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Use Of Crispr To Develop A Follicle Stimulating Hormone Receptor Knockout In Human Granulosa Cells To Study Lipid Raft Residency, Jenna Pradhuman
Use Of Crispr To Develop A Follicle Stimulating Hormone Receptor Knockout In Human Granulosa Cells To Study Lipid Raft Residency, Jenna Pradhuman
Honors Theses
Human follicle stimulating hormone (hFSH) is a protein hormone responsible for stimulating the gonads and is necessary for regulating reproductive systems in both females and males. The actions of hFSh are carried out by the hFSH receptor (hFSHR), a seven transmembrane receptor that belongs to the G protein-coupled receptor family. Once FSH activates its receptor, the G protein inside the cell that is associated with the receptor is activated and starts a cascade of signaling that results in activation of protein kinase A (PKA) and the p44/42 MAP kinase (MAPK). The activation of these secondary proteins is responsible for follicular …
Quantification Of Hfshr Signaling To Determine Lipid Raft Residency, Gregory Geisel
Quantification Of Hfshr Signaling To Determine Lipid Raft Residency, Gregory Geisel
Honors Theses
Human follicle stimulating hormone (hFSH) is a gonadotropin responsible for regulating reproductive systems by stimulation of Sertoli cells in males and granulosa cells in females. The hFSH receptor (hFSHR) is a seven transmembrane receptor that belongs to the G protein coupled receptor family. The receptor is functionally connected to a G protein on the inside of the cell. Once FSH activates its receptor, a cascade of signaling begins, resulting in the activation of adenylyl cyclase, which increases the intracellular levels of cAMP. In addition, hFSHR stimulation also activates the p44/42 MAP kinase. The spike in cAMP activates the enzyme protein …
The Search For Binding Partners Of The Chlamydia Trachomatis Phosphatase Cpp1, Lea Matschke
The Search For Binding Partners Of The Chlamydia Trachomatis Phosphatase Cpp1, Lea Matschke
Honors Theses
Chlamydia trachomatis is a Gram negative, obligate intracellular bacterium responsible for the most common reportable bacterial sexually transmitted infection in the United States and the leading infectious cause of preventable blindness worldwide. This pathogen undergoes a unique biphasic developmental cycle where it alternates between its infectious form, termed the elementary body (EB), and its replicative form, termed the reticulate body (RB). We hypothesize that reversible phosphorylation regulates the differentiation of the bacterium between these two forms. In order to study phosphorylation in Chlamydia, it is necessary to examine the role of individual kinases and phosphatases in the organism. My …
“La Política Del Avestruz”: The Regulation Of The Black Market For Medical Abortion In Chile, Sophia M. Bartels
“La Política Del Avestruz”: The Regulation Of The Black Market For Medical Abortion In Chile, Sophia M. Bartels
Honors Theses
This thesis seeks to answer the overarching question of how the black market for medical abortion is regulated in Chile. In answering this question, this thesis responds to the two sub questions: why is the Chilean government ineffective at regulating the black market for medical abortion in Chile, and how have non-governmental actors filled this vacuum through informal regulation? Although the Chilean government has one of the highest levels of state capacity in Latin America, it has surprisingly allowed this black market to exist in almost complete impunity. In this thesis, I argue that although the Chilean government has the …