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Protein Aggregation Studies: Inhibiting And Encouraging Β-Amyloid Aggregation, Jed Paul Aucoin
Protein Aggregation Studies: Inhibiting And Encouraging Β-Amyloid Aggregation, Jed Paul Aucoin
LSU Doctoral Dissertations
This work demonstrates peptide-based aggregation mediation of fibril forming peptides, notably β-amyloid (1-40), Aβ1-40. To achieve the goals of this work, Aβ1-40 aggregation was governed by ionic strength, temperature, and pH. After controlling and reproducing Aβ1-40 aggregate formation (fibrils), each peptide-based aggregation mediator was evaluated for its ability to self-aggregate and to possess surface-active properties. The incorporation of these mediators in Aβ1-40 solutions changed the surface tension and produced aggregate complexes of mediator and Aβ1-40. Evidence that Aβ1-40 fibril formation may be mediated by disorder-to-order transitions has been observed by layer formation …
The Diagnosis Of Dementia In Persons With Mental Retardation: Validating Methods Of Assessment, Joanne Bielecki
The Diagnosis Of Dementia In Persons With Mental Retardation: Validating Methods Of Assessment, Joanne Bielecki
LSU Doctoral Dissertations
The usual assessment instruments for the diagnosis of dementia are often difficult to use among individuals with mental retardation. This study investigates whether a modified method based on Visser et al. (1997) can identify a dementing process. Ninety individuals diagnosed with severe and profound mental retardation were studied. One half of the participants were diagnosed with Down's syndrome. The participants were equally assigned to one of three groups based on perceived risk of dementia. A differential prevalence design was used. Both cross sectional and longitudinal analyses were utilized in this study. Results indicate that the Visser et al. (1997) method …