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Structure And Thermodynamics Of Polyglutamine Peptides And Amyloid Fibrils Via Metadynamics And Molecular Dynamics Simulations, Riley Workman
Structure And Thermodynamics Of Polyglutamine Peptides And Amyloid Fibrils Via Metadynamics And Molecular Dynamics Simulations, Riley Workman
Electronic Theses and Dissertations
Aggregation of polyglutamine (polyQ)-rich polypeptides in neurons is a marker for nine neurodegenerative diseases. The molecular process responsible for the formation of polyQ fibrils is not well understood and represents a growing area of study. To enable development of treatments that could interfere with aggregation of polyQ peptides, it is crucial to understand the molecular mechanisms by which polyQ peptides aggregate into fibrils. Many experimental techniques have been employed to probe polyQ aggregation, however, observations from these studies have not lead to a unified understanding of the properties of these systems, instead yielding competing, fragmented theories of polyQ aggregation. This …
Development Of An Mrm Federation System Using Cots Simulations, Jaeho Kim
Development Of An Mrm Federation System Using Cots Simulations, Jaeho Kim
Electronic Theses and Dissertations
The goal of this research is to build an experimental environment for the Simulation Interoperability Laboratory (SIL) of the University of Central Florida (UCF). The Simulation Interoperability Laboratory (SIL) is researching about multi-resolution modeling(MRM), with a focus on military field uses. This thesis proposes steps to develop an MRM federation system and build two different MRM systems using COTS simulations (SIMBox, VR-Forces, and MASA Sword). This report is written to provide the basis for a time-based MRM federation study in the Simulation Interoperability Laboratory. The report describes many definitions and notions related to Multi-Resolution Modeling(MRM) and discusses examples to make …