Digital Commons Network^™

Pre-Stimulus Anticipation And Unconscious Fear Learning Disparities In Individuals With Varying Levels Of Anxiety, Anastasiya Rumyantseva Kharlamova

Dissertations, Theses, and Capstone Projects

The current study employed a Pavlovian conditioning paradigm to investigate the influence of pre-stimulus unconscious threat anticipation on subsequent fear responses in associative learning. Additionally, we explored the differences in pre-stimulus anticipation among individuals with varying levels of anxiety. Electrodermal response (EDA) was chosen as a primary measure due to its robustness in fear conditioning paradigms. Moreover, the State-Trait Anxiety Inventory (STAI) was utilized to assess anxiety levels in participants. Twenty-seven subjects were recruited to determine if pre-stimulus skin conductance responses (SCR) would exhibit stimulus-specific patterns influenced by implicit cues (L-shaped configurations) that indicated an upcoming face or a house …

Competitive And Facilitative Interactions Between Pavlovian Cues In Human Associative Learning: A Behavioral And Neural Analysis, Fahd Alhazmi

Dissertations, Theses, and Capstone Projects

Learning to anticipate significant events accurately is a crucial element of survival for all species. The process by which animals acquire this knowledge has been a central question of psychological research. A fundamental assumption of many learning theories is that the predictive value assigned to cues is not simply determined by their probability of reinforcement but rather by their ability to compete with other cues present during learning. The assumption of cue competition has significantly contributed to the development of behavioral and neuroscience research for decades, as it has opened the door to new empirical and theoretical advances on the …

Investigating Steady State Visually Evoked Potentials As A Novel Biosignature For Anxiety-Related Attention Bias, Elizabeth R. Davis

Dissertations, Theses, and Capstone Projects

Anxiety-related attention bias (AB), a type of cognitive bias underlying the development and maintenance of anxiety disorders, is typically defined as exaggerated attention towards threat; however, some individuals also demonstrate AB away from threat and in some instances, no detectable AB at all. Debate about the reliability and validity of AB behavioral measures has prompted examination of additional assessment methods. Neurophysiological methods, such electroencephalography (EEG), have yielded encouraging early findings. The steady-state visually evoked potential (SSVEP), a measure of selective visual attention derived from EEG, holds promise as a biosignature for AB. Research documents heightened SSVEP power to emotionally salient …

Learning To Feel Safe: A Translational Study Of The Influence Of Safety Learning On Anxiety-Related Overgeneralized Fear, Hyein Cho

Dissertations, Theses, and Capstone Projects

Anxiety disorders are among the most common mental health diagnoses, affecting about a third of the population in their lifetime. However, approximately a third of individuals with anxiety do not respond to current treatment approaches, highlighting the need to identify additional potential therapeutic mechanisms. Safety learning is one such mechanism, but methodological challenges and a dearth of research have prevented the field from advancing the understanding of the role of safety learning in the etiology and remediation of anxiety disorders. Animal research, using single-cued safety learning paradigms, has yielded promising early findings, demonstrating that safety learning directly reduces anxiety-related behaviors …

Targeting Ampa Receptor Modulation During Early Life Adversity: A Mediator For Threat Associated Memories, Roseanna M. Zanca

Dissertations, Theses, and Capstone Projects

Early life adversity (ELA) is the exposure to a single or to multiple traumatic events before the age of 18 that go beyond the child’s coping. These adverse events are often exacerbated during adolescence particularly when cognitive performance is compromised. Adolescents who experienced ELA may show symptoms of post-traumatic stress disorder (PTSD), while not vividly recalling the early life trauma. These individuals show atypical connectivity between prefrontal-amygdala and hippocampus, all of which is associated with an increased risk of experiencing a traumatic event again later in life. While clinical research has increasingly stressed the importance in addressing the long-lasting consequences …

The Impact Of Racial Microaggressions And Major Discriminatory Events On Mental Health, Florence Lui

Dissertations, Theses, and Capstone Projects

The current study, a secondary data analysis, sought to determine the number and nature of latent groups for experiences of spectrum racial discrimination (i.e., both major and microaggressive racial discrimination) in a sample of emerging adults from a people of color (POC)-majority public university setting in the United States, and to understand the role of socio-demographic variables in defining each group. In addition, the study aimed to ascertain the extent to which endorsing spectrum racial discrimination experiences predicted anxiety and/or depression above the effects of general, non-race-related stress. Finally, the analyses gauged the mediating and/or moderating role of coping in …

Diet, Inflammation, Gut Microbiome, And Mental Health, Ashley R. Polokowski

Dissertations, Theses, and Capstone Projects

Omega-3 fatty acids (ω-3 FAs) are an essential fatty acid necessary for healthy development in mammals. They possess anti-inflammatory properties and have more recently been shown to impact gut microbiota, both factors hypothesized to be associated with depression and anxiety. Thus, empirical efforts have begun to examine the benefit of ω-3 FAs as a treatment option for various psychological disorders. Although there is evidence that ω-3 FAs have favorable outcomes on depressive symptoms, the relationship between ω-3 FAs and anxiety and the pathways by which ω-3 FAs produce beneficial health effects are poorly understood. Both inflammation and the gut microbiome …

The 5-Ht1a-R Knockout Mouse As A Model Of Later Life Anxiety Disorders: Implications For Sex Differences, Tatyana Budylin

Dissertations, Theses, and Capstone Projects

Anxiety affects nearly twice as many women as it affects men across all cultures and economic groups. Importantly, girls have a higher chance of inheriting anxiety disorders than boys, and many anxiety disorders appear at a very young age. However, little is known about sex differences in brain and behavioral development and how they relate to anxiety in adulthood. Serotonin 1A receptor (5-HT_1A-R) mediated signaling has been implicated in depression and anxiety, however most studies that focus on the involvement of the 5-HT_1A-R have been conducted in adults. Little is known about how the 5-HT_{1A …}

Ck2 Negatively Regulates 5-Ht4 Receptor Signaling In The Prefrontal Cortex And Mediates Depression-Like Behaviors, Julia Castello Saval

Dissertations, Theses, and Capstone Projects

The serotonergic system has been the major candidate in the pathophysiology of mood related disorders such as anxiety and major depressive disorder (MDD). Unfortunately, current antidepressant drugs are ineffective in 50% of the population and require chronic administration for a period of 3-6 weeks before the onset of therapeutic response. 5-HT4 receptor (5-HT₄R) agonists have emerged as potential candidates for fast antidepressant action, since an antidepressant response can be achieved after 3 days of pharmacological administration in rodents.

This dissertation aims to investigate the role of casein kinase 2 (CK2) as a regulator of 5-HT₄R expression …

Novel Biobehavioral Methods For Assessing The Anxiety-Related Attention Bias, Samantha Denefrio

Dissertations, Theses, and Capstone Projects

Anxiety disorders will affect an estimated one in three Americans, significantly impacting emotional health and quality of life. High personal and economic costs make research on the etiology, maintenance, and treatment of anxiety a crucial public health goal. Selective and exaggerated attention towards threat, termed attention bias (AB), has been identified as a core behavioral and neurocognitive mechanism in anxiety. A novel treatment, attention bias modification training (ABMT), targets AB and aims to ameliorate anxiety. Rarely acknowledged, however, are the challenges in the conceptualization and measurement of AB. First, associations between anxiety and AB in anxious populations have been increasingly …

Threat-Related Attentional Bias In Relation To Anxiety And Depressive Symptoms In The General Population: The Potential Role Of Sex Effects, Beril Yaffe

Dissertations, Theses, and Capstone Projects

Heightened sensitivity to relevant environmental stimuli (attentional bias) has been observed in relation to clinical and non-clinical anxiety and depression symptoms. While depression symptoms are associated with sensitivity to disorder and self-relevant words, hypervigilance to threatening stimuli is observed in relation to anxiety symptoms. Furthermore, attentional bias has been shown to play an important role in the development and maintenance of depressive and anxiety disorders. Accordingly, a large body of literature has examined threat-related attentional bias in relation to symptoms of anxiety and depression. However, several methodological inconsistencies exist across studies, including variability in definitions of threat, lack of consideration …

Physiological Correlates Of Affective Decision-Making In Anxiety And Depression, Louisa I. Thompson

Dissertations, Theses, and Capstone Projects

Improving our understanding of cognitive and physiological profiles in anxiety and depression has the potential to reveal novel ways to target and improve treatments for these prevalent mental health conditions. The present study examined the impact of self-reported anxiety and depression symptoms on three established decision-making measures, the Iowa Gambling Task (IGT; Bechara, Damasio, Damasio, & Anderson, 1994), Balloon Analogue Risk Task (BART; Lejuez et al., 2002), and Game of Dice Task (GDT; Brand et al., 2005), in a diverse sample of 100 college students (age 18 to 35). Physiological measures of tonic heart rate variability and galvanic skin response …

Sex Differences In The Anxiety Effects Of Cannabinoids, Helen T. French

Dissertations, Theses, and Capstone Projects

Aim: Anxiety disorders are twice as common among women, and those with anxiety disorders are 2-3 times more likely to have a substance abuse disorder than the general populace. However, little data exists on the sexually dimorphic effects of cannabinoids. In male humans and rodents, low acute doses of cannabinoids are anxiolytic while high and/or chronic doses are anxiogenic. In the dose response curve (DRC), we examined whether the biphasic effects of cannabinoids observed in males are also present in females. In the CB1R antagonism study, CP55,940-induced CB1R activation was antagonized via the CB1R-selective antagonist rimonabant to test the hypothesis …

Medication Management In Pediatric Chronic Illness: Should Patient Anxiety Be Considered?, Claire J. Hoogendoorn

Dissertations, Theses, and Capstone Projects

Introduction: There is growing support that psychological symptoms can impact various aspects of disease, well-being, and medical treatment for those with a chronic illness like Crohn’s disease (CD). Yet, almost no studies have examined whether psychological symptoms can influence management or efficacy of patient medication regimens. The aims of this project were to examine whether anxiety predicted pediatric patients’ level of medication management, medication prescription changes, and corticosteroid prescription and duration.

Method: A total of 105 pediatric patients ages 8-18 (M=14.5, SD=2.3) completed a validated anxiety questionnaire during a GI office visit (baseline). Prescribed IBD …

Feminine Ideology, Relational Self-Concept, And Internalizing Symptoms In Women, Anjali George

Dissertations, Theses, and Capstone Projects

Background: Investigators have theorized that women may experience internalizing disorders such as depression and anxiety more frequently than men in part because of unique socialization processes that women undergo. One aspect of early socialization thought to contribute to women’s propensity for depression and anxiety is the way women are brought up to relate to themselves in relation to others, often placing greater importance on the needs, desires, and value of others, at times at a psychological cost to themselves. This study attempts to elucidate the relationship between gender socialization, relational self-concept, and internalizing symptoms in women.

Methods: Two hundred and …

Psychological And Psychiatric Comorbidities Associated With Tinnitus: A Systematic Review, Shanna Hymowitz

Dissertations, Theses, and Capstone Projects

The purpose of this systematic literature review was to examine the current literature evidence pertaining to the relationship between tinnitus and psychological and psychiatric comorbidities. Literature was found discussing the prevalence of tinnitus with psychological and psychiatric comorbidities, differences in self-reports, and whether the perception of tinnitus is aided with the use of psychological counseling and psychotropic medications. Relative search strings applied to Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medline Complete, and PubMed identified studies to be included in this review. (Will put total amount of studies found once collected). An assessment of all research literature found …

"I Shall Not Fear:" Secure Attachment To G-D As A Buffer Against Anxiety, Peryl Agishtein

Dissertations, Theses, and Capstone Projects

Religion has a long and mixed history in the field of psychology. Historically, some leading figures in the field viewed religion as a source of neuroses and poor mental health; others saw a more positive spiritual resource. Recently, empirical data on religion and mental health has proliferated. There is now consensus that religion is associated with lower depression. However, the link between religion and anxiety is less clear-cut. This paper proposes that a) religion can have exacerbating or alleviating effects on anxiety depending on which aspect of religion is being studied and b) the primary religious variable that affects anxiety …

Verbal Behavior In Individuals With Generalized Anxiety Disorder And Depressive Disorders, Tzachi Slonim

Dissertations, Theses, and Capstone Projects

Generalized Anxiety Disorder (GAD) and clinical depression are both internalizing disorders characterized by sustained negative affect and have mainly been studied utilizing either self-report or physiological measures. Fewer studies have focused on behavioral indices of these disorders, and little is known about their overlapping and distinct linguistic features. The present research examined the above gap in two separate studies. Study 1 synthesized previous efforts made to study the linguistic features of individuals with depression. Previous investigations found that depressed individuals evidence high proportions of I-words, high proportions of negatively-valenced words, low proportions of positively-valenced words, and high proportions of cognitive …

Internalizing Disorders In Early Childhood: Professional Development Framework For Teachers, Danielle Guttman

Dissertations, Theses, and Capstone Projects

Recent research indicates that internalizing disorders such as depression, anxiety, and posttraumatic stress disorder (PTSD) manifest in young children. Since early childhood teachers spend a substantial portion of their day with young children, it is important to examine their beliefs and behaviors surrounding these disorders. The role of the school psychologist has come to include providing support for educators such as presenting up-to-date research through professional development (PD). The current investigation implemented an intervention designed to compare different forms of PD seminars ("Information" and "Strategies") designed to increase teachers' awareness of internalizing disorders in early childhood. Ninety-nine participants comprised the …

Inter-Religious Relationships And Anxiety In The Regulation Of Automatic Inter-Religious Prejudice, Karla J. Felix

Dissertations, Theses, and Capstone Projects

Shared reality theory predicts and evidence suggests that inter-religious relationships are motivated to maintain or regulate interpersonal interactions with others. However, this motivation has been given little attention within the automatic attitude literature. This research is centered on the idea that automatic prejudice is moderated by two fundamental themes, shared reality and anxiety. These themes are reviewed to determine the degree to which participants socially tune to ingroup versus outgroup religious experimenters. In Experiment 1, automatic inter-religious attitudes toward Christian and Jewish experimenters were assessed via a subliminal prime procedure. Religious orientation (extrinsic, intrinsic) and regulation of inter-religious relationships were …

Changing Attention To Emotion: A Biobehavioral Study Of Attention Bias Modification Using Event-Related Potentials, Laura O'Toole

Dissertations, Theses, and Capstone Projects

Anxiety is characterized by an attentional bias toward threat; that is, anxious individuals will preferentially attend to threatening versus non-threatening information. Recent research has demonstrated that reducing this bias, through attention bias modification (ABMT), leads to reductions in anxious symptoms and stress reactivity. Although these effects are promising for the development of an alternative intervention for anxiety, little is known about the attentional processes underlying ABMT effects. The present research used event-related potentials (ERPs) to investigate the neurocognitive attentional processes altered by ABMT over the course of three studies. In Study 1, non-anxious participants were trained towards and away from …

Acts Of Belonging: Perceptions Of Citizenship Among Queer Turkish Women In Germany, Ilgin Yorukoglu

Dissertations, Theses, and Capstone Projects

This thesis examines how people who have multiple identifications develop a sense of belonging. It focuses on those with politicized, romanticized, and stigmatized identifications which are assumed to be in conflict with one another. My particular case is that of "queer" women of Turkish descent in Germany with Berlin as my main study site.

These people embody what is considered to be an oxymoron: being queer yet also Turkish, being a lesbian yet having a Muslim background, being of immigrant origin yet also German. In short, they are between all worlds and thus, seemingly, do not belong anywhere. Their ambiguous …