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Monitoring Of Dna Polymerase Theta Movements Through Fret Analysis, Ashley Rebelo
Monitoring Of Dna Polymerase Theta Movements Through Fret Analysis, Ashley Rebelo
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DNA polymerases are enzymes used for DNA replication during cell division and can be specialized for DNA repair. DNA Polymerase Theta (Pol θ) is the predominant polymerase involved in alternative double-stranded break repair and is upregulated in breast cancer. It is errorprone as it does not accurately match the nucleotide on a DNA template with the correct complementary base. This inaccuracy affects the overall fidelity of the enzyme, a biochemical process that looks at the ability of a polymerase to “read” the template DNA and select the right nucleotide before polymerization. Polymerization for most DNA polymerases involves a global conformational …