Digital Commons Network^™

Supporting Student Connectedness And Social Satisfaction During Recess, Elizabeth Teasdale Wells

Dissertations, Masters Theses, Capstones, and Culminating Projects

This project examines the effects of how recess preparation and reflection can be focused on providing students an opportunity to connect socially and strengthen overall happiness. By investigating the role social satisfaction plays in a child’s life during recess, educators may gain knowledge about how to foster social connectedness for every child. While most studies about recess focus on a child’s level of physical activity or negative behaviors, researchers have yet to investigate recess as a place to improve a child’s well-being and social satisfaction. This study was conducted at a public elementary school through qualitative interviews and observations. Teachers, …

Cultivating Creation: Exploring Traditional Ecological Knowledge Of Native Song, Sara Moncada

Dissertations, Masters Theses, Capstones, and Culminating Projects

Humanities scholarship, the result of millennia of deep reflection on the human condition, informs the practices and principles that structure the way we approach our investigation of the human experience. As we consider the ways in which the humanities canon shapes the relationship of what we include as “knowledge” and how we value it, the continued exploration of how meaning and value are perceived in traditional knowledge systems and their contributions to our current models of thinking and process is vital. Through an investigation of relationships between Native song and Traditional Ecological Knowledge (TEK), I explore the importance of Native …

Immortal Melancholia: A Psychoanalytical Study Of Byronic Heroes, Kathryn Frazell

Dissertations, Masters Theses, Capstones, and Culminating Projects

This culminating project examines Byronic heroes using psychoanalytic theory across four case studies in media, including classic literature, theater, film, and television. The Byronic hero is a literary archetype inspired by the poet George Gordon, Lord Byron (1788-1824). Typical characteristics include angst, arrogance, cunning intelligence, criminality, desire, passion, dominance, and otherness. The characters I have chosen to study include Mr. Rochester from Jane Eyre (1847), the Phantom from the 2004 film The Phantom of the Opera, James Bond from the 2012 film Skyfall, and Damon Salvatore from the hit television series The Vampire Diaries (2009-2017). Through examining the …

Best Practices In A Clinical Development Project Management Office (Pmo) To Achieve A Reference Standard In The Pharmaceutical Industry, Russell Guinto

Dissertations, Masters Theses, Capstones, and Culminating Projects

Medications are developed by the pharmaceutical industry starting with the discovery phase, proceeds to preclinical trials, moves into clinical trials (progressing from Phase I to Phase III), and if the data are positive, may lead to Food and Drug Administration (FDA) approval. Once approved, post-marketing surveillance for safety is required as long as the drug is marketed to consumers. This phase may also include clinical trial Phase IV studies if additional safety testing is required. This process usually takes between ten to fifteen years, with clinical development taking seven to ten years of that time (1). Clinical development can …

Chronic Cadmium Exposure Alters Erα Dependency And Drug Sensitivity Of Breast Cancer Cells, Mathew Bloomfield

Dissertations, Masters Theses, Capstones, and Culminating Projects

The global prevalence of breast cancer in women illustrates the importance of identifying factors that contribute to disease onset and progression. Endogenous and environmental agents that interact with estrogen receptor alpha (ERα) have been shown to play a role in breast cancer etiology. Evidence from epidemiological studies and animal models has suggested that cadmium, a heavy metal that can activate ERα, contributes to the development and progression of breast cancer. Additionally, our lab showed that chronic cadmium exposure altered the expression of several ERα-responsive genes and increased the malignancy of MCF7 breast cancer cells. Although these studies support cadmium’s function …

Disrupting Narratives And Narrators: A Case For Anna Deavere Smith's Work In The High School Classroom, Amy Hale

Dissertations, Masters Theses, Capstones, and Culminating Projects

Anna Deavere Smith, American actress, writer, and professor, explores racial conflicts and the nuances that contribute to dissonance and identity politics through her one- woman plays. Employing a journalistic dramatic format of her own, Smith interviews a panoply of people who play major and minor roles involving conflicts. She then brings these interviews to life on the stage. As a high English teacher, I incorporate Smith’s plays Fires in the Mirror and Twilight: Los Angeles, 1992 into my eleventh grade American literature class. In this paper, I explain why Smith’s plays help facilitate and nurture important conversations about race for …

Understanding The Learning & Advocacy Needs Of A Twice-Exceptional Student Through A Strengths-Based Lens: A Case Study In California, Lisa Krausz

Dissertations, Masters Theses, Capstones, and Culminating Projects

Twice-exceptional students possess both high ability and learning disabilities. The complex interaction of their gifts and disabilities perplexes both educators and parents. Educators often use a deficit approach when working with these learners; new research calls for multi-dimensional, strengths-based approaches to engage these students. Strengths-based approaches draw upon student strengths, interests, and talents to help address their disabilities. In this study, information was gathered from a mixed-methods, strengths-based approach to gauge a student’s strengths, interests, talents and disabilities to add to the research on traditional assessment and intervention approaches. The researcher also explored how parents’ understanding of their child aligned …

Loss Of Function Of Gene X Protects Against Α-Dicarbonyl Stress Through The Skn-1 Pathway In C. Elegans, Austin Lim

Dissertations, Masters Theses, Capstones, and Culminating Projects

Diabetes mellitus and Parkinson’s Disease (PD) are debilitating diseases that are increasing in prevalence worldwide. One potential cause of these diseases is the accumulation of advanced glycation end products (AGEs), which are macromolecules that cause irreversible damages. AGEs are a diverse group of highly oxidative byproducts produced from α-dicarbonyl compounds (α-dcs), which are highly reactive molecules that bind indiscriminately to protein and DNA and, are regulated by a conserved glyoxalase system (GLO1 and DJ-1) in humans. Utilizing the conserved glyoxalase system, we were able to establish within a C. elegans model that when this glyoxalase system is impaired, …

Survey Of Sensory Diet Use Among California Occupational Therapy Practitioners, Morganne Peterson, Allison Hunt, Emily White

Dissertations, Masters Theses, Capstones, and Culminating Projects

The purpose of this study was to examine the use of sensory diets in the field of occupational therapy. This study investigated the use of sensory diets among California occupational therapy practitioners. A mixed-methods design was used to collect data through an online survey. The survey was sent out to members of the Occupational Therapy Association of California (OTAC) and received 98 respondents within one month. Participants worked among various clinical settings and implemented sensory diets with various client populations. Practitioners reported using terms such as “sensory strategies,” “sensory tools,” and “sensory supports” which indicates an overall misunderstanding associated with …

Resilience And Protective Factors In Older Adults, Jessica Mcclain, Katelyn Gullatt, Caroline Lee

Dissertations, Masters Theses, Capstones, and Culminating Projects

Evidence suggests resilience promotes successful aging in place and protective factors promote resilience. This study sought to investigate whether or not the combination of three protective factors, physical health, social support, and self-efficacy are all of equal importance in predicting resilience among Marin County older adults, or if some individual protective factors have a greater impact on resilience than the others. Fifty-eight participants ages 62 and higher were recruited from senior community programs and personal contacts. Four self-report questionnaires were completed by the participants in this exploratory, cross-sectional, quantitative design. SPSS was used for a descriptive and multivariate analyses to …

Measuring Physiological Responses To Sensation In Typical Adults, Sarah Button, Kristen Christensen, Emily Minor

Dissertations, Masters Theses, Capstones, and Culminating Projects

Objective: Sensory processing issues can have a large negative impact on the ability to participate in daily occupations such as ADLs, access to work, school and leisure environments, and social interactions (Dunn, 2001). The evidence documenting sensory processing issues in adults is sparse. Physiological information can be used as objective evidence to support the claim that those with over-responsivity to sensations are experiencing their environment differently than the typical population. Understanding more about sensory processing in adults may lead to increased recognition of the problem and more opportunities for intervention to increase occupational participation. The purpose of this quantitative study …

Different Methodologies To Characterize And Diagnose Sickle Cell Disease In Both Developed And Developing Nations, Mohammed Alharbi

Dissertations, Masters Theses, Capstones, and Culminating Projects

Sickle cell disease (SCD) is a genetic blood disorder that causes the RBC to become sickle shaped due to a mutation in the β-globin gene encoding the protein hemoglobin. This disease causes reduced oxygen carrying capacity of RBC resulting in painful crisis, hemolytic anemia, and infection susceptibility. SCD affects around 100,000 individuals in USA alone and 14 million people globally. SCD affected individuals have high mortality rates. Early detection and constant monitoring of this disease is essential. The following review focuses on various methodologies that have emerged in the diagnosis of SCD. Also, low cost methods that can be easily …

Natural Learning Environments And The Social-Emotional Development Of Students With Sensory Processing Challenges, Denise Elizabeth West

Dissertations, Masters Theses, Capstones, and Culminating Projects

This study examined the impact of a natural learning environment on the social-emotional development of students with Autism and/or Sensory Processing Disorder. For this research, social-emotional development consisted of social behavior, communication, and participation. The elements of a traditional classroom are characterized by confinement, harsh lighting/acoustics, and other habitual triggers for sensory discomfort. A natural learning environment can provide students with natural stimuli, fresh air, natural acoustics, natural lighting, etc. Additionally, the natural learning environment fosters a connection with nature, which research shows is important for the self-discovery, self-advocacy, and self-efficacy of all humans. Considering the artificial nature of the …

High School Visual Arts And Student Civic Engagement, Benjamin Rupers

Dissertations, Masters Theses, Capstones, and Culminating Projects

A democracy is healthiest when civic engagement is valued and demonstrated by its citizens. Although many have studied ways to increase civic engagement, the relationship between civic engagement and fine art education has not been included. The purpose of this study is to identify the relationship between art education and civic engagement in a select sample of eight AP visual art students from a high school art program in Northern California, as well as identify the level of civic engagement demonstrated by the students. The students will be interviewed and evaluated according to Hauptmann (2005)’s seven elements of civic engagement …

How To Best Support Individuals Growing Up With A Special Needs Sibling, Lauren Mcdonell

Dissertations, Masters Theses, Capstones, and Culminating Projects

The purpose of this study was to understand the emotions of a neurotypically developing sibling. This study also attempted to understand how caregivers can best support the neurotypical sibling in the areas of self-concept and overall well-being. The gap is knowledge is how to better support neurotypical developing siblings specifically in the areas of self-concept and overall well-being. Three participants were interviewed to gain insight about their experiences with their special needs sibling. Participants who participated in a support group for neurotypical developing children with a SNS were surveyed to gain insight about their experiences with the support group. Through …

Stronger Together: A Case For Team Teaching In The Elementary School Setting, Jenna Christine Degan

Dissertations, Masters Theses, Capstones, and Culminating Projects

The focus of this study was to determine the impact of team teaching on teacher efficacy, burnout, and student engagement in an elementary school setting. Few if any studies have examined the relationship between team teaching and feelings of efficacy and burnout with elementary school teachers. The purpose of this study was to determine if team teaching was a viable and workable approach for teachers in the elementary school settings to develop teacher efficacy, avoid burnout, and increase student engagement. This study utilized a qualitative methodology to collect data from three participants who were team teaching at the same elementary …

Specimen Accountability Process Change In A Non-Automated Consolidated Microbiology Laboratory, Michael Monh

Dissertations, Masters Theses, Capstones, and Culminating Projects

The pre-analytical phase contributes 60-70% of total error of the total testing process (TTP) (Plebani 2006). The pre-analytical phase can be further divided into two phases; the ‘pre-preanalytical’ and ‘preanalytical’ phases, which commonly includes tasks performed outside of the laboratory walls, and tasks perform within the laboratory’s walls and control, respectively. Additionally, medical care reimbursement policies in the U.S. along with the need to efficiently produce quality results and reduce the costs to clients, has caused the microbiology lab to move from on-site to more resourcefully abundant consolidate labs (Sautter 2014). Serving many satellite facilities, it is of interest to …

Implementation Plan To Integrate The Nanosphere Verigene Assay In A High-Volume Reference Laboratory And The Anticipated Workflow Benefits To Adopting Rapid Blood Culture Testing, Sofia Nazar

Dissertations, Masters Theses, Capstones, and Culminating Projects

Laboratory processing pathways have a significant impact on the overall management of patients with sepsis. Retrieval and isolation of the suspected pathogen from a patient blood culture specimen is required for a definitive diagnosis of bacterial septicemia. Reference laboratories are high-volume facilities most often located some distance away from the collecting facility. Given the lengthy work up already required for blood culture pathogen analysis, reference laboratories must identify ways to optimize every step of the blood culture pathway in the effort to decrease turnaround time and mitigate lag time to final pathogen identification incurred by prolonged collection-to-incubation times. Rapid molecular …

So, “In Your Eyes, I Am Complete.” A Play In One Act, K. Michelle Sellers

Dissertations, Masters Theses, Capstones, and Culminating Projects

So, “In Your Eyes, I am Complete” is a one-act play and a one-woman show. I will be playing various characters such as mom, dad and sister where I will address many layers: such as cross-cultural differences, mental health and alcoholism, to name a few.

Who Died: Redefining The Elegy Through Affect And Trauma, Brittney La Noire

Dissertations, Masters Theses, Capstones, and Culminating Projects

This project introduces the claim that death literature, specifically elegies and epitaphs, do not rely on set structure or content, but rather are poetic effects of trauma and affect. Both have been defined and redefined by critical scholars, but there is still a division about their use. The beginning of the project will pull together Paul De Man, Cathy Caruth, Theresa Brennan, and Diana Fuss to apply the theoretical principle of trauma and affect transhistorically through Theocritus, John Milton, and Percy Shelley. The final portion will be an original creative collection of elegies combined with epitaphs as ending couplets about …

Preclinical Evaluation Of Matrix Metalloproteinase Inhibitors And Protein Kinase C Activators In Cell And Mouse Models Of Huntington’S Disease, Kuruwitage Madushani

Dissertations, Masters Theses, Capstones, and Culminating Projects

Huntington’s disease (HD) is an incurable genetic neurological disorder that affects 1 in 10,000 people, with no treatment that can alter the course of the disease. Neural cell death in the striatum and the cortex results from the accumulation of toxic mutant huntingtin protein (mHTT) fragments. Full length HTT is cleaved by proteases, including caspases, calpains and matrix metalloproteinases (MMPs). Previous research has also shown altered kinase signaling pathways in HD contribute to the localization of mutant huntingtin to the nucleus and to disruption of transcriptional regulation. Currently, there are no drugs that delay the onset or slow the progression …

Responsive Classroom Approach: Teachers’ Experience With Implementation, Rachael Olmanson

Dissertations, Masters Theses, Capstones, and Culminating Projects

The research in this study aims to understand the experiences of teachers as they implement a social emotional learning curriculum called, The Responsive Classroom (RC) Approach, for the first time. Further, this research inquires about the ways in which schools can best support teachers during the initial implementation phase. This qualitative study used focused interviews, surveys, and field observations to gain the perspectives of various RC teachers. Using a humanistic research approach, each focused interview was designed to encourage a safe sharing of emotions and knowledge through the use of open-ended questions. Data collected from the interviews, in conjunction with …

Determination Of The Feasibility Of Using Cell-Free Dna (Cfdna) In The Q-Clamp Kras Codon Specific Mutation Test, Manuel Garcia

Dissertations, Masters Theses, Capstones, and Culminating Projects

KRAS is a proto-oncogene which was first identified in Kirsten rat sarcoma virus. The normal KRAS protein performs an essential function in normal tissue signaling and a mutation of a KRAS gene is an essential step in the development of many cancers. Q-Clamp® KRAS codon specific mutation test is an in vitro real-time qualitative PCR assay for the detection of mutations in the targeted regions and KRAS mutation often serves as a useful marker in drug response. The Q-Clamp® KRAS codon specific mutation test experiment was performed using cell-free extracted DNA (cfDNA) instead of FFPE extracted DNA. The results of …

Targeting Mitochondrial Proline Dehydrogenase (Prodh) With A Suicide Inhibitor As A Novel Anticancer Strategy, Beatrice Becker

Dissertations, Masters Theses, Capstones, and Culminating Projects

Proline dehydrogenase (PRODH) is a p53-inducible inner mitochondrial membrane protein linked to electron transport and capable of generating mitochondrial glutamate and intracellular ATP, especially under cellular stress conditions. Among a panel of 51 human breast cancer cell lines, PRODH and glutaminase (GLS1) expression levels were found to be inversely correlated (1) implicating two independent and alternative mitochondrial pathways supplying anaplerotic glutamate for cancer cell energy production and macromolecular synthesis. Proposing PRODH to be a promising cancer therapeutic target, we compared the in vitro cellular effects of PRODH knockdown by siRNA as well as competitive (L-tetrahydrofuroic acid, THFA; or 5-oxo-2-tetrahydrofurancarboxylic acid, …

Combinational Therapy To Mitigate Α-Dicarbonyl Toxicity, Jessica Ramirez

Dissertations, Masters Theses, Capstones, and Culminating Projects

Diabetes mellitus is a metabolic disease characterized by hyperglycemia that affects 30 million children and adults in the United States alone. Patients suffering from diabetes have high concentrations of reactive α-dicarbonyls (α-DCs) like, methylglyoxal (MGO). The abundance of α-DCs form advanced glycation end products (AGEs); in turn, the accumulation of AGEs has been linked to secondary complications. Secondary complications include diabetic neuropathy, nephropathy and cardiomyopathy. A recently discovered TRPA-1-Nrf-2 pathway is a conserved mechanism in vertebrates and invertebrates that detoxifies α-DCs; however, regulators that activate the detoxification mechanism are currently unknown. Several supplement grade compounds were screened for TRPA-1-Nrf2 induced …

Determination Of Adamts13 Susceptibility In Type Iia Von Willebrand Disease, Monica Buselli

Dissertations, Masters Theses, Capstones, and Culminating Projects

von Willebrand Disease (vWD) is a bleeding disorder caused by a deficiency in von Willebrand Factor (vWF), a large glycoprotein that assists in coagulation. Specifically, large vWF multimers in the blood stream are key components in starting the coagulation cascade. vWF is cleaved by the metalloprotease ADAMTS13, regulating the multimers size, which hinders vWF’s ability to function properly. The three main types of vWD —Type I, II, and III— are not well defined, and as a result are all similarly treated with plasma-derived vWF replacement therapy. Plasma-derived vWF is a treatment that does not cure the problem but relieves the …

Poct Testing And Importance Of Operator Lock-Out, Nuha Fadlalla

Dissertations, Masters Theses, Capstones, and Culminating Projects

Point-of-Care Testing (POCT) is usually performed at the patient’s bedside by healthcare providers other than laboratory- trained professionals. Rapid growth of POCT is supported by numerous factors which include healthcare provider efficiency, improving diagnostic insight and better patient outcomes. This project study is done to make sure POCT users have adequate training to ensure and enhance the quality and patient safety. The individual performing these tests to be trained properly before he/she is approved to operate the POC devices. One method to ensure POCT operators have met the required training is the lock out approach which will not allow them …

"Or I May Live...": Meaning-Making And Mortality, Hannah Bright

Dissertations, Masters Theses, Capstones, and Culminating Projects

This project examined the ways in which dialogical processing of the fact of one’s own impending death impacts meaning-making in day-to-day life. Taking a qualitative approach, the thesis builds from five in-depth interviews and follow-up surveys with students in higher education. In reviewing the role of death education in public school settings, the study concludes that an enhanced emphasis on love of learning, creative thinking and community engagement in public education is the most effective way for educators to support students in building appropriate skillsets to create meaning in their lives, as well as in the face of their eventual …

A Change Of Heart: Internal Narratives, Forgiveness & Health, Keiko Ehret

Dissertations, Masters Theses, Capstones, and Culminating Projects

In this thesis I investigate the interconnectedness of forgiveness as a narrative, as a philosophical, religious and cultural phenomenon, and the ways in which forgiveness is increasingly being used as a vehicle for improving health and psychological well-being. By threading together how scholars in a variety of fields have approached these areas of study, we can better understand the way the interdisciplinary nature of forgiveness grants access to heal not merely relationships with others, but also our bodies, our minds, and our relationship with ourselves.

Important to my investigation is understanding that the life circumstances that prompt forgiveness consist of …

Older Adults’ Perspective: Exploring The Experience Of Owning A Guide Dog, Jeffrey Kou, Yvonne Lam, Patricia Lyons, Susan Nguyen

Dissertations, Masters Theses, Capstones, and Culminating Projects

Guide dogs have been shown to be an effective assistive device that can help older adults with low vision navigate their community and improve overall well-being. Despite vast research conducted on pet therapy and dog companionship, limited research exists on the facilitators and barriers of owning a dog guide among older adults with low vision. The purpose of this qualitative phenomenological study is to explore the facilitators and barriers of owning a guide dog as experienced by older adults with low vision participating in Guide Dogs for the Blind (GDB) organization. Data were gathered among seven participants using semi-structured phone …