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Medical Marijuana In Mississippi: A Journalistic View Of Physician Opinions And Patient Education, Michael Pitts

Honors Theses

Medical Marijuana in Mississippi: A Journalistic View of Physician Opinions and Patient Education is an in-depth investigative journalism project examining aspects of the Mississippi Medical Cannabis Program. Specific areas of interest were Mississippi physician opinions on the use medical marijuana and their views on the application of the state’s program as well as an examination into how patients are receiving education on medical marijuana. This project involved interviews of healthcare providers, dispensary staff, and patients, in addition to background research that was used to formulate interview questions, determine areas of interest and add necessary context. This project occurred during the …

The Effect Of Cannabinoids And Terpenes On The Activation Of Hmc3 Microglial Cells, Mohamed Marzouk

Honors Theses

Life expectancies of people living with HIV have significantly lengthened due to the availability of antiretroviral therapies. Despite their ability to increase survival, these treatments do not “cure” HIV, nor do the stop the onset of neurological symptoms associated with infection, termed neuroHIV. NeuroHIV describes a myriad of neurological impairments including mood disorders (depression and anxiety), cognitive impairment, neuropathic pain, and motor disinhibition that reduce quality of life for people living with HIV. Mechanistically, the neurological impairments may involve actions of neurotoxic proteins directly produced by the virus. One of these proteins that has been well-characterized is the HIV trans …

Medical Cannabis In Mississippi: Practitioner Education And Continuing Research, Andrea Cleveland

Honors Theses

Use of medical cannabis in Mississippi was legalized in February 2022 following many years of cannabis research at the University of Mississippi. Issues immediately became apparent, beginning with the lack of education about medical cannabis among providers. A 2017 study showed that the majority of physicians are not exposed to information about medical cannabis despite its legalization in 37 states. Another issue with Mississippi’s medical cannabis program is the cost of the product itself. The most effective way to decrease spending on medication is for patients to have access to medication that is guaranteed to work. Further research on cannabis …

Effects Of Cannabichromene On Pain And Neuroinflammation In Hiv-1 Tat Transgenic Mice, Sydney Wheeler

Honors Theses

HIV-1 TransActivator of Transcription (Tat) is a vital regulatory protein involved in HIV replication and implicated in development of HIV-associated pain and neurocognitive deficits. Tat is thought to contribute to these pathologies through proinflammatory pathways. Developing mechanisms to curb Tat-mediated inflammation is a key step in improving the quality of life of those living with HIV. Both recreational and medicinal cannabis use is prevalent among many people living with HIV; given this prevalence and the perceived anti-inflammatory benefits of cannabis use, it is important to investigate how chemical constituents of cannabis may impact HIV. In the present study, the effects …

Efficacy Of Δ-9-Tetrahydrocannabinol For Hiv-Related Neuropathic Pain, Kaia Horne

Honors Theses

Despite the availability and success of antiretroviral therapeutics, ~30% of patients living with HIV experience neuropathic pain that is often intractable. The mechanisms are not known, but there is evidence to support a role for the HIV virotoxins, Tat and/or gp120, which can damage or degenerate neurons and peripheral nerves. One mechanism by which Tat and gp120 promote nerve damage involves the stimulation of proinflammatory cytokine production from immune cells which can damage or kill bystander cells. Notably, compounds found in Cannabis exert anti-inflammatory effects and many studies report HIV patients to consume more marijuana than seronegative individuals. When people …

The Green Wave: Effects Of Legal Marijuana On The Labor Market., Sara Varon

Honors Theses

In this paper I examine the relationship between the introduction of recreational marijuana laws and the labor market. First, using Google Trends data I find evidence that states that undergo the treatment of recreational marijuana legalization will likely experience a large and significant increase in search volume terms related to marijuana demand following the implementation of marijuana regulations. Using this same data set, I find support for the theory that as marijuana legalization becomes more entrenched within each individual state, public interest for marijuana also increases which allows for the use of Google Trends data as a proxy for legalization …

Reconceptualizing Cannabis, Julia Peoples

Honors Theses

Inflammatory rhetoric and increasingly punitive drug policies dominated marijuana politics in the past. Today, as 36 have legalized cannabis in some form and 17 states have legalized recreational marijuana, the federal government continues to perpetuate policies of the past. The following analysis investigates rhetoric and policies that led to the War on Drugs as well as their outcomes, the dramatic shift in public opinion as states began to legalize marijuana, and the successes and failures of state cannabis programs to identify gaps within the MORE Act, the ideal policy, and politically viable incremental change. State programs are incapable of …

Impacts Of Embryonic Exposure To Cannabidiol Or ∆9-Tetrahydrocannabinol On Zebrafish (Danio Rerio) Frailty In F0 And F1 Generations, Anika Faruque

Honors Theses

Exposure to cannabinoids during critical development periods has increased with epileptic children being commonly prescribed CBD for seizures and pregnant women taking it recreationally. Many studies have been done on the possible benefits and drawbacks of cannabinoid exposure on the human brain, but not much is known about how it can affect the developing brain long-term. To see the potential adverse effects of cannabinoid exposure during critical stages of development and discover potential developmental origins of disease in consuming cannabinoids during embryogenesis, zebrafish embryos (6-96 hours post fertilization) were exposed to varying concentrations of CBD (0.02, 0.1, 0.5 µM), THC …

The Green Rush, Alexis N. Stein

Honors Theses

Hemp, Cannabis, Weed, Marijuana, Pot, Bud, Reefer, Grass…the nicknames go on and on, but how did a plant that was once widely accepted become a Schedule I substance according to the United States Federal Government? In order to fully understand this question, we must first look at the history of hemp from its origins in 8,000 BCE to present day. This information will allow us to better understand the history of cannabis and how it has shaped the landscape for the growing cannabis industry today.

The Relation Between Self-Reported Alcohol And Cannabis Use And Prospective Memory In College Students, Emily Koberstein

Honors Theses

Emily Koberstein, Stephanie Clancy Dollinger, Ph.d, & Sherrie Parks, M.A.

Department of Psychology

The Relation between Self-Reported Alcohol and Cannabis Use and Prospective Memory in College Students

The aim of this study is to see if there is a relation between drug use and prospective memory performance. Prospective memory is the ability to remember to do something in the future and is a vital aspect of everyday living. Prospective memory can be broken down into short-term, long-term and event-based or time-based components. Most research on prospective memory has primarily examined differences between young and old adults (e.g., Einstein & McDaniel, …

Cannabinoid Modulation Of Microglial Activation In Multiple Sclerosis, Natalie Shea Lemons

Honors Theses

Multiple Sclerosis (MS) is a neurodegenerative disease that is estimated to affect 400,000 Americans. There is no cure for MS and some treatments at this point are toxic to patients. Dr. Lori Hensley's lab is researching two drugs that could potentially be used to treat MS without toxic effects. Previous work in the lab shows ajulemic acid, a synthetic molecule similar to metabolites from the cannabis plant, selectively suppresses markers of the inflammatory response. worked on the mechanism of ajulemic acid's action by investigating the roles of several candidate receptors in mediating these observed effects.