Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 5 of 5
Full-Text Articles in Entire DC Network
Mice With Ghrh Deficiency Are Resistant To The Detrimental Health Effects Of High Fat Diet, Joseph Jablonsky
Mice With Ghrh Deficiency Are Resistant To The Detrimental Health Effects Of High Fat Diet, Joseph Jablonsky
All ETDs from UAB
According to our previous study, mice with a CRISPR/Cas9 mediated deletion of the GHRH gene have decreased bodyweight, respiratory exchange ratio (RER), energy expenditure compared to wild type animals, and increased insulin sensitivity and enhanced longevity. Calorie restriction enhances lifespan and delays multiple aging related phenotypes; however it is not known how these animals respond to nutritional stressors such as high fat diet (HFD) during the aging process. We subjected 18 month old GHRH-/- male and female mice to a high fat diet to determine differences in response to HFD in aged animals. After HFD exposure, GHRH-/- mice have increased …
Representing Motherhood And Aging In Leonora Carrington's Bird Iconography, Claire Lesar
Representing Motherhood And Aging In Leonora Carrington's Bird Iconography, Claire Lesar
All ETDs from UAB
This thesis investigates the evolution of animal representations in paintings and sculptures of Leonora Carrington (1917-2011). Writings on her early Surrealist work often draw attention to Carrington’s embrace of the horse as a representation of self. However, over her extensive career, the menagerie of animals she draws from to depict herself evolves. I suggest that Carrington’s horse is more broadly significant as a narrative model that she adapts later in her career and that Carrington’s use of bird iconography emerges as a new form to symbolize other “rebirths” or periods of transition in her life, such as motherhood and aging. …
The Role Of Protein Translation And Degradation In Aging And Alzheimer Disease Pathogenesis, Harper S. Kim
The Role Of Protein Translation And Degradation In Aging And Alzheimer Disease Pathogenesis, Harper S. Kim
All ETDs from UAB
Protein translation (PT) is an essential cellular process playing crucial roles in growth and development. PT precipitously declines with age in multiple animal species, including humans. It has been implicitly assumed that elevated PT at young ages is beneficial to health while PT ends up dropping as a passive byproduct of aging. However, whether this holds true and how dynamic fluctuations in PT over time impact aging remain unknown. In Drosophila, we show that a transient PT spike in early-adulthood drives aging by triggering dysfunction in protein homeostasis (proteostasis) at old ages. We propose the early-adulthood spike in PT to …
Characterization Of Exercise-Associated Skeletal Muscle Secreted Factors Through Aging, Dalton Chase Patterson
Characterization Of Exercise-Associated Skeletal Muscle Secreted Factors Through Aging, Dalton Chase Patterson
All ETDs from UAB
Exercise is a powerful behavioral intervention against Central Nervous System (CNS) aging1–3 and plays an essential role in maintaining healthy neurocognitive function and immune metabolism in the aging brain3. We have developed a new transgenic mouse model that moderately over-expresses transcription factor master regulator of proteostasis, Transcription Factor E-B (TFEB), in skeletal muscle (cTFEB;HSACre mice). Despite living sedentary lifestyles, our model of enhanced skeletal muscle proteostasis shows significantly ameliorated proteotoxicity, increased BDNF levels and neurogenesis while improving neurocognitive function and decreasing neuroinflammation in the aging CNS4,5. These neuroprotective effects are markedly reminiscent of those observed in the aging CNS post-exercise6,7, …
Labor Union Membership Tenure And Midlife Health: A Gendered Perspective, Clifford Ross
Labor Union Membership Tenure And Midlife Health: A Gendered Perspective, Clifford Ross
All ETDs from UAB
The benefits of labor unions have not gone unstudied. Individuals in labor unions have better access to lower cost/more substantial health insurance plans, higher quality pension plans, and better wages leading to increased lifetime earnings. Even though many of these benefits create important pathways that could lead to better health, unions have been paid little attention in health literature. Additionally, in the modern workplace Mothers are offered lower starting salaries, are perceived as less competent, and face a penalty regarding hiring, promotion, and workplace educational opportunities. Compared to men, women with children see an income gap 20 cents wider than …