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The Role Of Non-Canonical Wnt/Planar Cell Polarity Signalling In Breast Cancer Progression, Connor D. Macmillan
The Role Of Non-Canonical Wnt/Planar Cell Polarity Signalling In Breast Cancer Progression, Connor D. Macmillan
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The role of planar cell polarity (PCP) signalling in breast cancer is unclear, as evidence shows that activation of this pathway with WNT5A can either promote or inhibit progression. Using the 21T cells, which represent distinct stages of breast cancer progression when grown in a mouse xenograft model (21PT, atypical ductal hyperplasia; 21NT ductal carcinoma in situ; 21MT-1, invasive mammary carcinoma), I hypothesized that WNT5A will promote progression only when VANGL1, another component of PCP signalling, is elevated.
Each 21T cell line showed distinct stage-specific morphologies when grown in a Matrigel “on-top” assay. WNT5A overexpression promoted progression to an invasive …