Speeding The Turnover Of The Axonal Maintenance Factor Nmnat2, Lauren J. Walker, Daniel W. Summers, Yo Sasaki, Ej Brace, Jeffrey Milbrandt, Aaron Diantonio
Open Access Publications
Injury-induced (Wallerian) axonal degeneration is regulated via the opposing actions of pro-degenerative factors such as SARM1 and a MAPK signal and pro-survival factors, the most important of which is the NAD