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Generation Of Diverse Molecular Complexity From Cyclooctatetraene, Mohamed Fawzy El Mansy
Generation Of Diverse Molecular Complexity From Cyclooctatetraene, Mohamed Fawzy El Mansy
Dissertations (1934 -)
ABSTRACT
GENERATION OF DIVERSE MOLECULAR COMPLEXITY
FROM CYCLOOCTATETRAENE
Mohamed F. El Mansy, B.Sc, M.Sc.
Marquette University, 2014
The use of simple hydrocarbons as starting materials for the synthesis of complex molecules relies on efficient methods for oxidation, functionalization or rearrangement. For example, various researchers have explored cyclopentadiene or cycloheptatriene as precursors for the preparation of a wide variety of drug candidates, natural products and synthetic products. The purpose of this research is to explore methods to transform the simple hydrocarbon, cyclooctatetraene (COT) into complex target molecules.
Tricarbonyl (cyclooctatetraene)iron, readily prepared from COT, reacts with a variety of electrophiles to form …