Digital Commons Network^™

Exploring Cognitive Maps Through Sketching, Melissa M. Nantais

Electronic Thesis and Dissertation Repository

Abstract

Periodic testing has been found to improve the accuracy of participants’ cognitive maps when an onscreen map is provided, however, it is unclear whether the same results would occur without the onscreen map. The current study investigated whether drawing a map periodically while exploring the virtual environment Silcton would improve cognitive map accuracy. Participants explored Silcton and were stopped every 4 minutes to either sketch a map of Silcton, identify items seen in Silcton, or colour an unrelated picture, and a baseline group was not stopped. All groups drew a final sketch map and completed a direction estimation task. …

Sanaugavut: Art From Kinngait, Nakasuk Alariaq

Electronic Thesis and Dissertation Repository

“Sanaugavut: Art from Kinngait” explores 20^th century Inuit art from an Inuk’s perspective to highlight the work Inuit participants contributed to in the development of commercialized art production in the North. The author Nakasuk Alariaq is from Kinngait (Cape Dorset) and is the first Inuk graduate student at Western University to be offered space within the university’s formal settings to curate an Inuit art exhibition. This exhibition and thesis go hand in hand and are therefore very important to advocates of Indigenous self-representation in academia and in galleries. The exhibition “Sanaugavut: Art from Kinngait” was …

Investigating The Role Of Atrx In Glutamatergic Hippocampal Neurons, Renee Tamming

Electronic Thesis and Dissertation Repository

Mutations in ATRX, a Snf2-type chromatin remodeler, frequently lead to intellectual disability. However, the function of ATRX within the brain in cognition and synaptic transmission are incompletely understood. The aim of this study was to investigate the role of ATRX in the adult mouse brain. While complete loss of ATRX in the embryonic mouse brain results in perinatal lethality, mosaic expression of ATRX stunted growth and perturbed circulating IGF-1 levels. Mosaic expression of ATRX also impaired adult cognition, specifically recognition memory and spatial learning and memory. However, there were confounding factors that led me to a new model in …

Effect Of Atrx Inactivation On Hippocampal Synaptic Plasticity In Mice, Radu Gugustea

Electronic Thesis and Dissertation Repository

The ATRX gene encodes an ATP-dependent chromatin remodeling factor and gene mutations cause developmental defects and intellectual disability. Conditional ablation of Atrx in mouse postnatal forebrain excitatory neurons (ATRX-KO) leads to spatial learning and memory impairments. Thus, we hypothesized that hippocampal synaptic transmission and plasticity are disrupted in ATRX-KO mice. Long-term potentiation (LTP), a cellular correlate of memory, and input-output relation of paired-pulse responses were studied in urethane-anesthetized mice in vivo. Theta-burst stimulation (TBS) of stratum oriens induced robust basal dendritic LTP in CA1 of both ATRX-KO and control mice, while paired-pulse facilitation (PPF) during baseline was lower in ATRX-KO …

Watching And Working Through: Navigating Non-Being In Television Storytelling, Tiara Lalita Sukhan

Electronic Thesis and Dissertation Repository

This dissertation explores various examples of the concept of symbolic non-being within television drama. It seeks to investigate the ways and degrees to which television storytelling can represent and perform the psychoanalytic process of “working through.” The medium of television provides a unique framework for investigation as television does not just illustrate (represent) working through as something a fictional character experiences, but it also performs it structurally, through the incorporation of three medium-specific features: duration, immersion and repetition. Television represents working through on a mass scale – imagining a collective audience by addressing big political, personal and/or institutional issues that …

The Role Of H3k4 Methyltransferases In Drosophila Memory, Nicholas Raun

Electronic Thesis and Dissertation Repository

Gene transcription required for long-term memory requires the modification of histones. However, there are still many uncertainties about the identity and spatial expression of genes regulated by histone modifications during memory related processes. In this project I examined the role of Drosophila melanogaster methyltransferases Set1 and trx in courtship memory. Genetic knockdown of Set1 and trx in the mushroom body (MB) revealed that Set1 was necessary for short- and long-term memory, while trx was only required for long-term memory. Transcriptional profiling of MBs following trx-knockdown revealed expression changes in MB-enriched genes and genes involved in RNA processing. Among the …