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Contribution Of Trpm2 To Memory Loss In An Alzheimer's Mouse Model, Megan M. Chen

Electronic Thesis and Dissertation Repository

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the progressive deterioration of memory and other intellectual abilities. Accumulation of amyloid-β (Aβ) peptide, the major contributor to the senile plaques central to AD, is thought to mediate neurotoxicity by inducing oxidative stress and calcium dysregulation. Transient Receptor Potential Melastatin type 2 (TRPM2) is a calcium permeable, non-selective cation channel activated under oxidative stress and ultimately induces cell death. The APPSWE/PSEN1ΔE9 double transgenic mouse model carries the human APPswe (Swedish mutations K594N/M595L) and PS1 mutations with a deletion in exon 9 (PS1-dE9), and is one of the most commonly used AD …

Musical Mood And Musical Arousal Affects Different Stages Of Learning And Memory Performance, Tram Nguyen

Electronic Thesis and Dissertation Repository

This thesis examined whether the effect of music on memory is attributable to musical mood, musical arousal, context, or some combination of these factors. In Experiment 1, participants performed a face-name paired-association task while music was played in the background. In Experiment 2, the perceptual context (Experiment 2A) and emotional context (Experiment 2B) of music was examined more thoroughly. Experiment 3 examined whether the context effect of musical mood and musical arousal occurs in a recall task (Experiment 3A), a recognition task (Experiment 3B), and an association task (Experiment 3C). The results showed that low arousal music enhanced memory while …

The Legacy Of Military Necessity In Italy: War And Memory In Cassino And Monte Sole, Cynthia D. Brown

Electronic Thesis and Dissertation Repository

The rise of Benito Mussolini’s Fascist party and its disastrous alliance with Nazi Germany remains one of the most well-known parts of Italy’s Second World War experience, at least in English historical literature. The war did not end when the Italians surrendered to the Allies in September 1943. Military histories of what followed focus on the bitter campaign waged between the Germans and the Allies on the Italian peninsula. Much less is known about the impact of war on the Italian nation and its civilians.

From the Italian perspective, the war was a defining yet difficult period that remains controversial …