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Relationship Of Dna Methylation With Cardiovascular Fitness And Body Composition, Mihaela A. Ciulei
Relationship Of Dna Methylation With Cardiovascular Fitness And Body Composition, Mihaela A. Ciulei
Honors College Theses
Global DNA Methylation (GDM), an epigenomic modification has been linked to the development of cardiovascular disease and its risk factors. Our focus was to identify potential relationships between epigenetic alterations and both cardiovascular fitness and body composition measures. Purpose: As increases in aerobic fitness have a beneficial effect on cardiovascular disease, one purpose was to determine if a relationship was evident between global DNA methylation and VO2max. A secondary purpose was to determine if the relationship extends to body composition measured via Dual X-ray Absorbtometry (DXA). Methods: Fifty-two (male n=25, female n=27) subjects provided a blood sample for DNA …