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Legs And Hills, Aidan Attema

Electronic Thesis and Dissertation Repository

Relatively longer leg length is a feature of the genus Homo that is often argued to have evolved due to selective pressures from a greater reliance on endurance running. Within the genus Homo, however, Neanderthals had relatively short legs with shorter tibiae – a characteristic that has been hypothesized to be a hindrance for running yet advantageous for locomoting on sloped terrains. This thesis tests three hypotheses relating to lower limb proportions and running performance: does morphological variability correspond with a) speed on flat and uphill terrain during a workout completed by cross-country athletes, or b) athletic performance during …

Coevolution Of Hosts And Pathogens In The Presence Of Multiple Types Of Hosts, Evan J. Mitchell

Electronic Thesis and Dissertation Repository

How will hosts and pathogens coevolve in response to multiple types of hosts? I study this question from three different perspectives. First, I model a scenario in which hosts are categorized as female or male. Hosts invest resources in maintaining their immune system at a cost to their reproductive success, while pathogens face a trade-off between transmission and duration of infection. Importantly, female hosts are also able to vertically transmit an infection to their newborn offspring. The main result is that as the rate of vertical transmission increases, female hosts will have a greater incentive to pay the cost to …

Rates And Patterns Of Indels In Hiv-1 Gp120 Within And Among Hosts, John Lawrence Palmer

Electronic Thesis and Dissertation Repository

Insertions and deletions (indels) in the HIV-1 gp120 variable loops modulate sensitivity to neutralizing antibodies and are therefore implicated in HIV-1 immune escape. However, the rates and characteristics of variable loop indels have not been investigated within hosts. Here, I report a within-host phylogenetic analysis of gp120 variable loop indels, with mentions to my preceding study on these indels among hosts.

We processed longitudinally-sampled gp120 sequences collected from a public database (n = 11,265) and the Novitsky Lab (n=2,541). I generated time-scaled within-host phylogenies using BEAST, extracted indels by reconstructing ancestral sequences in Historian, and estimated variable loop indel rates …

Multi-Scale Evolution Of Virulence Of Hiv-1, David W. Dick

Electronic Thesis and Dissertation Repository

HIV-1 is a rapidly replicating retrovirus that faces two distinct fitness landscapes: within-host HIV-1 faces viral competition for host cells and for escape from the immune system, and between hosts HIV-1 faces a transmission bottleneck in which the majority of new infections are started by a single virus strain. Possibly as a result of these conflicting selective pressures, the rate of evolution of HIV-1 tends to be greater within-host than between hosts.

A current hypothesis for this difference in evolutionary rates is that the HIV-1 latent reservoir acts to archive virus for later transmission. We offer a related but complimentary …

Characterizing Mekk1: Candidate Behavioural Isolation Gene, Caryn Dooner

Electronic Thesis and Dissertation Repository

Behavioural isolation can occur due to divergence in aspects of courtship and mating, and can contribute to reproductive isolation. The purpose of this study is to determine how a gene, Mekk1, contributes to female rejection behaviour between D. melanogaster and D. simulans. Unique polymorphisms were identified within D. simulans Mekk1 that could contribute to behaviour, most of which are non-coding. Both transcripts of Mekk1 appear to be expressed at similar levels in D. simulans and D. melanogaster. These data also indicate that Mekk1 may be expressed in a specific region of the brain called the mushroom body, …

The Genetic And Environmental Basis For Chc Biosynthesis In Drosophila, Heather Ke Ward

Electronic Thesis and Dissertation Repository

Cuticular hydrocarbons (CHCs) are produced by insects and primarily used to prevent desiccation. In Drosophila, certain compounds have secondary roles as infochemicals that may act during courtship to influence mate choice. Certain CHCs may stimulate courtship with heterospecifics or act to repel conspecifics. The CHC profile produced by an individual is the result of the interaction between its genetic background and the environment, though the genes that underlie species differences in CHC production and how the environment can modulate the abundance of individual compounds within a species is not well known. Here, candidate gene CG5946 was found to be …

Evolution, Paleoecology, And Paleobiogeography Of The Late Ordovician Brachiopod Fauna Of Laurentia, Colin D. Sproat

Electronic Thesis and Dissertation Repository

During the early Katian (Late Ordovician), the North American craton was being inundated due to a major eustatic sea level rise and regional subsidence associated with the ongoing Taconic orogeny. The Trentonian brachiopod fauna, as a dominant group of the marine shelly benthos at that time, evolved and invaded the expanding epicontinental seas.

Three Trentonian brachiopod lineages were studied to trace their evolution. The Rostricellula-Rhynchotrema-Hiscobeccus lineage was characterized by an increase in shell size, globosity, and frilled lamellae, with Hiscobeccus becoming a prominent component of the Late Ordovician epicontinental brachiopod fauna.

Parastrophina is a widely reported but non-dominant taxon of …

First Major Appearance Of Brachiopod-Dominated Benthic Shelly Communities In The Reef Ecosystem During The Early Silurian, Cale A.C. Gushulak

Electronic Thesis and Dissertation Repository

The early Silurian reefs of the Attawapiskat Formation in the Hudson Bay Basin preserved the oldest record of major invasion of the coral-stromatoporoid skeletal reefs by brachiopods and other marine shelly benthos, providing an excellent opportunity for studying the early evolution, functional morphology, and community organization of the rich and diverse reef-dwelling brachiopods. Biometric and multivariate analysis demonstrate that the reef-dwelling Pentameroides septentrionalis evolved from the level-bottom-dwelling Pentameroides subrectus to develop a larger and more globular shell. The reef-dwelling brachiopods in the paleoequatorial Hudson Bay Basin were more diverse than contemporaneous higher latitude reef-dwelling brachiopod faunas, with ten distinct …

Evaluation Of Mertk Evolution And Efferocytosis Signalling, Amanda L. Evans

Electronic Thesis and Dissertation Repository

The TAM (TYRO3, AXL, and MERTK) family of receptor tyrosine kinases allow phagocytes to engage in the phagocytic removal of apoptotic cells. Although all three members of the TAM family are structurally homologous and function in a similar fashion, both human genome-wide association studies and knockout mice models have demonstrated that MERTK is the critical member of the TAM family for maintaining homeostasis. In this thesis, an evolutionary analysis was used to provide insight into the function of MERTK. Selection analysis in primates unexpectedly revealed a high degree of recent positive selection in MERTK’s signal peptide and transmembrane domain, …

The Evolution Of Kin Recognition, Timothy Ja Hain

Electronic Thesis and Dissertation Repository

The discovery that many animals are promiscuous has challenged the importance of Hamilton’s Rule because it reduces the net benefits of helping nestmates. To resolve this challenge, biologists have investigated animals’ abilities to determine degrees of relatedness among individuals using kin recognition mechanisms. I conducted a literature review and found that most animals use one of two mechanisms: “familiarity” whereby kin are remembered from interactions early in life, such as in a nest, or “phenotype matching” whereby putative kin are compared to a template of what kin should look, smell, or sound like based on relatives encountered during early life …

Rethinking Empathy: Value And Context In Motivation And Adaptation, O'Neal Buchanan

Electronic Thesis and Dissertation Repository

The broad aim of this dissertation is to present an alternative approach to empathy research. The three main questions raised are: What is empathy? How do its component psychological processes become active and operate together? How did empathy evolve? In answering these questions, most researchers have started from a conventional approach that can be described as focusing on short-term phenomena “inside the head” of an individual, evidence that is gathered exclusively in a laboratory environment, and neurocognitive processes that are universally shared by all humans.

A problem with the conventional approach is that it makes social and normative issues in …

Evolutionary And In Silico Analysis Of The Antiviral Trim22 Gene, Jenna Kelly

Electronic Thesis and Dissertation Repository

Tripartite motif protein 22 (TRIM22) is an evolutionarily ancient interferon-induced protein that been shown to potently inhibit human immunodeficiency virus (HIV), hepatitis B virus (HBV), and influenza A virus (IAV) replication. Altered TRIM22 expression levels have also been linked to autoimmune disease, cancer, and cellular proliferation. Despite its important role in a number of biological processes, the factors that influence TRIM22 expression and/or antiviral activity remain largely unknown. To identify key functional sites in TRIM22, we performed extensive evolutionary and in silico analyses on the TRIM22 coding region. These tools allowed us to pinpoint multiple sites in TRIM22 that have …

Strata, Soma, Psyche: Narrative And The Imagination In The Nineteenth-Century Science Of Lyell, Darwin, And Freud, Pascale M. Manning

Electronic Thesis and Dissertation Repository

My dissertation, “Strata, Soma, Psyche: Narrative and the Imagination in the Nineteenth-Century Science of Lyell, Darwin, and Freud,” contributes new research to the diverse field mapping the intersections of science and literature in the nineteenth century. Although scholars such as Gillian Beer and George Levine have established ties between developments in the natural sciences and the scope of the nineteenth-century novel, there has not been a sustained effort to attend to the narrative structures of the primary texts that most influenced coterminous literary movements of the period. My work thus attends closely to the narrative and imaginative form of scientific …

The Trentonian (Late Ordovician) Brachiopod Fauna Of Ontario: Evolution Through A Global Warming Event, Akbar Sohrabi Hashjin

Electronic Thesis and Dissertation Repository

This thesis, which examines the evolution of the Late Ordovician (early Katian) brachiopod fauna of Ontario, consists of two main parts: 1) a case study of the Late Ordovician Rhynchotrema–Hiscobeccus lineage of North America to investigate the morphological variations and evolutionary trends of brachiopod fauna in time and space, 2) the paleobiogeography of early Katian brachiopod fauna to explore their distribution patterns at a global scale and controlling factors.

During the Katian, the North American craton experienced a first-order marine transgression. The early stage of this event in the early Katian (Trentonian, Chatfieldian) was marked by the development …