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Biological Activities Of Influenza Virus Subpopulations: Characterization Of Infectious, Interferon-Inducing And Interferon Induction-Suppressing Particles, Christopher P. Malinoski
Biological Activities Of Influenza Virus Subpopulations: Characterization Of Infectious, Interferon-Inducing And Interferon Induction-Suppressing Particles, Christopher P. Malinoski
Doctoral Dissertations
This dissertation explores the complex nature of the influenza virus quasispecies. Influenza populations exist as a mixture of mostly replication-deficient biologically-active particles. These particles are measured and quantified based upon the phenotype they manifest upon entry into the host. Three subpopulations are characterized: infectious, interferon-inducing, and interferon induction-suppressing particles.
It has been observed that only 5 out of every 100 particles of influenza are infectious. A novel biological assay was developed and, for the first time, directly demonstrated that infectious particles are the progenitors of all other virus particles. From the disparity observed to exist between the numbers of physical …