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An In Vivo Investigation Of Short-Ranged Structural Connectivity In The Human Brain, Jason Kai Sep 2022

An In Vivo Investigation Of Short-Ranged Structural Connectivity In The Human Brain, Jason Kai

Electronic Thesis and Dissertation Repository

Short-ranged connectivity comprise the majority of connections throughout the brain, joining together nearby regions and contributing to important networks that facilitate complex function and cognition. Despite constituting the majority of white matter in the brain and their importance, studies examining short-ranged connections have thus far been limited in part due to the challenges associated with identifying and validating them. Tractography, a computational technique for reconstructing axon trajectories from diffusion magnetic resonance imaging, has been commonly used to identify and study major white connections (e.g. corticospinal tract), which are easier to identify relative to the short-ranged connections. The use of additional …


Three-Dimensional Ultrasound Imaging For Characterization Of Synovitis In First Carpometacarpal Osteoarthritis, Carla Du Toit Jun 2022

Three-Dimensional Ultrasound Imaging For Characterization Of Synovitis In First Carpometacarpal Osteoarthritis, Carla Du Toit

Electronic Thesis and Dissertation Repository

First carpometacarpal osteoarthritis is one of the most common forms of OA and is a significant source of pain and disability for patients. Discrepancies between traditional imaging modalities and patient reported outcomes have led galvanized researchers to developing objective point of care based imaging tools for assessing OA progression and treatment response. This thesis aims to describe the development and validation of a semi-submerged mechanical three-dimensional ultrasound device against magnetic resonance imaging. The validation of the 3D US device was conducted on a series of imaging phantoms, as well as ten CMC1 OA patients. Two-raters manually segmented areas of synovial …


The Natural History Of Modic Changes - A 5- And 15-Year Follow-Up Study, Parnian Saremi Feb 2022

The Natural History Of Modic Changes - A 5- And 15-Year Follow-Up Study, Parnian Saremi

Electronic Thesis and Dissertation Repository

Modic changes (MCs), defined as bone marrow lesions adjacent to the vertebral endplate seen on MRI, have been associated with back pain. There are different types of MCs, with different histopathological correlates. This community-based study sample comprised 110 men from the Twin Spine Study, with baseline, 5-year, and 15-year follow-up MRIs. Following training and reliability testing, 1320 endplates (T12-S1) were evaluated for MC presence, type, and dimensions at each time point. Results demonstrated that Type 2 Modic Changes (MC2) were the most common type, with approximately half located at the two lowest disc levels. However, Type 1 Modic Changes (MC1) …


Assessment Of Tropical Cyclone Wind And Wave Hazards And Their Effect On The Reliability Of Wind Turbines, Chao Sheng Feb 2022

Assessment Of Tropical Cyclone Wind And Wave Hazards And Their Effect On The Reliability Of Wind Turbines, Chao Sheng

Electronic Thesis and Dissertation Repository

Tropical cyclone (TC) induces strong winds, heavy rainfalls, and storm surge. They cause fatalities and property damages, especially in the coastal regions that are prone to TC hazards. The TC wind or wave assessments were reported in the literature. The assessment provides the required hazard characterizations for assessing the reliability and risk of structures such as onshore and offshore wind turbines (WTs). The present study considered sites near the coastline of mainland China. It is focused on 1) the assessment of using different historical best-track datasets on the development of stochastic TC track models and on the estimated TC wind …