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Studies Of Molecular Mechanisms Of Royal Jelly Mediated Healthspan Promotion In Caenorhabditis Elegans, Xiaoxia Wang

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Numerous studies have demonstrated that many nutraceuticals have potential capacity to mitigate the symptoms of aging and age-related disorders. We found that Royal Jelly (RJ/eRJ) consumption could extend C. elegans lifespan and increase stress tolerance in an IIS/DAF-16 dependent manner. In consideration that the transactivity of DAF-16 is tightly controlled by its co-factors, our further results indicated that SIR-2.1, 14-3-3, and HCF-1 could interact with each other to fine-tune the activity of DAF-16. Additionally, these co-factors were also required in RJ/eRJ mediated stress tolerance. Given that aging is characterized with progressively declined physiological functions, it is intriguing to investigate whether …