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The Impact Of Racial Microaggressions And Major Discriminatory Events On Mental Health, Florence Lui

Dissertations, Theses, and Capstone Projects

The current study, a secondary data analysis, sought to determine the number and nature of latent groups for experiences of spectrum racial discrimination (i.e., both major and microaggressive racial discrimination) in a sample of emerging adults from a people of color (POC)-majority public university setting in the United States, and to understand the role of socio-demographic variables in defining each group. In addition, the study aimed to ascertain the extent to which endorsing spectrum racial discrimination experiences predicted anxiety and/or depression above the effects of general, non-race-related stress. Finally, the analyses gauged the mediating and/or moderating role of coping in …

Clinical Characteristics And Neuroanatomical Predictors Of Acute Antidepressant Outcome For Patients With Comorbid Depression And Mild Cognitive Impairment, Jeffrey N. Motter

Dissertations, Theses, and Capstone Projects

Background: Older adults presenting with both a depressive disorder (DEP) and cognitive impairment (CI) represent a unique, understudied population. The classification of cognitive impairment severity continues to be debated though it has recently been subtyped into late (LMCI) versus early (EMCI) stages. Previous studies have found associations between treatment outcome and both cortical thickness and white matter hyperintensities (WMH), though report inconsistent directionality and affected regions. In this study, we examined baseline clinical characteristics and neuroanatomical features as prognostic indicators for older adults with comorbid DEP and CI participating in an open antidepressant trial. EMCI is hypothesized to have greater …

Diet, Inflammation, Gut Microbiome, And Mental Health, Ashley R. Polokowski

Dissertations, Theses, and Capstone Projects

Omega-3 fatty acids (ω-3 FAs) are an essential fatty acid necessary for healthy development in mammals. They possess anti-inflammatory properties and have more recently been shown to impact gut microbiota, both factors hypothesized to be associated with depression and anxiety. Thus, empirical efforts have begun to examine the benefit of ω-3 FAs as a treatment option for various psychological disorders. Although there is evidence that ω-3 FAs have favorable outcomes on depressive symptoms, the relationship between ω-3 FAs and anxiety and the pathways by which ω-3 FAs produce beneficial health effects are poorly understood. Both inflammation and the gut microbiome …

The 5-Ht1a-R Knockout Mouse As A Model Of Later Life Anxiety Disorders: Implications For Sex Differences, Tatyana Budylin

Dissertations, Theses, and Capstone Projects

Anxiety affects nearly twice as many women as it affects men across all cultures and economic groups. Importantly, girls have a higher chance of inheriting anxiety disorders than boys, and many anxiety disorders appear at a very young age. However, little is known about sex differences in brain and behavioral development and how they relate to anxiety in adulthood. Serotonin 1A receptor (5-HT_1A-R) mediated signaling has been implicated in depression and anxiety, however most studies that focus on the involvement of the 5-HT_1A-R have been conducted in adults. Little is known about how the 5-HT_{1A …}

Ck2 Negatively Regulates 5-Ht4 Receptor Signaling In The Prefrontal Cortex And Mediates Depression-Like Behaviors, Julia Castello Saval

Dissertations, Theses, and Capstone Projects

The serotonergic system has been the major candidate in the pathophysiology of mood related disorders such as anxiety and major depressive disorder (MDD). Unfortunately, current antidepressant drugs are ineffective in 50% of the population and require chronic administration for a period of 3-6 weeks before the onset of therapeutic response. 5-HT4 receptor (5-HT₄R) agonists have emerged as potential candidates for fast antidepressant action, since an antidepressant response can be achieved after 3 days of pharmacological administration in rodents.

This dissertation aims to investigate the role of casein kinase 2 (CK2) as a regulator of 5-HT₄R expression …