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Cd5 Regulation Of T Helper Cell Differentiation And Cytokine Signaling, Donald Mcguire
Cd5 Regulation Of T Helper Cell Differentiation And Cytokine Signaling, Donald Mcguire
All ETDs from UAB
CD5 is expressed on T and B1a cells and is an important regulator of cell survival and activation. Engagement of CD5 promotes cell survival through the activation of the serine threonine kinase CK2. Mice with genetic abrogation of CD5 binding to CK2 (CD5∆CK2bd) exhibited reduced severity of experimental autoimmune encephalomyelitis that was associated with increased activation induced cell death. In addition to inhibiting cell death, CD5 activation of CK2 significantly enhances Th17 differentiation. Loss of CD5-CK2 signaling reduces the generation of Th17 cells despite an unexpected increase in pSTAT3 levels. The mechanisms of CD5's enhancement of Th17 differentiation have not …
Cd5-Dependent Ck2 Activation Is Critical For The Maintenance Of B-1a B Cells, Kevin S. Cashman
Cd5-Dependent Ck2 Activation Is Critical For The Maintenance Of B-1a B Cells, Kevin S. Cashman
All ETDs from UAB
CD5 has classically been shown to act as a negative regulator of antigen receptor signaling, however recent evidence has discerned that the CD5 molecule contains a previously undefined cytoplasmic domain which constitutively binds inactive CK2 and facilitates its activation through CD5 ligation. With the development of a mouse model which contains a micro-deletion knock-in form of CD5 which lacks the amino acids necessary to facilitate this CD5-CK2 interaction, it is now understood that CD5 plays a more significant role in cellular physiology than previously appreciated. T cells from this mouse model show increased AICD and dysregulation in T helper subset …
Therapeutic Ck2 Inhibition Attenuates Diverse Prosurvival Signaling Cascades And Decreases Cell Viability In Human Breast Cancer Cells, Gary Kenneth Gray
Therapeutic Ck2 Inhibition Attenuates Diverse Prosurvival Signaling Cascades And Decreases Cell Viability In Human Breast Cancer Cells, Gary Kenneth Gray
All ETDs from UAB
Breast cancer is the most common malignancy in women worldwide, and it remains a major cause of mortality, thus necessitating further advancements in treatment. In breast cancer, numerous cell signaling pathways are aberrantly activated in order to produce the myriad phenotypes associated with malignancy; such pathways include the PI3K/Akt/mTOR, NF-κB and JAK/STAT cascades. These pathways are highly interconnected, but one prominent lateral enhancer of each is the remarkably promiscuous kinase CK2. CK2 expression has been shown to be elevated in human cancer, thus implicating it in tumorigenesis through its effects on known oncogenic signaling cascades. In this study, differential aberrant …