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On The Role Of Mitochondria In The Regulation Of Calcium In Motor Nerve Terminals During Repetitive Stimulation, Luis E. Garcia-Chacon
On The Role Of Mitochondria In The Regulation Of Calcium In Motor Nerve Terminals During Repetitive Stimulation, Luis E. Garcia-Chacon
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During repetitive stimulation of motor nerve terminals, mitochondrial Ca2+ uptake limits increases in free cytosolic [Ca2+] and helps ensure faithful neuromuscular transmission. Changes in cytosolic [Ca2+] and in mitochondrial [Ca2+] as well as changes in mitochondrial membrane potential (Psi m) were studied in mouse motor nerve terminals using Ca2+ sensitive indicator and potentiometric dyes, respectively. Trains of action potentials (APs) at 50 to 100 Hz produced a rapid increase in mitochondrial [Ca2+] followed by a plateau which usually continued beyond the end of stimulation. After stimulation, mitochondrial [Ca2+] decayed back to baseline over the course of tens of seconds to …