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The Life-Long Diminution Of Anxiety Response As A Consequence Of Reproductive Experience, Ilan M. Mcnamara
The Life-Long Diminution Of Anxiety Response As A Consequence Of Reproductive Experience, Ilan M. Mcnamara
Master's Theses
Reproductive experience (RE), associated with hormonal fluctuations and enriching environmental stimuli, enhances spatial memory and blunts responses to stress/anxiety. Whereas stress reductions occur during lactation, the persistence of the RE-anxiolytic effects is unclear; and little research has focused on the HP A axis, amygdala, and other anxietyrelated areas. Using an elevated plus maze (EPM), we examined anxiety in nulliparous (NP), primiparous (PP), and multiparous (MP) females (zero, one, or two litters, respectively) at 6, 10, 14, 18, and 22 months of age. Brains were subsequently analyzed for neurodegeneration in dorsal raphe nucleus (DRN). RE significantly dampened anxiety (defined by time …