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A Clinically Relevant Closed-Head Model Of Single And Repeat Concussive Injuries In The Adult Rat Using A Controlled Cortical Impact Device, Naseem Jamnia
College of Science and Health Theses and Dissertations
Recently, cases of multiple concussions, or mild traumatic brain injury, in athletes have received increased attention. Compared to single concussion (sTBI), repeat concussions (rTBI) can produce significant long-term consequences and increased risk for neurodegenerative disease. However, mechanisms underlying this difference are poorly understood and are best elucidated using an animal model. Closed-head models of rTBI have been developed in mice and juvenile rats, but few have been developed in the adult rat. To the best of our knowledge, there is no closed-head model using a commercially available device, including the Controlled Cortical Impact (CCI) device.
We developed a clinically relevant …