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Microengineering The Neural Tube, Christopher Demers Aug 2015

Microengineering The Neural Tube, Christopher Demers

Electronic Theses and Dissertations

Early embryonic development is a complex and highly regulated orchestra of instructive cues that collectively guide naïve stem cells towards progressively more specialized fates. In the neural tube, the precursor structure to the brain and spinal cord, these signals emanate from ‘organizing centers’ surrounding the neural tube. These organizing centers send out soluble cues or morphogens that diffuse tens to hundreds of microns to recipient cells residing in the neural tube. Re-creating this dynamic landscape of cues in vitro is impossible using standard cell culture tools and techniques. However, microfluidics is perfectly suited to fill this gap, allowing precise control …


A Case Study Exploring Organizational Development And Performance Management In The Operational Infrastructure Of A Professional Working Organization, Using Academic Constructs, Wm. Casey Crear Jun 2015

A Case Study Exploring Organizational Development And Performance Management In The Operational Infrastructure Of A Professional Working Organization, Using Academic Constructs, Wm. Casey Crear

Electronic Theses and Dissertations

Curriculum, as a concept, has been historically associated with traditional schooling, but the reality is that its application extends to many arenas beyond academia. Through the case study lens, this dissertation utilized the ideologies of curricular theorists John Dewey, John Franklin Bobbitt, and Ralph Tyler to explore how intended, enacted, and assessed curricula phases can integrate into a professional working organization’s comprehensive functionality and materialize into the planning and implementation of its operational infrastructure. Following content analysis of a selected institution’s operational system, using closed codes, a descriptive comprehensive curriculum was designed to address the research purpose of understanding …


The Insecurities Of Underdevelopment: Case Studies Of Child Soldiers And Street Children, Victoria Leilani Busse Apr 2015

The Insecurities Of Underdevelopment: Case Studies Of Child Soldiers And Street Children, Victoria Leilani Busse

Electronic Theses and Dissertations

After the Cold War, a paradigm shift occurred in the study of international conflict that led to a move away from traditional state-military centric security to make human beings the referent object of security instead. This paper uses the case studies of Sierra Leonean child soldiers and Brazilian street children to explore the links between human security and development. Children are already a vulnerable population, but they are made more insecure when they live in underdeveloped states. While poverty is a main causal factor in both these phenomena, other variables contribute to these social epidemics such as: weak governing structures, …


Impact Of Development On Freshwater Turtle Populations Of Coastal South Carolina: An Examination Of Land Use And Road Density, Andre Dominguez Jan 2015

Impact Of Development On Freshwater Turtle Populations Of Coastal South Carolina: An Examination Of Land Use And Road Density, Andre Dominguez

Electronic Theses and Dissertations

Previous studies (Haxon 2000; Steen and Gibbs 2004; Marchand and Litvaitis 2004; Aresco 2005) have demonstrated that urbanization and development have disproportionally adverse affects on female turtles. In order to test this paradigm I caught 301 turtles (primarily Trachemys scripta scripta) in ten ponds (5 impacted and 5 unimpacted) across coastal South Carolina. Not only do coastal South Carolina turtles not follow the same male biased pattern of many other studies, there was an overall female bias (154:95). Turtle metrics were between the types of sites existed as well, indicating larger/older population of turtles in unimpacted sites. Water quality parameters …


The Effects Of Surf-Driven Development On The Local Population Of Playa Gigante, Nicaragua, Nicholas Harrison William Earhart Jan 2015

The Effects Of Surf-Driven Development On The Local Population Of Playa Gigante, Nicaragua, Nicholas Harrison William Earhart

Electronic Theses and Dissertations

In many of the world's developing countries, tourism is starting to play a more important role in the improvements of the local and national economies. One of these countries that have started to view tourism as a way to alleviate poverty throughout the country is Nicaragua. With miles of beaches, large swaths of pristine rainforests and beautiful volcanoes, Nicaragua has plenty to offer to travelers from all over the world. One of the sectors of tourism that has rapidly expanded in recent years is that which caters specifically to North American and European surfing tourists, who travel to Nicaragua for …


Effects Of Benzo[A]Pyrene And Cyp19a1b Knockdown On Zebrafish Development, Khalid M. Alharthy Jan 2015

Effects Of Benzo[A]Pyrene And Cyp19a1b Knockdown On Zebrafish Development, Khalid M. Alharthy

Electronic Theses and Dissertations

Benzo[a]pyrene (BaP) is a ubiquitous environmental contaminant that is both an endocrine disruptor and a carcinogen. Aromatase (CYP19) is a key enzyme in steroidogenesis playing a key role in the hypothalamus-pituitary-gonad feedback loop. We hypothesized that BaP would negatively impact cyp19a1b expression in zebrafish, in turn, adversely affecting development and physiology. Here, we consider whether the toxicities observed following BaP exposure are comparable to those following a transient morpholino (MO)-mediated CYP19a1b knockdown or exposure to an aromatase inhibitor (fadrozole) during early development. One-cell zebrafish embryos were injected with a CYP19a1b-MO or control-MO. Other non-injected embryos were exposed to nominal waterborne …


Development Of The Readiness To Teach Online Scale, Angel Chi Jan 2015

Development Of The Readiness To Teach Online Scale, Angel Chi

Electronic Theses and Dissertations

Despite the growing importance of online education, faculty acceptance has remained unchanged. Training programs developed for faculty to teach online have often focused on assessing their cognitive rather than affective and behavioral outcomes. The Readiness To Teach Online scale was developed as part of a multiphase mixed method research project to measure faculty perceptions and motivations toward teaching online. Items in the subcategory Teaching and Learning measured perceptions of technology and online teaching, and motivations regarding resources and other external factors. Items in the subcategories Social and Student Engagement, Faculty and Technology Support, Course Development and Instructional Design, and Evaluation …