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Tuning Polymeric Chiral Surfactants For Enhanced Enantiomeric Recognition In Micellar Electrokinetic Chromatography, Jepkoech Tarus
Tuning Polymeric Chiral Surfactants For Enhanced Enantiomeric Recognition In Micellar Electrokinetic Chromatography, Jepkoech Tarus
LSU Doctoral Dissertations
The research presented in this dissertation involves the synthesis, modification, characterization, and the application of polymeric surfactants in micellar electrokinetic chromatography (MEKC). Sodium undecenoyl-L-Leucinate (L-SUL) was synthesized and modified by use of alkali metal counterions, alcohols, and Triton X-102. Characterization of the modified poly-L-SUL was performed in order to elucidate the structural changes on the surfactants by use of four techniques. While surface tensiometry was used for the determination of the critical micelle concentration (cmc), fluorescence measurements were used for the determination of the polarity of the modified polymeric surfactants. The information about the size of the polymeric surfactants was …
Analytical Separations Using Packed And Open-Tubular Capillary Electrochromatography, Constantina P. Kapnissi
Analytical Separations Using Packed And Open-Tubular Capillary Electrochromatography, Constantina P. Kapnissi
LSU Doctoral Dissertations
The goal of the research reported in this dissertation is to develop packed and open-tubular capillary electrochromatographic methods for improved achiral and chiral separations of various classes of analytes. The first part of this research involves the separation of seven benzodiazepines by the use of the packed mode of capillary electrochromatography (CEC) and a 40 cm packed bed of Reliasil 3 μm C18 stationary phase. Optimal conditions were established by varying the mobile phase, the amount of organic modifier, the buffer concentration, the applied voltage, and the column temperature. The second part of this research focuses on the open-tubular …