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Adam17 Substrate Release In Proximal Tubule Drives Kidney Fibrosis, Eirini Kefaloyianni, Muthu Lakshmi Muthu, Jakob Kaeppler, Xiaoming Sun, Venkata Sabbisetti, Athena Chalaris, Stefan Rose-John, Eitan Wong, Irit Sagi, Sushrut S. Waikar, Helmut Rennke, Benjamin D. Humphreys, Joseph V. Bonventre, Andreas Herrlich
Adam17 Substrate Release In Proximal Tubule Drives Kidney Fibrosis, Eirini Kefaloyianni, Muthu Lakshmi Muthu, Jakob Kaeppler, Xiaoming Sun, Venkata Sabbisetti, Athena Chalaris, Stefan Rose-John, Eitan Wong, Irit Sagi, Sushrut S. Waikar, Helmut Rennke, Benjamin D. Humphreys, Joseph V. Bonventre, Andreas Herrlich
Open Access Publications
Kidney fibrosis following kidney injury is an unresolved health problem and causes significant morbidity and mortality worldwide. In a study into its molecular mechanism, we identified essential causative features. Acute or chronic kidney injury causes sustained elevation of a disintegrin and metalloprotease 17 (ADAM17); of its cleavage-activated proligand substrates, in particular of pro-TNFα and the EGFR ligand amphiregulin (pro-AREG); and of the substrates' receptors. As a consequence, EGFR is persistently activated and triggers the synthesis and release of proinflammatory and profibrotic factors, resulting in macrophage/neutrophil ingress and fibrosis. ADAM17 hypomorphic mice, specific ADAM17 inhibitor-treated WT mice, or mice with inducible …
Radiographic Comparison Between Cervical Spine Lateral And Whole-Spine Lateral Standing Radiographs, Moon Soo Park, Seong-Hwan Moon, Tae-Hwan Kim, Jae Keun Oh, Hwa Jun Kang, K. Daniel Riew
Radiographic Comparison Between Cervical Spine Lateral And Whole-Spine Lateral Standing Radiographs, Moon Soo Park, Seong-Hwan Moon, Tae-Hwan Kim, Jae Keun Oh, Hwa Jun Kang, K. Daniel Riew
Open Access Publications
No abstract provided.
Natriuretic Peptide Receptor-C Is Up-Regulated In The Intima Of Advanced Carotid Artery Atherosclerosis, Mohamed A. Zayed, Scott D. Harring, Dana R. Abendschein, Chandu Vemuri, Dongsi Lu, Lisa Detering, Yongjian Liu, Pamela K. Woodard
Natriuretic Peptide Receptor-C Is Up-Regulated In The Intima Of Advanced Carotid Artery Atherosclerosis, Mohamed A. Zayed, Scott D. Harring, Dana R. Abendschein, Chandu Vemuri, Dongsi Lu, Lisa Detering, Yongjian Liu, Pamela K. Woodard
Open Access Publications
No abstract provided.
Treatment With Tumor-Treating Fields Therapy And Pulse Dose Bevacizumab In Patients With Bevacizumab-Refractory Recurrent Glioblastoma: A Case Series., George Ansstas, David D. Tran
Treatment With Tumor-Treating Fields Therapy And Pulse Dose Bevacizumab In Patients With Bevacizumab-Refractory Recurrent Glioblastoma: A Case Series., George Ansstas, David D. Tran
Open Access Publications
No abstract provided.
Improved Cardiovascular Disease Outcomes In Older Adults, Daniel E. Forman, Karen Alexander, Ralph G. Brindis, Anne B. Curtis, Matthew Maurer, Michael W. Rich, Laurence Sperling, Nanette K. Wenger
Improved Cardiovascular Disease Outcomes In Older Adults, Daniel E. Forman, Karen Alexander, Ralph G. Brindis, Anne B. Curtis, Matthew Maurer, Michael W. Rich, Laurence Sperling, Nanette K. Wenger
Open Access Publications
No abstract provided.
Socio-Demographic Differences In Toxic Release Inventory Siting And Emissions In Metro Atlanta, Ryan Johnson, Kim Ramsey-White, Christina H. Fuller
Socio-Demographic Differences In Toxic Release Inventory Siting And Emissions In Metro Atlanta, Ryan Johnson, Kim Ramsey-White, Christina H. Fuller
Open Access Publications
No abstract provided.
Two-Stage Association Study To Identify The Genetic Susceptibility Of A Novel Common Variant Of Rs2075290 In Zpr1 To Type 2 Diabetes, Fanglin Guan, Yu Niu, Tianxiao Zhang, Songfang Liu, Lei Ma, Ting Qi, Jia Feng, Hong Zuo, Guohong Li, Xufeng Liu, Shujin Wang
Two-Stage Association Study To Identify The Genetic Susceptibility Of A Novel Common Variant Of Rs2075290 In Zpr1 To Type 2 Diabetes, Fanglin Guan, Yu Niu, Tianxiao Zhang, Songfang Liu, Lei Ma, Ting Qi, Jia Feng, Hong Zuo, Guohong Li, Xufeng Liu, Shujin Wang
Open Access Publications
No abstract provided.
The Influence Of Temperament And Character Profiles On Specialty Choice And Well-Being In Medical Residents, Martin Sievert, Igor Zwir, Kevin M. Cloninger, Nigel Lester, Sandor Rozsa, C. Robert Cloninger
The Influence Of Temperament And Character Profiles On Specialty Choice And Well-Being In Medical Residents, Martin Sievert, Igor Zwir, Kevin M. Cloninger, Nigel Lester, Sandor Rozsa, C. Robert Cloninger
Open Access Publications
No abstract provided.
Hormonal Responses To Cholinergic Input Are Different In Humans With And Without Type 2 Diabetes Mellitus, Sara Chowdhury, Songyan Wang, Jundit Dunai, Rachel Kilpatrick, Lauren Z. Oestricker, Michael J. Wallendorf, Bruce W. Patterson, Dominic N. Reeds, Burton M. Wice
Hormonal Responses To Cholinergic Input Are Different In Humans With And Without Type 2 Diabetes Mellitus, Sara Chowdhury, Songyan Wang, Jundit Dunai, Rachel Kilpatrick, Lauren Z. Oestricker, Michael J. Wallendorf, Bruce W. Patterson, Dominic N. Reeds, Burton M. Wice
Open Access Publications
No abstract provided.
Prognostic Microrna Signatures Derived From The Cancer Genome Atlas For Head And Neck Squamous Cell Carcinomas, Nathan Wong, Shariq S. Khwaja, Callie M. Baker, Hiram A. Gay, Wade L. Thorstad, Mackenzie D. Daly, James S. Lewis Jr., Xiaowei Wang
Prognostic Microrna Signatures Derived From The Cancer Genome Atlas For Head And Neck Squamous Cell Carcinomas, Nathan Wong, Shariq S. Khwaja, Callie M. Baker, Hiram A. Gay, Wade L. Thorstad, Mackenzie D. Daly, James S. Lewis Jr., Xiaowei Wang
Open Access Publications
No abstract provided.
A New Glucocerebrosidase Chaperone Reduces Α-Synuclein And Glycolipid Levels In Ipsc-Derived Dopaminergic Neurons From Patients With Gaucher Disease And Parkinsonism, Hideji Fujiwara, Rohini Sidhu, Daniel S. Ory, Et Al
A New Glucocerebrosidase Chaperone Reduces Α-Synuclein And Glycolipid Levels In Ipsc-Derived Dopaminergic Neurons From Patients With Gaucher Disease And Parkinsonism, Hideji Fujiwara, Rohini Sidhu, Daniel S. Ory, Et Al
Open Access Publications
No abstract provided.
Association Between Neurological Soft Signs, Temperament And Character In Patients With Schizophrenia And Non-Psychotic Relatives, Liliana Galindo, Francisco Pastoriza, Daniel Berge, Anna Mane, Marisol Picado, Antonio Bulbena, Patricia Robledo, Victor Perez, Oscar Vilarroya, Claude Robert Cloninger
Association Between Neurological Soft Signs, Temperament And Character In Patients With Schizophrenia And Non-Psychotic Relatives, Liliana Galindo, Francisco Pastoriza, Daniel Berge, Anna Mane, Marisol Picado, Antonio Bulbena, Patricia Robledo, Victor Perez, Oscar Vilarroya, Claude Robert Cloninger
Open Access Publications
No abstract provided.
Behavioral Weight Loss Treatment For Youth Treated With Antipsychotic Medications, Ginger E. Nicol, Rachel P. Kolko, Monica Mills, Thrudur Gunnarsdottir, Michael D. Yingling, Julia A. Schweiger, Eric J. Lenze, John W. Newcomer, Denise Wilfley
Behavioral Weight Loss Treatment For Youth Treated With Antipsychotic Medications, Ginger E. Nicol, Rachel P. Kolko, Monica Mills, Thrudur Gunnarsdottir, Michael D. Yingling, Julia A. Schweiger, Eric J. Lenze, John W. Newcomer, Denise Wilfley
Open Access Publications
No abstract provided.
Esophageal Squamous Cell Cancer In A Highly Endemic Region, Akwi W. Asombang, Violet Kayamba, Mpala M. Lisulo, Kathryn Trinkaus, Victor Mudenda, Edford Sinkala, Stayner Mwanamakondo, Themba Banda, Rose Soko, Paul Kelly
Esophageal Squamous Cell Cancer In A Highly Endemic Region, Akwi W. Asombang, Violet Kayamba, Mpala M. Lisulo, Kathryn Trinkaus, Victor Mudenda, Edford Sinkala, Stayner Mwanamakondo, Themba Banda, Rose Soko, Paul Kelly
Open Access Publications
No abstract provided.
Evolutionary Signals Of Selection On Cognition From The Great Tit Genome And Methylome, Wesley C. Warren, Patrick Minx, Et Al
Evolutionary Signals Of Selection On Cognition From The Great Tit Genome And Methylome, Wesley C. Warren, Patrick Minx, Et Al
Open Access Publications
No abstract provided.
Cerebrovascular Disease And Chronic Obstructive Pulmonary Disease Increase Risk Of Complications With Robotic Partial Nephrectomy, Tyler M. Bauman, Aaron M. Potretzke, Joel M. Vetter, Sam B. Bhayani, Robert Sherburne Figenshau
Cerebrovascular Disease And Chronic Obstructive Pulmonary Disease Increase Risk Of Complications With Robotic Partial Nephrectomy, Tyler M. Bauman, Aaron M. Potretzke, Joel M. Vetter, Sam B. Bhayani, Robert Sherburne Figenshau
Open Access Publications
No abstract provided.
Clinical And Genetic Features Of Cervical Dystonia In A Large Multicenter Cohort, Joel S. Perlmutter, Laura J. Wright, Et Al
Clinical And Genetic Features Of Cervical Dystonia In A Large Multicenter Cohort, Joel S. Perlmutter, Laura J. Wright, Et Al
Open Access Publications
No abstract provided.
Distinct Effects Of Obesity And Puberty On Risk And Age At Onset Of Pediatric Ms, Soe Mar, Et Al
Distinct Effects Of Obesity And Puberty On Risk And Age At Onset Of Pediatric Ms, Soe Mar, Et Al
Open Access Publications
No abstract provided.
Pilot Clinical Observations Between Food And Drug Seeking Derived From Fifty Cases Attending An Eating Disorder Clinic, Harriet Beitscher-Campbell, Kenneth Blum, Marcelo Febo, Margaret A. Madigan, John Giordano, Rajendra D. Badgaiyan, Eric R. Braverman, Kristina Dushaj, Mona Li, Mark S. Gold
Pilot Clinical Observations Between Food And Drug Seeking Derived From Fifty Cases Attending An Eating Disorder Clinic, Harriet Beitscher-Campbell, Kenneth Blum, Marcelo Febo, Margaret A. Madigan, John Giordano, Rajendra D. Badgaiyan, Eric R. Braverman, Kristina Dushaj, Mona Li, Mark S. Gold
Open Access Publications
No abstract provided.
Psychometric Properties Of The Greek Tci-R And Its Clinical Correlates: Schizotypy And The Self-Regulation Of Affective And Cognitive Functioning, Stella G. Giakoumaki, Leda Karagiannopoulou, Sandor Rozsa, Chrysoula Zouraraki, Penny Karamaouna, C. Robert Cloninger
Psychometric Properties Of The Greek Tci-R And Its Clinical Correlates: Schizotypy And The Self-Regulation Of Affective And Cognitive Functioning, Stella G. Giakoumaki, Leda Karagiannopoulou, Sandor Rozsa, Chrysoula Zouraraki, Penny Karamaouna, C. Robert Cloninger
Open Access Publications
No abstract provided.
Genetic Association Of Long-Chain Acyl-Coa Synthetase 1 Variants With Fasting Glucose, Diabetes, And Subclinical Atherosclerosis, Ani Manichaikul, Xin-Qun Wang, Wei Zhao, Mary K. Wojczynski, Kyle Siebenthall, John A. Stamatoyannopoulos, Danish Saleheen, Ingrid B. Borecki, Muredach P. Reilly, Stephen S. Rich, Karin E. Bornfeldt
Genetic Association Of Long-Chain Acyl-Coa Synthetase 1 Variants With Fasting Glucose, Diabetes, And Subclinical Atherosclerosis, Ani Manichaikul, Xin-Qun Wang, Wei Zhao, Mary K. Wojczynski, Kyle Siebenthall, John A. Stamatoyannopoulos, Danish Saleheen, Ingrid B. Borecki, Muredach P. Reilly, Stephen S. Rich, Karin E. Bornfeldt
Open Access Publications
No abstract provided.
Association Of Functional Impairments And Co-Morbid Conditions With Driving Performance Among Cognitively Normal Older Adults, David B. Carr, Peggy P. Barco, Ganesh M. Babulal, Sarah H. Stout, Anne M. Johnson, Chengjie Xiong, John C. Morris, Catherine M. Roe
Association Of Functional Impairments And Co-Morbid Conditions With Driving Performance Among Cognitively Normal Older Adults, David B. Carr, Peggy P. Barco, Ganesh M. Babulal, Sarah H. Stout, Anne M. Johnson, Chengjie Xiong, John C. Morris, Catherine M. Roe
Open Access Publications
No abstract provided.
The Effects Of Peripheral And Central High Insulin On Brain Insulin Signaling And Amyloid-Β In Young And Old App/Ps1 Mice, Molly Stanley, Shannon L. Macauley, Emily E. Caesar, Lauren J. Koscal, Will Moritz, Grace O. Robinson, Joseph Roh, Jennifer Keyser, Hong Jiang, David M. Holtzman
The Effects Of Peripheral And Central High Insulin On Brain Insulin Signaling And Amyloid-Β In Young And Old App/Ps1 Mice, Molly Stanley, Shannon L. Macauley, Emily E. Caesar, Lauren J. Koscal, Will Moritz, Grace O. Robinson, Joseph Roh, Jennifer Keyser, Hong Jiang, David M. Holtzman
Open Access Publications
No abstract provided.
Analysis Of The Putative Role Of Cr1 In Alzheimer’S Disease: Genetic Association, Expression And Function, Maria I. Fonseca, Shuhui Chu, Aimee L. Pierce, William D. Brubaker, Richard E. Hauhart, Diego Mastroeni, Elizabeth V. Clarke, Joseph Rogers, John P. Atkinson, Andrea J. Tenner
Analysis Of The Putative Role Of Cr1 In Alzheimer’S Disease: Genetic Association, Expression And Function, Maria I. Fonseca, Shuhui Chu, Aimee L. Pierce, William D. Brubaker, Richard E. Hauhart, Diego Mastroeni, Elizabeth V. Clarke, Joseph Rogers, John P. Atkinson, Andrea J. Tenner
Open Access Publications
No abstract provided.
Community Attitudes Toward Mass Drug Administration For Control And Elimination Of Neglected Tropical Diseases After The 2014 Outbreak Of Ebola Virus Disease In Lofa County, Liberia, Joshua Bogus, Lincoln Gankpala, Kerstin Fischer, Alison Krentel, Gary J. Weil, Peter U. Fischer, Karsor Kollie, Fatorma K. Bolay
Community Attitudes Toward Mass Drug Administration For Control And Elimination Of Neglected Tropical Diseases After The 2014 Outbreak Of Ebola Virus Disease In Lofa County, Liberia, Joshua Bogus, Lincoln Gankpala, Kerstin Fischer, Alison Krentel, Gary J. Weil, Peter U. Fischer, Karsor Kollie, Fatorma K. Bolay
Open Access Publications
No abstract provided.
Familial Influences On The Full Range Of Variability In Attention And Activity Levels During Adolescence: A Longitudinal Twin Study, Chun-Zi Peng, Julia D. Grant, Andrew C. Heath, Angela M. Reiersen, Richard C. Mulligan, Andrey P. Anokhin
Familial Influences On The Full Range Of Variability In Attention And Activity Levels During Adolescence: A Longitudinal Twin Study, Chun-Zi Peng, Julia D. Grant, Andrew C. Heath, Angela M. Reiersen, Richard C. Mulligan, Andrey P. Anokhin
Open Access Publications
No abstract provided.
Safety Of Anticoagulation With Uninterrupted Warfarin Vs. Interrupted Dabigatran In Patients Requiring An Implantable Cardiac Device, Shivanshu Madan, Purushothaman Muthusamy, Katie L. Mowers, Darryl A. Elmouchi, Bohuslav Finta, Andre J. Gaun, Alan K. Woelfel, Timothy D. Fritz, Alan T. Davis, Nagib T. Chalfoun
Safety Of Anticoagulation With Uninterrupted Warfarin Vs. Interrupted Dabigatran In Patients Requiring An Implantable Cardiac Device, Shivanshu Madan, Purushothaman Muthusamy, Katie L. Mowers, Darryl A. Elmouchi, Bohuslav Finta, Andre J. Gaun, Alan K. Woelfel, Timothy D. Fritz, Alan T. Davis, Nagib T. Chalfoun
Open Access Publications
No abstract provided.
Safety And Efficacy Of Etomidate And Propofol Anesthesia In Elderly Patients Undergoing Gastroscopy: A Double-Blind Randomized Clinical Study, Qing-Tao Meng, Chen Cao, Hui-Min Liu, Zhong-Yuan Xia, Wei Li, Ling-Hua Tang, Rong Chen, Meng Jiang, Yang Wu, Yan Leng, Chris C. Lee
Safety And Efficacy Of Etomidate And Propofol Anesthesia In Elderly Patients Undergoing Gastroscopy: A Double-Blind Randomized Clinical Study, Qing-Tao Meng, Chen Cao, Hui-Min Liu, Zhong-Yuan Xia, Wei Li, Ling-Hua Tang, Rong Chen, Meng Jiang, Yang Wu, Yan Leng, Chris C. Lee
Open Access Publications
No abstract provided.
Adherence To Pre-Exposure Prophylaxis For Hiv Prevention In A Clinical Setting, Madeline C. Montgomery, Catherine E. Oldenburg, Amy S. Nunn, Leandro Mena, Peter Anderson, Teri Lieger, Kenneth H. Mayer, Rupa Patel, Alexi Almonte, Philip A. Chan
Adherence To Pre-Exposure Prophylaxis For Hiv Prevention In A Clinical Setting, Madeline C. Montgomery, Catherine E. Oldenburg, Amy S. Nunn, Leandro Mena, Peter Anderson, Teri Lieger, Kenneth H. Mayer, Rupa Patel, Alexi Almonte, Philip A. Chan
Open Access Publications
No abstract provided.
Safety Of Two-Year Caloric Restriction In Non-Obese Healthy Individuals, Sergei V. Romashkan, Sai Krupa Das, Dennis T. Villareal, Eric Ravussin, Leanne M. Redman, James Rochon, Manjushri Bhapkar, William E. Kraus
Safety Of Two-Year Caloric Restriction In Non-Obese Healthy Individuals, Sergei V. Romashkan, Sai Krupa Das, Dennis T. Villareal, Eric Ravussin, Leanne M. Redman, James Rochon, Manjushri Bhapkar, William E. Kraus
Open Access Publications
No abstract provided.