Digital Commons Network^™

The Consolidation Of Memory Associations, Kyle A. Kainec

Doctoral Dissertations

Creating memories is a fundamental challenge for the human brain. To create memories, defining features of experiences must be stored distinguishably without forgetting other memories. Memory associations represent co-occurring features and defining features across experiences. Memory associations are represented as networks of information that are stored in the brain. New memory associations are encoded during experiences and can be used to update existing memory associations during offline intervals. However, the mechanisms that underlie how encoded memory associations are stored within existing networks during offline intervals remains unclear. The experiments in this dissertation address a significant theoretical gap in understanding the …

Characterizing The Roles Of The Variable Linker And Hub Domains In Camkii Activation, Noelle Dziedzic

Doctoral Dissertations

Learning and memory formation at the cellular level involves decoding complex electrochemical signals between nerve cells, or neurons. Understanding these processes at the molecular level requires a comprehensive study of calcium-sensitive proteins that serve as signal mediators within cells. More specifically, the protein calcium/calmodulin-dependent protein kinase II (CaMKII) is a key regulator of downstream cellular signaling events in the brain, playing an important role in long term memory formation. CaMKII is encoded in humans on four different genes: alpha, beta, gamma and delta. For added complexity, each of these gene products can be alternatively spliced and translated into multiple protein …

Profile-Guided Data Management For Heterogeneous Memory Systems, Matthew B. Olson

Doctoral Dissertations

Market forces and technological constraints have led to a gap between CPU and memory performance that has widened for decades. While processor scaling has plateaued in recent years, this gap persists and is not expected to diminish for the foreseeable future. This discrepancy presents a host of challenges for scaling application performance, which have only been exacerbated in recent years, as increasing demands for fast and effective data analytics are driving memory energy, bandwidth, and capacity requirements to new heights.

To address these trends, hardware architects have introduced a plethora of memory technologies. For example, most modern memory systems include …

Study Of Primary Cilia In Early Development, Pharmacology, And Brainwave Activity., Matthew Roderick Strobel

Doctoral Dissertations

The primary cilium is a unique cellular organelle that emanates from the mother centriole and extends out of the plasma membrane of nearly every mammalian cell. While originally believed to be a vestigial appendage, the cilium is now known to be a signaling hub where various intercellular communication pathways intersect to regulate morphogenesis, proliferation, polarity, differentiation, and homeostasis. Due to their importance in regulating cellular functions the cilium has become a growing focus of biomedical research as it has been linked to at least 35 human developmental disorders which have been termed ciliopathies. In the nervous system, primary cilia regulate …

There And Gone Again: Syntactic Structure In Memory, Caroline Andrews

Doctoral Dissertations

This dissertation addresses the relationship between hierarchical syntactic structure and memory in language processing of individual sentences. Hierarchical syntactic structure is a key part of human languages and language processing but its integration with memory has been uneasy ever since Sachs (1967) demonstrated that the syntactic structure of individual sentences is lost in explicit sentence recall tasks much faster than other linguistic information (lexical, semantic, etc.). Nonetheless, psycholinguists have continued to draw on memory in syntactic processing theories, in part due to (i) the explanatory power that memory can give to sentence processing hypotheses, and (ii) the conflicting results that …

A Genealogy Of Victimhood: Empathy And Memory In Recent German Fiction, Catherine E. Mcnally

Doctoral Dissertations

This dissertation addresses literary representations of empathy and altruism in Jenny Erpenbeck’s 2015 novel Gehen, Ging, Gegangen and Bodo Kirchhoff’s 2016 novel Widerfahrnis. These novels demonstrate continuities and discontinuities between German literature of the postwar, reunification and contemporary contexts.Analyzing expressions of empathy by Erpenbeck and Kirchhoff’s protagonists, I locate them in historical and literary contexts, the roots of which can be traced to the first generation of postwar German literature (1945-1968), particularly Heinrich Böll and Günter Grass. In both Grass and Böll’s early postwar fiction, German experiences of the war and its aftermath are foregrounded, and focus is placed …

Defining The Let-7 Microrna-Mediated Molecular Mechanisms Regulating T Cell Differentiation, Constance C. Angelou

Doctoral Dissertations

CD4⁺ and CD8⁺ T cells are lymphocytes of the adaptive immune system that play essential roles in immunity. Both T cell subsets recognize their cognate antigen through the T cell receptor (TCR), which induces the proliferation and differentiation of these antigen-specific cells into effector T cells. CD4⁺ T cells have the potential to differentiate into one of multiple lineages of helper T (Th) cells and participate indirectly in antigen clearance by orchestrating the function of other cells. CD8⁺ T cells differentiate into cytotoxic T lymphocytes (CTL), which directly contributes to the resolution of an infection by …

Testing The Convergent Retrieval Learning Theory Of Testing Effects, William J. Hopper

Doctoral Dissertations

What is learned from retrieving a memory that is not learned by studying the same information? In response to this question, I have proposed a new theory of retrieval-based learning in which I argue that retrieval strengthens the ability to completely activate all portions of a memory trace from an initial state of partial activation. In effect, retrieval serves to unitize the features of a memory, making the entire memory remain retrievable in the future when cue-related activation may be weaker. This theory, called the Primary and Convergent Retrieval (PCR) model, explains why practice tests produce both better long-term retention …

The Passover Seder: The History Of A Memory, Jacob F. Love

Doctoral Dissertations

The Passover Seder marks a semaphore in the history of Rabbinic Judaism. It created an unprecedented new holiday observance marking the beginning of the seven-day Passover holiday which had been observed for centuries past with various manners of fulfilling biblical requirements to abstain from leavened bread and eat bitter herbs along with the meat of the Passover offering. Throughout the period of the Second Temple, those who worshipped at the Temple understood that this required a pilgrimage to Jerusalem, the only place where sacrifice was permitted. There are hints of new thinking about the observance of such festivals in the …

The Political Work Of Memory In Collaborative Caribbean Archaeology, Elena Sesma

Doctoral Dissertations

This dissertation is the product of a community-based research project that sought to understand how descendants of the 19th century Millars Plantation on the southern end of Eleuthera, Bahamas continue to use and reinterpret the landscape that they have called home for over a century and a half. In 1871, the last owner of the Millars Plantation left the estate in her will to the descendants of her former slaves and servants. That descendant community still upholds their right to this land today, although in recent years, a Bahamian developer has attempted to gain title to the acreage through the …

Hashtag Holocaust: Negotiating Memory In The Age Of Social Media, Erica Fagen

Doctoral Dissertations

This study examines the representation of Holocaust memory through photographs on the social media platforms of Flickr and Instagram. It looks at how visitors – armed with digital cameras and smartphones – depicted their experiences at the former concentration camps of Auschwitz-Birkenau, Dachau, Sachsenhausen, and Neuengamme. The study’s arguments are twofold: firstly, social media posts about visits to former concentration camps are a form of Holocaust memory, and secondly, social media allows people from all backgrounds the opportunity to share their memories online. Holocaust memory on social media introduces a new, digital kind of memory called “filtered memory.” This study …

Recollections: Memory, Materiality, And Meritocracy At The Dr. James Still Historic Office And Homestead, Marc Lorenc

Doctoral Dissertations

The dissertation explores how memory, materiality, and meritocracy articulate together to create a meritocratic subjectivity at the Dr. James Still Historic Office and Homestead. This subjectivity frames how we experience and promote the history of Dr. James Still through an authorized heritage discourse (AHD) (Smith 2006) that promotes and re-ingrains American meritocracy, specifically the “bootstrap myth”, as a “common sense”. Using a combination of archaeological excavations, documentary analysis, and ethnography conducted under the Dr. James Still Community Archaeology Project (DJSCAP), I explore how cultural artifacts shape and influence our subjectivities at the site and more broadly in everyday interactions with …

Let-7 Mirnas Program The Fate Of Cd8 T Cells, Alexandria Wells

Doctoral Dissertations

CD8 T cells are the cytotoxic effectors of the adaptive immune response, clearing virally infected and cancerous cells within the host. CD8 T cells acquire their cytotoxic function by differentiating into cytotoxic T lymphocytes (CTLs). Once the CTLs have cleared the antigen, the majority of responding cells will die during contraction; however, a small population of the antigen-specific responders will remain, differentiating into long-lived memory cells that provide potent protection to the host upon re-encounter with the antigen. These differentiation programs often become disturbed in cases of chronic infection and cancer. Instead, CD8 T cells are subverted into the so-called …

Two Murders And A Coronation: Crusade, Crisis, And The Counts Of Flanders, 1071-1204, Bradley James Phillis

Doctoral Dissertations

The medieval counts of Flanders went on crusade with a regularity that was unmatched by the other potentates of Western Europe in the twelfth century. While the comital tradition of crusading has been noted by scholars of the crusades, it has never been carefully studied or explained. This dissertation argues that the tradition of crusading that characterized the medieval counts of Flanders developed as a political and social response to the repeated crises of the eleventh and twelfth centuries. The counts traveled east to Jerusalem in order to solidify and enhance their prestige within the county of Flanders. This tradition …

Assessing The Long-Term Sequelae Of Mild Traumatic Brain Injury, Janna Mantua

Doctoral Dissertations

A mild traumatic brain injury (mTBI), also known as a concussion, is defined as an injury that results in an alteration of consciousness or mental status. Previous studies have shown mTBI populations experience a number of chronic (> 1 year) symptoms, such as sleep disturbances (e.g., sleep stage alterations), mood alterations (e.g., depressive symptoms), and cognitive alterations (e.g., poor concentration). The three chapters of this dissertation sought to explore these long-term sequelae and the possible interrelations between them. In the first experiment, sleep-dependent memory consolidation of neutral stimuli was probed in a chronic mTBI sample and a control, uninjured sample. …

Fantasy Frontier: Old West Theme Parks And Memory In California, Amanda Tewes

Doctoral Dissertations

This study examines sites of Old West tourism—specifically the three California theme parks of Knott’s Berry Farm, Calico Ghost Town, and Frontier Village—as avenues through which the myth of “the West” gets propagated, even among the people of the American West, and even if these sites do not reflect the actual history of the region. California’s Old West theme parks act as windows into mid-twentieth-century cultural conflicts of politics and identity within the state. But these sites are artifacts of a particular historical moment and their fantasy of the Old West memorializes mid-century renderings of the past rather than nineteenth-century …

Experiencing Defeat, Remembering Victory: The Army Of Tennessee In War And Memory, 1861-1930, Robert Lamar Glaze

Doctoral Dissertations

This dissertation explores the meaning of the Civil War in the South by examining white Southerners’ perceptions of the Army of Tennessee from 1861 to 1930. While scholarship on the war’s memory is immense and growing, little of this literature examines the memory of the Confederacy's war effort in the western theater—the area of operations military historians now deem central to the war's outcome. This project rectifies that oversight by examining white Southerners’ memory of the Army of Tennessee in the post-war decades. Unlike Robert E. Lee’s Army of Northern Virginia, the Confederacy’s primary western field army suffered a near …

Lost-And-Found Photos: Practices And Perceptions, Todd J. Wemmer

Doctoral Dissertations

Personal photographs become separated from their original owners in a number of ways, due to time or tragedy, sometimes ending up in strangers’ hands. Dealers, collectors, curators, bloggers, scholars, and families actively seek what are frequently called “orphaned,” “abandoned,” or “found” photos and present them to the public in multiple formats. This dissertation offers an analysis of the practices and perceptions that surround these presentations, and it argues for use of a more inclusive term (“lost-and-found”) to describe personal photos that are connected to both finders and losers. Data were collected in three primary ways: (1) examination of the current …

Change Of Sight, Sites Of Creativity: The Visual Arts In Albania After Socialism, Sofia Kalo

Doctoral Dissertations

This dissertation examines Albania’s fine art world after the end of state socialism in 1991. Drawing on two years of anthropological fieldwork (January –August 2006 and January 2010-August 2011) in Tirana, Albania’s capital city, this study investigates how the withdrawal of state support and oversight on the arts, the introduction of a market economy and efforts toward European belonging have been reflected, responded to and challenged in the discourses and practices of aesthetic production. Viewing art as a productive site of social meaning, where people perform and struggle over their identities, their pasts and futures, this dissertation explores the social …

Melting And Crystallization Of Si And Ge2sb2te5 Nanostructures, Adam D. Cywar

Doctoral Dissertations

Recent technological advances in fabrication processes have allowed for the production of solid-state devices with dimensions as small as ~10 nm. Improving the functionality and efficiency of these devices must come from new technologies and fabrication processes. In this work, two device technologies which are driven by the thermal processes of melting and crystallization are studied in detail. A novel oscillator device concept is explored in which a Si micro-/nanowire exhibits relaxation oscillations as it switches between solid and liquid phases, resulting in large amplitude current pulses. Phase change memory (PCM), a non-volatile memory technology that shows promising scaling and …

Overcoming Violations Of Real-World Knowledge In A Fantasy-World Text, Erinn K. Walsh

Doctoral Dissertations

Fantasy-text is a genre in which events routinely violate the rules we know to be true in the real-world. In six experiments I explored the inherent conflict between unrealistic fictional events and general world knowledge (GWK) to examine these competing sources of information within the context of extended fantasy-narrative. Experiments I-III demonstrated that fantasy-unrelated violations caused measurable disruption to the comprehension of an extended fantasy narrative despite an abundance of contextual support for real-world impossible events that violate GWK. Experiments IV and V demonstrated that fantasy-related violations caused measurable disruption when they occurred at the local level and the fantasy-context …

Using Your Mind To Train Your Body: An Experimental Autobiographical Memory Intervention For Adolescent Physical Activity, Mathew Biondolillo

Doctoral Dissertations

Developmentally, physical activity levels tend to decline from adolescence to early adulthood. Adolescent physical activity programs have been largely ineffective, leading to a call for new low-cost interventions. This study examined the effects of an autobiographical memory intervention on adolescent physical activity. Over six weeks, students (N = 558) in a New England middle school completed questionnaires and were timed weekly in physical education classes while training for a school-wide race. During Week Three, some students were asked to provide a positive motivational physical activity memory and others a control memory. Students indicated their intentions to be physical active, completed …

Recreando La Imagen Literaria De La Mujer Afrodescendiente En Las Narrativas Femeninas Afrocubanas Y Afrobrasileñas Contemporáneas., Luciana Da Trindades Prestes

Doctoral Dissertations

In the XIX century, Brazil and Cuba created the abolitionist novels whose main theme emphasized black women as their main literary figure. Even though these novels aimed to denounce and depict the atrocities of the modern slavery system, the discourse of this literary corpus portrayed women of African descent under a phallocentric and racist ideology. Consequently, their image carried many negative stereotypes that have relegated them to literary and sociocultural invisibility. With this in mind, the dissertation “Recreando la imagen literaria de la mujer afrodescendiente en las narrativas femeninas afrocubanas y afrobrasileñas contemporáneas” explores how through the stimulus of a …

Crafting Memory And My Collector, Katherine Ann Davis

Doctoral Dissertations

This creative dissertation is a partial novel entitled My Collector as well as a critical introduction that explores both the usefulness of a craft essay, and how memory is rendered in fiction through the intersection of time management and point of view. In the critical introduction, I conduct close readings of two of John Banville’s novels—The Sea and The Untouchable—and apply ideas about time and memory from essays by Maud Casey, Joan Silber, and Adam Braver. My explorations demonstrate that the role of memory in fiction is more than setting up a cause-and-effect or a simple explanation for …

The Influence Of Central Thalamus On Coding Properties Of Prefrontal Cortex, Benjamin Aaron Wormwood

Doctoral Dissertations

Medial thalamus has reciprocal connections with prefrontal cortex (PFC) that are thought to coordinate its activity with other areas of the telencephalon that support flexible goal-directed behavior. The mediodorsal nucleus is the primary source of specific thalamo-cortical projections to middle layers of PFC while midline and intralaminar nuclei provide modulatory inputs to deep and superficial layers of PFC and to anatomically-related areas of the basal ganglia and hippocampus. Each of these nuclei receive direct cortico-thalamic and indirect cortico- striato-pallidal input from PFC. Medial thalamic lesions impair flexible goal-directed behavior, exemplified by delayed non-matching to position tasks (DNMTP).

To elucidate the …

The Role Of Napping On Memory Consolidation In Preschool Children, Laura Kurdziel

Doctoral Dissertations

Nocturnal sleep has been shown to benefit memory in adults and children. During the preschool age range (~3-5 years), the distribution of sleep across the 24-hour period changes dramatically. Children transition from biphasic sleep patterns (a nap in addition to overnight sleep) to a monophasic sleep pattern (only overnight sleep). In addition, early childhood is a time of neuronal plasticity and pronounced acquisition of new information. This dissertation sought to examine the relationship between daytime napping and memory consolidation in preschool-aged children during this transitional time. Children were taught either a declarative or an emotional task in the morning, and …

Effects Of Aging On Sleep-Dependent Consolidation Of Declarative Memory, Bengi Baran

Doctoral Dissertations

Sleep plays a critical role in memory consolidation. However, aging is associated with changes in sleep architecture and memory impairments. The goal of the present study was to identify age-related changes in the memory function of sleep by investigating sleep-dependent changes in neural activation patterns during memory retrieval in young and older adults. Healthy young (21-29 years) and older (62-74 years) adults were trained on a declarative word-pair learning task. Recall was tested 5 hr later while undergoing functional magnetic resonance imaging (fMRI). Participants completed this testing procedure twice, separated by 1 week; once following a mid-day nap and once …

The Genealogy Of Dislocated Memory: Yugoslav Cinema After The Break, Dijana Jelaca

Doctoral Dissertations

This dissertation analyzes the post-conflict cinema in the region of the former Yugoslavia, and the way that this particular form of cultural production establishes affective regimes within which bearing witness to trauma becomes variously articulated to national identity, history, politics, and memory. Using affect and trauma theories as organizing frameworks, my project looks at the way in which post-Yugoslav cinema has become a pivotal outlet for the process of working through the trauma of recent violent history in the region. I examine this process through its various iterations, from its applications to identity - be it ethnic, national, class, age, …

Beyond The Battlefield: Direct And Prosthetic Memory Of The American War In Viet Nam, Susan L. Eastman

Doctoral Dissertations

“Beyond the Battlefield: Direct and Prosthetic Memory of the American War in Viet Nam” examines shifts in American, Viet Namese, and Philippine memorial, literary, and cinematic remembrance of the war through the cultural lenses of later wars: the Gulf War (1990-1991) and the “War on Terror” that began in 2001. As opposed to earlier portrayals of the American War in Viet Nam (1964-1975), turn-to-the-twenty-first-century representations engage in an ever-broadening collected cultural memory—a compilation of multifaceted, sometimes competing, individual and group memories—of the war. “Beyond the Battlefield” begins with the Vietnam Veterans Memorial (1982) because it serves as the impetus for …

Rightly Or For Ill: The Ethics Of Remembering And Forgetting, Alison Nicole Reiheld '93

Doctoral Dissertations

Forgetting a birthday, a wedding anniversary, a beloved child's school play or a dear colleague's important accomplishments is often met with blame, whereas remembering them can engender praise. Are we in fact blameworthy or praiseworthy for such remembering and forgetting? When ought we to remember, in the ethical sense of 'ought'? And ought we in some cases to allow ourselves to forget?

These are the questions that ground this philosophical work. In fact, we so often unreflectively assign moral blame and praise to ourselves and others for memory behaviors that this faculty, and moral responsibility for it, deserve careful philosophical …