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Science And Sadness: Critiques On How We Handle Alzheimer’S Disease And Dementia, Katherine Martinez

Honors Theses

In our society, an individual’s worth is tied to the state of their cognitive function which affects the discourse about neurodegenerative illnesses, causing it to mostly fall under two branches: “The Dread” and “Science as the Holy Grail”. “The Dread” addresses how Alzheimer’s Disease (AD) and other dementias are typically perceived as devastating illnesses to be feared. “Science as the Holy Grail” represents the hope and faith that is invested into potential technoscientific developments without the guarantee of any consequential results. Limiting the narrative to these two categories negatively impacts the quality of life (QOL) of AD patients, caregivers, and …

The Assessment Of Senior-Level Nursing Students’ Knowledge Regarding Informal Caregiver Role Strain And The Presence Of Role Strain In Informal Caregivers Of Dementia Patients, Amanda Diard

Honors Theses

The goal of this study was to assess senior-level nursing students’ knowledge of informal caregivers of dementia patients, their confidence in their ability to work with informal caregivers, and how well they believe their nursing program prepared them to assist informal caregivers. Seventeen (n = 17) Bachelor of Science (BSN) nursing students participated in the study. A twenty-four-question survey was emailed to both junior- and senior-level students in the five-semester BSN program at the University of Southern Mississippi (USM). Responses from students of different levels were collected to determine if an accurate understanding of informal caregivers of dementia patients …

Hippocampal Connectivity In Parkinson's Disease, Landis Llewelyn

Honors Theses

Background: This thesis was conducted in order to investigate possible connections between functional connectivity of the hippocampus in individuals who have Parkinson’s disease.

Methods: The MRI images, the clinical data, and the demographic data of 93 individuals with PD and 18 individuals without PD were obtained from the Parkinson's Progression Markers Initiative. Resting-state fMRI data from a group of PD patients was compared to a control group of non-PD patients by using previously published methods with FMRIB Software Library (FSL) as well as Analysis of Functional Neuroimages (AFNI).

Results: Compared to the control (non-PD) group, results bilaterally showed lesser connectivity …

Nurses' Perceptions Of Person-Centered Care In Long-Term Care, Sophia A. Lefevers

Honors Theses

Over the years, the average lifespan of Americans has slowly increased, nearing almost 79 years of age. This increase has resulted in individuals ultimately becoming more likely to experience one of many underlying health conditions, such as dementia. The result of a condition like dementia is the requirement of more specialized care than an individual or their family can provide for them. This results in them seeking more skilled and focused care, such as within long-term care facilities. One of the goals of long-term care facilities is to provide individuals with a high level of care that promotes their quality …

Neuro-Exergaming For Older Adults With Mild Cognitive Impairment (Mci): A Single Bout Of Interactive Physical And Cognitive Exercise (Ipaces V2.5), Alexa Puleio

Honors Theses

Mild Cognitive Impairment (MCI) poses a serious risk to the older population. This disease may be a precursor to a more debilitating dementia, such as Alzheimer’s Disease (AD), and it affects the cognitive abilities as well as overall quality of life of those who suffer from it (Alzheimer’s Association, 2014). Finding preventative ways to combat these neurodegenerative illnesses is imperative for our increasing older population at risk. Prior research has shown benefits to cognition from physical exercise (Colcombe & Kramer, 2003); however, only a fraction of older adults actually achieve recommended levels (Chodzko-Zajko et al., 2009). Some researchers have explored …

Linking Key Factors Of Quality Dementia Care: Knowledge And Self-Efficacy, Sophie E. Miller

Honors Theses

Dementia-related changes in cognition, memory, and personality can have wide-ranging impacts on individuals, families, and healthcare systems (Plassman et al., 2007); including caregiver burnout, disruption of family life, and costly care requirements (Graneheim, Johansson, & Lindgren, 2014). Dementia has become a global issue; 46 million people worldwide have dementia and $600 billion are spent on dementia-related care every year (Farina al., 2016). Certified nursing assistants (CNAs) generally assume the majority of day-to-day care and are a vital component of providing quality, person-centered services to patients with dementia in residential care (Burke & Orlowski, 2015). The purpose of this study was …

Thrilling Monotony: A Summer Of Alzheimer's Research, Baronger Dowell Bieger

Honors Theses

The primary genetic risk determinant for late-onset Alzheimer's disease is the apolipoprotein E gene (APOE). Variations in this gene produce three different isoforms of the apolipoprotein E protein (ApoE): ApoE2, ApoE3, and ApoE4. ApoE# is the most common isoform, so rates of LOAD among other genotypes are indexed to this variant. ApoE2 is rather rare, but its carriers are less likely to get LOAD; when they do, they get it later. The second most common variant is ApoE4, and its carriers are significantly more likely to get LOAD. They also tend to succumb earlier. Once developed, LOAD is characterized by …

Exploring The Interactions Between Interleukin-8 (Il8) And Amyloid-Β (Aβ) Peptide In Traumatic Brain Injury, Olivia G. Gibson

Honors Theses

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive dysfunction and memory loss, and pathologically characterized by amyloid-beta (Aβ) plaques and inflammation. Recent research has shown that these Aβ plaques are also found in traumatic

brain injury (TBI) patients. This discovery has led to a proposed pathway leading from traumatic brain injuries to dementia, more specifically AD. After a TBI, human granulin-A (GRN) and interleukin-8 (IL8) are released and the number of elastases in the brain increases in response to the inflammation response. IL8 is a cytokine that is released in acute inflammation responses, and the levels of IL8 …

Neuropsychological And Neurophysiological Effects Of Low-Intensity Strengthening Exercise On Cognition, Vadim V. Yerokhin

Honors Theses

With the growing aging population, it’s becoming increasingly important to find ways to either deter or prevent dementia. To date, most research has concentrated on the effects of aerobic exercise on cognition. Unfortunately, a large portion of older adults are often contraindicated to perform aerobic exercise due to different risk factors, which increase with age. Alas, alternate ways of exercise are necessary. Low-intensity strengthening exercise is a type of exercise aimed at improving balance and strengthening muscles without requiring one to overstrain. The current 11-week long exercise study test neuropsychological effects of exercise with a neuropsychological battery and neurophysiological effects …