Digital Commons Network^™

Risk Factors For Early And Late Onset Depression And Subsequent Risk For Alzheimer's Disease And Related Dementias In An Older Adult Population, Jordan Kugler

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The Cache County Study on Memory in Aging (CCSMA) was a research study that followed 5092 participants aged 65 or older over the course of 12 years, examining risk and protective factors for dementia. One of these factors was depression history, which has evidence for a connection with dementia, such that those with a history of depression are more likely to develop dementia later in life. However, the existing literature has yet to examine sex differences, genetic and psychosocial factors that contribute to earlier or later onset of depression and how these factors in turn might later increase risk for …

Neurotrophic Factor Genetics Of Cognitive Progression And Neuropsychiatric Symptom Presentation In Alzheimer's Disease And Related Disorders, Joshua Matthew Matyi

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The Cache County Study on Memory in Aging (CCSMA) and subsequent Dementia Progression Study (DPS) were two research studies that took place in Cache County, Utah. These studies followed 5092 participants aged 65 or older for approximately 12 years and looked at risk and protective factors for dementia, including Alzheimer’s disease. One of the factors investigated was genes that are known to influence brain health, such as brain-derived neurotrophic factor (BDNF), a protein found in the brain that helps with the survival of brain cells.

BDNF genes have been shown to be associated with Alzheimer’s disease and related dementia (ADRD) …