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Secretin-Modulated Potassium Channel Trafficking As A Novel Mechanism For Regulating Cerebellar Synapses , Michael Williams

Graduate College Dissertations and Theses

The voltage-gated potassium channel Kv1.2 is a critical modulator of neuronal physiology, including dendritic excitability, action potential propagation, and neurotransmitter release. However, mechanisms by which Kv1.2 may be regulated in the brain are poorly understood. In heterologous expression systems Kv1.2 is regulated by endocytosis of the channel from the plasma membrane, and this trafficking can be modulated by adenylate cyclase (AC). The goal of this dissertation was to determine whether AC modulated endocytic trafficking of endogenous Kv1.2 occurred in the mammalian nervous system. Within the brain, Kv1.2 is expressed at its highest levels in the cerebellar cortex. Specifically, Kv1.2 is …