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Immunomodulatory Roles Of Endotoxin And Glutaraldehyde In The Development Of Latex Allergy, Michael D. Howell
Immunomodulatory Roles Of Endotoxin And Glutaraldehyde In The Development Of Latex Allergy, Michael D. Howell
Graduate Theses, Dissertations, and Problem Reports
Although much data has been obtained related to the clinical manifestations of latex allergy and the characterization of the protein allergens, little is known regarding the natural history of the disease. These studies were undertaken to demonstrate the immunological relevance of both dermal and respiratory exposure in the development of latex allergy and to investigate the role of co-exposure by these routes to other agents in the health care environment on the development of NRL sensitization.;An initial study in female BALB/c mice demonstrated comparable rates of induction of latex specific IgE following dermal and respiratory latex exposure, demonstrating the importance …
Sport Fish Consumption Advisory For West Virginia, William Alvin Warnick
Sport Fish Consumption Advisory For West Virginia, William Alvin Warnick
Graduate Theses, Dissertations, and Problem Reports
The risk based sport fish consumption advisory protocol, West Virginia Sport Fish Consumption Advisory Guide (the Guide), was drafted for the state. Fish were collected from ten West Virginia sites (5 previously identified as contaminated, 5 previously identified as uncontaminated). Fish samples were collected, processed and analyzed for total mercury concentration and Aroclors (PCBs). Recommended meal frequencies were calculated from contaminant levels and based on the Guide. Mean fillet sample contaminant levels were compared to composite sample levels and found to require the same level or in one case a more protective of consumption advisory. Ten composite samples had Aroclor …
Vanadate-Induced Cell Cycle Regulation And Its Signal Transduction Pathway, Zhuo Zhang
Vanadate-Induced Cell Cycle Regulation And Its Signal Transduction Pathway, Zhuo Zhang
Graduate Theses, Dissertations, and Problem Reports
Vanadate is potent toxic and carcinogenic agent. The mechanisms of its toxic and carcinogenic actions are still under investigation. Cell cycle arrest is an important mechanism in maintaining genomic stability and integrity in response to environmental stress. The present study investigated the possible mechanisms involved in vanadate-induced cell cycle arrest and its signal transduction pathway. The results show that vanadate caused G2/M phase arrest A549 cells. p21 and cdc25C affected on cyclin B/cdc2 complex, resulting in the cell cycle arrest at G2/M phase. p38 and extracellular signal-regulated protein kinase (ERK) were involved in the regulation of these cell cycle regulatory …
Modulation Of Thiols And Pulmonary Immune Responses Due To Diesel Exhaust Particle (Dep) Exposure, Nabil Hussain Al-Humadi
Modulation Of Thiols And Pulmonary Immune Responses Due To Diesel Exhaust Particle (Dep) Exposure, Nabil Hussain Al-Humadi
Graduate Theses, Dissertations, and Problem Reports
Environmental exposure to diesel exhaust particles (DEP) has been of concern because of its potential contribution to the increased prevalence of acute and chronic airway diseases. The objective of this study was to investigate the role of thiol changes (due to DEP exposure) in immune responses. Rats were exposed to OVA, DEP, or both by intratracheal instillation (IT) and/or inhalation. IT-DEP exposure significantly increased the inflammatory parameters and thiol levels in both Sprague-Dawley and Brown Norway rats. Exposure to DEP and/or OVA resulted in significant increases in neutrophils, LDH, total protein, and albumin content in lavage fluid. Alveolar macrophage (AM) …
Combustion Analysis And Particulate Mutagenicity Characterization For A Single-Cylinder Diesel Engine Fueled By Fischer -Tropsch Derived Liquids, Michael Hayden Mcmillian
Combustion Analysis And Particulate Mutagenicity Characterization For A Single-Cylinder Diesel Engine Fueled By Fischer -Tropsch Derived Liquids, Michael Hayden Mcmillian
Graduate Theses, Dissertations, and Problem Reports
Further growth of diesel engines in the light-duty and heavy-duty vehicular markets is closely linked to the potential health risks of diesel exhaust. Cleaner burning fuels, such as those derived from natural gas via the Fischer-Tropsch (FT) process, offer a potentially economically viable alternative to standard diesel fuel. As part of this study, a two-liter, single-cylinder, four-stroke direct-injected engine was instrumented for in-cylinder pressure measurements. The emissions and performance data from engine operation with Federal low sulfur No. 2 diesel fuel (DF) and natural gas derived FT fuel were compared. Also as part of the study, an investigation was carried …
In Vitro Genotoxicity Investigations Of Jet Fuel, Shawna M. Jackman
In Vitro Genotoxicity Investigations Of Jet Fuel, Shawna M. Jackman
Graduate Theses, Dissertations, and Problem Reports
The 60 billion gallons of jet propulsion fuels consumed worldwide create an exposure situation to over two million military and civilian personnel per year. The potential mutagenic, genotoxic and cytotoxic potency of military jet fuel was investigated in this study through in vitro systems such as human peripheral lymphocytes and metabolically competent hepatic cell lines. A battery of genotoxicological evaluations is employed, focusing on the comet assay to examine the induction of DNA damage. Cellular exposures to fuel were carried out directly and indirectly with an ethanol (EtOH) carrier. The fuel was found to be nonmutagenic with and without metabolic …