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Characterizing The Anxiolytic Potential And Synergistic Efficacy Of Cannabidiol And D-Limonene, Nathashi Jayawardena

Electronic Thesis and Dissertation Repository

Emerging evidence has elucidated the anxiolytic properties of the cannabis-derived phytochemicals cannabidiol (CBD) and d-limonene and the ‘Entourage Effect’ wherein, multiple components of cannabis synergize to produce stronger effects than their pure counterparts. However, no studies have yet explored this effect in combinations of CBD and limonene. Thus, the present thesis investigated the anxiolytic and synergistic potential of concurrently administered intra-nucleus accumbens shell CBD (1 ng/0.5 μl or 5 ng/0.5 μl) and inhaled limonene (200 μl or 2000 μl). Additionally, the role of the 5-HT1A receptor in mediating these effects was examined by co-application of the antagonist NAD299 and by …

Development Of A Recombinant Brewing Yeast To Produce Beer From Hemp Extract (Cannabis Sativa L.), Mehmet Ugur Gulmen

Electronic Thesis and Dissertation Repository

The Cannabis industry is a rapidly-growing market in Canada. With the legalization of edible products in 2019, many cannabis-derived candies, baked goods, beverages appeared on shelves. Cannabis beer can be brewed by replacing barley with pretreated cannabis plant. However, using a traditional brewing yeast to brew cannabis beer will result in incomplete fermentation which will affect the beer’s composition and flavour because traditional brewing yeasts are not able to utilize xylose which is an abundant carbohydrate in lignocellulosic extracts. Using a recombinant strain of a brewing yeast and a xylose-fermenting yeast can overcome this issue. The work presented in this …

The Effects Of Maternal Delta-9-Tetrahydrocannabinol And Cannabidiol Exposure On Fetal Heart Development In Mice, Gregory Robinson

Electronic Thesis and Dissertation Repository

Up to 22.6% of pregnant women consume cannabis during pregnancy despite the uncertainty of teratogenicity of the main ingredients in cannabis, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). This study tested the hypothesis that gestational THC and CBD exposure leads to heart abnormalities. Daily, oral THC exposure induced heart abnormalities in 68% of offspring with three main phenotypes including thickened semilunar valves, ventricular myocardial hypertrophy and hypoplastic coronary arteries in fetuses, and postnatal cardiac dysfunction. Altered gene expression of key cardiogenic regulators, increased proliferation, and reduced epicardial epithelial-to-mesenchymal-transition were demonstrated implicating potential mechanisms responsible for these abnormalities. Also, maternal CBD exposure resulted …

Cannabis For Therapeutic Purposes: Older Adult Perspectives, User Characteristics And Motivations For Use, Lean Fiedeldey

Electronic Thesis and Dissertation Repository

Use of cannabis among adults 55 years of age and older is increasing. In Q4 of 2018, slightly over half of cannabis users used for therapeutic purposes at least once, where many reported using for both medical and non-medical reasons (mixed use). Research on older adults regarding the use of Cannabis for Therapeutic Purposes (CTP) is fragmented and there are no comprehensive or in-depth studies on their perceptions or self-reported motivations. Understanding in these areas is important to inform policy that takes the protection of public health and safety as central aims. Does policy affect one of, if not both, …

Patterns Of Problem Behaviours Among A Representative Sample Of Youth In Ontario, Chantal Williams

Electronic Thesis and Dissertation Repository

Behavioural addictions among adolescents are becoming a growing public health concern. It is well established that problem behaviours, particularly substance use behaviours, tend to cluster together. Some research indicates that gambling is associated with substance use, aligning with Problem Behaviour Theory, which suggests that problem behaviours stem from an underlying disposition toward deviance. This study sought to assess whether a) behavioural addictions, including gambling, video gaming and technology use, cluster together and with substance use and b) profiles of problem behaviours are associated with age, race, socioeconomic status, grade achievement, school connectedness, and antisocial behaviour in the total sample and …

The Constitutionality Of Restrictions On Recreational Cannabis Advertising: Balancing Public Health And Freedom Of Expression, Melanie L. Mcphail

Electronic Thesis and Dissertation Repository

On April 20, 2016, Health Minister Jane Philpott announced that legislation legalizing recreational marijuana would be introduced in Spring 2017, with the goal of keeping marijuana out of the hands of children and profit out of the hands of criminals. Bill C-45, An Act Respecting Cannabis passed the second reading in the House of Commons, and contains restrictions on advertising cannabis, with a few exceptions. Advertising is recognized as a protected form of expression under the Charter of Rights and Freedoms, so if the government infringes on this right, they must be able to prove that it is justified in …

Canada's Marihuana Medical Access Regulations: Up In Smoke, Carolynn Conron

Electronic Thesis and Dissertation Repository

The Supreme Court of Canada has interpreted the constitutional principles entrenched in the Canadian Charter of Rights and Freedoms to mean that everyone in Canada has a constitutional right to access necessary medical treatment without fear of criminal sanction. The latest research suggests cannabis (marihuana) provides a unique medicinal benefit that, for some individuals, is necessary. The federal criminal prohibition of cannabis deprives many individuals of a potentially beneficial medicine and stigmatizes them with a criminal record.

Without a valid medical cannabis access system, the criminal prohibition is invalid. The current Marihuana Medical Access Regulations were recently struck down. Parliament …