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Western University

2014

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The Christian As Witness In View Of The True Witness, Emily Patricia Wilton Dec 2014

The Christian As Witness In View Of The True Witness, Emily Patricia Wilton

Electronic Thesis and Dissertation Repository

This thesis examines Karl Barth’s understanding of what it means for Christian individuals to be witnesses of Jesus Christ. By analyzing the structure of Barth’s doctrine of reconciliation, with attention to his view of Jesus Christ as mediator, the thesis establishes the christological context of Barth’s concept of witness. The thesis demonstrates how Barth arrives at the conclusion that witness is central to the definition of Christian existence and identifies key features of Barth’s view of witness, namely, its theocentrism, its basis in ontology, and its enactment in human history. The thesis engages secondary scholarship in a critical appraisal of …


The Production Of Unequal Vulnerability To Flood Hazards In Metro Vancouver, Canada, Greg S. Oulahen Dec 2014

The Production Of Unequal Vulnerability To Flood Hazards In Metro Vancouver, Canada, Greg S. Oulahen

Electronic Thesis and Dissertation Repository

Flood risk is a growing concern in Canada’s cities. Residents of these cities have differential risk according to their unique vulnerability and exposure to flood hazards. Factors related to societal structural forces, human agency, and place interact to produce vulnerability to hazards. Analysis of the factors that influence vulnerability will lead to a better understanding of how unequal vulnerability to hazards is produced among residents of a city. This dissertation investigates the factors that influence vulnerability to flood hazards in a Canadian coastal urban region, Metro Vancouver. It develops and applies a conceptual framework for looking across scales and across …


Modulation Of The Cardiomyocyte Hypertrophic Responses To Endothelin-1 By Adipocytes, Suresh Chandra Bairwa Dec 2014

Modulation Of The Cardiomyocyte Hypertrophic Responses To Endothelin-1 By Adipocytes, Suresh Chandra Bairwa

Electronic Thesis and Dissertation Repository

Leptin and adiponectin are the adipokines that are shown to exert pro-hypertrophic and anti-hypertrophic effects respectively, in cardiomyocytes. We sought to determine the direct interaction between the adipocytes and cardiomyocytes during endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy and determine the role of leptin and adiponectin.

The adipose tissue conditioned medium (ACM) inhibited the ET-1-induced hypertrophy in a concentration-dependent manner and this anti-hypertrophic effect was more potent or reversed in the presence of leptin receptor antagonist (LRA; 0.1 nM) or adiponectin receptor-1 antibody (ARA; 100 ng/mL), respectively. ACM from heart failure rats induced by coronary artery ligation or obese rats did not mitigate …


The “Other” Athletes: Representations Of Disability In Canadian Print Media During The London 2012 Paralympic Games, Melinda A. Maika Dec 2014

The “Other” Athletes: Representations Of Disability In Canadian Print Media During The London 2012 Paralympic Games, Melinda A. Maika

Electronic Thesis and Dissertation Repository

In our highly mediated society, media culture plays a critical role in socialization and offers a conduit for the naturalization of ideas. By this reasoning, stories told by the media about Paralympic athletes have the potential to influence our understanding of disability. This study reveals the representation of Paralympic athletes in Canada’s two national newspapers The National Post and The Globe & Mail surrounding the London 2012 Paralympic Games. Eighty-eight articles were collected over a 40-day period from August 15, 2012 – September 23, 2012. A critical disability studies lens guided methods of media frames analysis. Results demonstrated that coverage …


An Examination Of Psychological Variables Influencing Perceptions Of The Self Among A Sample Of Female Exercise Initiates, Lisa Cooke Dec 2014

An Examination Of Psychological Variables Influencing Perceptions Of The Self Among A Sample Of Female Exercise Initiates, Lisa Cooke

Electronic Thesis and Dissertation Repository

The general purpose of this dissertation was to explore the relationship among and within cognitive variables associated with exercise initiation and maintenance in a sample of female exercise initiates.

Manuscript 1 was structured to explore the changes to exercise identity among a population of female exercise initiates (N = 78) grouped into an imagery or control condition. Previous research has found that a strong exercise identity is associated with more frequent exercise (Strachan et al., 2009) and increases over time as a person continues to exercise (Cardinal & Cardinal, 1997). Participants were assessed multiple times (weeks 0, 5, 9, …


Yaari With Angrez: Whiteness For A New Bollywood Hero, Teresa Hubel Dec 2014

Yaari With Angrez: Whiteness For A New Bollywood Hero, Teresa Hubel

Department of English Publications

This chapter comments on the relative insignificance of whiteness to Hindi film narratives, with white characters turning up, when they do, often as peripheral figures to create the effect of historical accuracy. It argues that in Hindi cinema, whiteness cannot function as it does in the West, where the legacy of imperialism has made it an unmarked category, whose invisibility allows it to function as a norm against which the aberration of racial others may be measured. In Indian films, whiteness is marked; and it is, increasingly, markedly white—to be resisted, or desired, or dismissed.


Fatal Attraction: The Fetishized Image Of The Fatal Woman As Gothic Double, Margaret Anne Young Dec 2014

Fatal Attraction: The Fetishized Image Of The Fatal Woman As Gothic Double, Margaret Anne Young

Electronic Thesis and Dissertation Repository

The Gothic heroine is often doubled by an image – a painting, statue, costume, drawing, projection, or mental image – that is preternaturally powerful and endowed with an antagonistic sexual presence. This image of the fatal woman, unlike portraits of the heroine, is a representation without a referent: a fetish object, both for fictional characters and critics.

I argue that the simulacrum of dangerous femininity is a shifting signifier rather than a one-dimensional representation of – as previous critics have argued – ‘male fears and desires’ or female empowerment. Following the work of sociologist Bruno Latour and narratologist Mieke Bal, …


Media Usage Survey: Overall Comparison Of Faculty And Students, Gerd Gidion, Michael Grosch, Luiz Fernando Capretz, Ken Meadows Dr. Dec 2014

Media Usage Survey: Overall Comparison Of Faculty And Students, Gerd Gidion, Michael Grosch, Luiz Fernando Capretz, Ken Meadows Dr.

Electrical and Computer Engineering Publications

Recent developments in the use of technologies in education have provided unique opportunities for teaching and learning. This paper describes the results of a survey conducted at Western University (Canada) in 2013, regarding the use of media by students and instructors. The results of this study support the assumption that the media usage of students and instructors include a mixture of traditional and new media. The main traditional media continue to be important, and some new media have emerged as seemingly on equal footing or even more important than the traditional forms of media. Some new media that have recently …


Motivational Interviewing Via Co-Active Life Coaching Intervention For Women Seeking A More Physically Active Lifestyle, Andrea M. Goddard Dec 2014

Motivational Interviewing Via Co-Active Life Coaching Intervention For Women Seeking A More Physically Active Lifestyle, Andrea M. Goddard

Electronic Thesis and Dissertation Repository

The purpose of this 12-week pre-post design pilot study was to assess the impact of Motivational Interviewing via Co-Active Life Coaching (MI-via-CALC) on exercise-specific self-efficacy, barrier-specific self-efficacy, self-esteem, and 12-week study duration engagement in physical activity (PA) for 25 women between the ages of 30 and 55 years. Participants were assessed quantitatively using the previously validated McAuley Exercise-Specific Self-Efficacy Scale (EXSE), McAuley Barrier-Specific Self-Efficacy Scale (BARSE), Rosenberg Self-Esteem Scale (RSES), and International Physical Activity Questionnaire (IPAQ-SF) at pre-, mid-, and post-intervention. Four one-way repeated measures ANOVAs were completed for each scale, and statistically significant differences in barrier-specific self-efficacy were detected …


Canadian Post-Secondary Students, Stress, And Academic Performance – A Socio-Ecological Approach, L. Nicole Versaevel Dec 2014

Canadian Post-Secondary Students, Stress, And Academic Performance – A Socio-Ecological Approach, L. Nicole Versaevel

Electronic Thesis and Dissertation Repository

The purpose of this integrated-article dissertation was to examine stress and health in Canadian post-secondary students. Data from the spring 2013 National College Health Assessment (NCHA) was utilized in study one and two. This dataset is comprised of 34,039 students from 34 self-selected Canadian postsecondary institutions who took part in the NCHA survey. Study one examined the impact of stress, identified stressors and predicted which students were more likely to experience stress. Stress was the most commonly identified impediment to academic performance and 57.6% of students reported more than average stress. Most frequently reported stressors include; academics, finances, and sleep …


Rural Heterosexual Female Adolescents' Decision-Making About Sexual Intercourse And Pregnancy In Ontario, Paulina Ezer Dec 2014

Rural Heterosexual Female Adolescents' Decision-Making About Sexual Intercourse And Pregnancy In Ontario, Paulina Ezer

Electronic Thesis and Dissertation Repository

Rural areas in Ontario tend to have higher rates of adolescent pregnancy. A constructivist grounded theory methodology was used to gain an in-depth understanding of rural female adolescents’ decision-making process regarding sexual intercourse and their reproductive health, and how they view rural factors and circumstances influencing this process. The adolescent sexual decision-making process that emerged from the analysis involved prioritizing four influences that affect and are affected by the rural context: personal values and circumstances, family values and expectations, friends’ influences, and community influences. Findings will improve our understanding of how rural female adolescents make choices regarding their reproductive health. …


Investigating Cortical Changes In Cervical Spondylotic Myelopathy Using Functional Magnetic Resonance Imaging, Proton Magnetic Resonance Spectroscopy And Diffusion Tensor Imaging, Izabela Kowalczyk Dec 2014

Investigating Cortical Changes In Cervical Spondylotic Myelopathy Using Functional Magnetic Resonance Imaging, Proton Magnetic Resonance Spectroscopy And Diffusion Tensor Imaging, Izabela Kowalczyk

Electronic Thesis and Dissertation Repository

Cervical spondylotic myelopathy (CSM) is the most common cause of spinal cord dysfunction in older adults. CSM can present abruptly with severe symptoms of neurological impairment or insidiously with a slow stepwise deterioration. There is no current imaging modality or biomarker that can help predict which patient will successfully respond to conservative versus surgical treatment. The goal of this thesis was to follow CSM patients longitudinally to assess how brain function, metabolism, and structure correlate to clinical outcomes in the context of recovering neurological function following surgery.

Chapter 1 of this thesis will provide a detailed literature review of the …


Media Usage In Post-Secondary Education And Implications For Teaching And Learning, Gerd Gidion, Luiz Fernando Capretz, Ken Mead Dr., Michael Grosch Dr. Dec 2014

Media Usage In Post-Secondary Education And Implications For Teaching And Learning, Gerd Gidion, Luiz Fernando Capretz, Ken Mead Dr., Michael Grosch Dr.

Electrical and Computer Engineering Publications

The Web 2.0 has permeated academic life. The use of online information services in post-secondary education has led to dramatic changes in faculty teaching methods as well as in the learning and study behavior of students. At the same time, traditional information media, such as textbooks and printed handouts, still form the basic pillars of teaching and learning. This paper reports the results of a survey about media usage in teaching and learning conducted with Western University students and instructors, highlighting trends in the usage of new and traditional media in higher education by instructors and students. In addition, the …


The Health Initiative Program For Kids (Hip Kids): Effects Of A 1-Year Multidisciplinary Lifestyle Intervention On Adiposity And Quality Of Life In Obese Children And Adolescents -- A Longitudinal Pilot Intervention Study, Dirk E. Bock, Tracy Robinson, Jamie A Seabrook, Meghan Rombeek, Kambiz Norozi, Guido Filler, Ralf Rauch, Cheril L Clarson Dec 2014

The Health Initiative Program For Kids (Hip Kids): Effects Of A 1-Year Multidisciplinary Lifestyle Intervention On Adiposity And Quality Of Life In Obese Children And Adolescents -- A Longitudinal Pilot Intervention Study, Dirk E. Bock, Tracy Robinson, Jamie A Seabrook, Meghan Rombeek, Kambiz Norozi, Guido Filler, Ralf Rauch, Cheril L Clarson

Paediatrics Publications

BACKGROUND: Though recent data suggest that multidisciplinary outpatient interventions can have a positive effect on childhood obesity, it is still unclear which program components are most beneficial and how they affect quality of life (QoL). The aim of this study was to determine if a 1-year multidisciplinary, family-centered outpatient intervention based on social cognitive theory would be effective in (i) preventing further increases in BMI and BMI z-score, and (ii) improving QoL in obese children and adolescents.

METHODS: Obese children and adolescents 8-17 years of age and their families participated in this 1-year longitudinal pilot intervention study. The intervention consisted …


Vitamin D And White Matter Abnormalities In Older Adults: A Cross-Sectional Neuroimaging Study., C Annweiler, T Annweiler, R Bartha, F R Herrmann, R Camicioli, O Beauchet Dec 2014

Vitamin D And White Matter Abnormalities In Older Adults: A Cross-Sectional Neuroimaging Study., C Annweiler, T Annweiler, R Bartha, F R Herrmann, R Camicioli, O Beauchet

Medical Biophysics Publications

BACKGROUND AND PURPOSE: Morphological brain changes related to hypovitaminosis D have been poorly studied. In particular, the age-related decrease in vitamin D concentrations may explain the onset of white matter abnormalities (WMA) in older adults. Our objectives were (i) to investigate whether there was an association between serum 25-hydroxyvitamin D (25OHD) concentration and the grade of WMA in older adults and (ii) to determine whether the location of WMA was associated with 25OHD concentration.

METHODS: One hundred and thirty-three Caucasian older community-dwellers with no clinical hydrocephalus (mean 71.6 ± 5.6 years; 43.6% female) received a blood test and a magnetic …


Enhancing Transparency Of The Research Process To Increase Accuracy Of Findings: A Guide For Relationship Researchers, Lorne Campbell, Timothy J. Loving, Etienne P. Lebel Dec 2014

Enhancing Transparency Of The Research Process To Increase Accuracy Of Findings: A Guide For Relationship Researchers, Lorne Campbell, Timothy J. Loving, Etienne P. Lebel

Psychology Publications

The purpose of this paper is to extend to the field of relationship science, recent discussions and suggested changes in open research practises. We demonstrate different ways that greater transparency of the research process in our field will accelerate scientific progress by increasing accuracy of reported research findings. Importantly, we make concrete recommendations for how relationship researchers can transition to greater disclosure of research practices in a manner that is sensitive to the unique design features of methodologies employed by relationship scientists. We discuss how to implement these recommendations for four different research designs regularly used in relationship research and …


Navigating Life With Hiv: The Lived Experiences Of Youth Living With Hiv, Tamara M M Landry Nov 2014

Navigating Life With Hiv: The Lived Experiences Of Youth Living With Hiv, Tamara M M Landry

Electronic Thesis and Dissertation Repository

Youth and young adults living with HIV, between the ages of 15 and 29 represent one-quarter of the new infection rates in Canada, but little is known about the safer sex practices, HIV disclosure processes and coping mechanisms used by this important but often neglected group to manage the every day realities of living with HIV. The primary objectives of this study were to gather qualitative data about the lived experiences of Canadian youth who are living with HIV and enhance our understanding of their experiences of becoming HIV-positive, navigating issues related to safer sex and HIV disclosure, and managing …


A Collaborative Access Control Model For Shared Items In Online Social Networks, Hanaa Al Shareef Nov 2014

A Collaborative Access Control Model For Shared Items In Online Social Networks, Hanaa Al Shareef

Electronic Thesis and Dissertation Repository

The recent emergence of online social networks (OSNs) has changed the communication behaviors of thousand of millions of users. OSNs have become significant platforms for connecting users, sharing information, and a valuable source of private and sensitive data about individuals. While OSNs insert constantly new social features to increase the interaction between users, they, unfortunately, offer primitive access control mechanisms that place the burden of privacy policy configuration solely on the holder who has shared data in her/his profile regardless of other associated users, who may have different privacy preferences. Therefore, current OSN privacy mechanisms violate the privacy of all …


Exploring Relationships Between Resume Fraud And Individual Differences, Kateryna Synyak Nov 2014

Exploring Relationships Between Resume Fraud And Individual Differences, Kateryna Synyak

Electronic Thesis and Dissertation Repository

Existing research on resume fraud highlights the commonality and consequences of resume misrepresentations, yet almost no research exists aiming to explain the occurrence of this intentional behaviour. The goal of this study was to explore the relationships between personality traits previously linked to deception (conscientiousness and honesty/humility), resume misrepresentations and acceptance of these misrepresentations. An online survey method of data collection was used during which participants constructed a resume and filled out various measures pertaining to individual difference and resume misrepresentation. The results of this study provide an initial understanding of the existing categories of resume misrepresentations and the extent …


Media Literacy And The English As A Second Language Curriculum: A Curricular Critique And Dreams For The Future, Clara R. Madrenas Nov 2014

Media Literacy And The English As A Second Language Curriculum: A Curricular Critique And Dreams For The Future, Clara R. Madrenas

Electronic Thesis and Dissertation Repository

This thesis investigates whether or not the Ontario English as a Second Language/English Literacy Development (ESL/ELD) curriculum imparts the critical literacy skills necessary for students to deconstruct the multimedia messages with which the contemporary world is saturated, in order to function as informed, agentic citizens of Ontario society. Using foundations of cultural theory, radical critical pedagogy, and critical race theory, particularly the work of James Paul Gee, Henry A. Giroux, Paulo Freire and Michael Apple, this thesis explores the ways in which the current ESL/ELD curriculum can be found lacking due to its enforcement of the banking model of education, …


Gender Relations In Hospice Palliative Home Care For Clients With Cancer And Their Family Caregivers: A Critical Analysis, Nisha S. Sutherland Nov 2014

Gender Relations In Hospice Palliative Home Care For Clients With Cancer And Their Family Caregivers: A Critical Analysis, Nisha S. Sutherland

Electronic Thesis and Dissertation Repository

The purpose of this study was to critically examine gender relations in the sociopolitical context of hospice palliative home care for clients with cancer and their family caregivers. Using a critical feminist lens, I employed critical ethnography as a methodology to uncover taken-for-granted attitudes, beliefs, and practices that shape health and health care experiences within the culture of end-of-life at home. The study addressed the following research questions: (a) How do gender relations shape health and health care experiences within the socio-political context of hospice palliative home care for clients with cancer and their caregivers?; (b) How do gendered processes …


Attachment Relationships Across Siblings And Their Common Mother: Patterns And Predictors, Kathleen Anne O'Connor Nov 2014

Attachment Relationships Across Siblings And Their Common Mother: Patterns And Predictors, Kathleen Anne O'Connor

Electronic Thesis and Dissertation Repository

Traditional attachment theory suggests that because maternal state of mind regarding attachment is generally stable by adulthood, mothers should interact similarly with their children and, consequently, should share a similar quality of attachment with each. Early empirical work, however, suggests that the quality of siblings’ relationships is frequently different. Using varied theoretical and methodological approaches, this dissertation expanded upon the existing literature to further explore the nature and underpinnings of variability in the quality of mother-infant attachment across siblings.

Study 1 comprehensively described patterns of attachment within the family, investigating the extent to which the quality of siblings’ relationships with …


Transition And Thriving In University: A Grounded Theory Of The Transition Experiences And Conceptions Of Thriving Of A Selection Of Undergraduate Students At Western University, Lisa S. Cossy Nov 2014

Transition And Thriving In University: A Grounded Theory Of The Transition Experiences And Conceptions Of Thriving Of A Selection Of Undergraduate Students At Western University, Lisa S. Cossy

Electronic Thesis and Dissertation Repository

Abstract

The transition from high school to university has been associated with decreases in health and wellbeing for some students. The purpose of this qualitative research was to explore the transitional needs and experiences of students leaving high school and entering Western University, to explore how students conceptualize thriving, and to develop a substantive theory of transition and thriving for Western University students.

A total of 42 students and 21 staff members from Western University participated in this study. Data were collected through focus groups and individual interviews. Utilizing grounded theory data analysis methods two conceptual models were developed. The …


Understanding Women's Health Promotion In Rural Canadian Churches, Robyn Plunkett Nov 2014

Understanding Women's Health Promotion In Rural Canadian Churches, Robyn Plunkett

Electronic Thesis and Dissertation Repository

Many rural health resources are linked to community churches, which are often well attended, especially by rural women. Thus, the rural church may be an effective health resource for rural Canadian women who have compromised access to health resources. Despite the significant role that the rural church plays in the life of rural communities, there is very limited research that addresses how the church acts or could act as a health resource for rural women. Furthermore, there is limited understanding of how the church as a place may influence health promotion in rural communities. This dissertation explores the relevance of …


The Contribution Of Attachment Styles And Reassurance Seeking To Daily Mood And Relationship Quality In Romantic Couples, Lyndsay E. Evraire Nov 2014

The Contribution Of Attachment Styles And Reassurance Seeking To Daily Mood And Relationship Quality In Romantic Couples, Lyndsay E. Evraire

Electronic Thesis and Dissertation Repository

Excessive reassurance seeking (ERS), defined as the stable tendency to excessively and persistently seek assurances from others, has recently emerged as a possible risk factor for interpersonal distress and depression. An important limitation in the ERS literature concerns the mechanism(s) by which individuals engage in ERS. The current daily diary study was among the first to examine the daily relationships among ERS, mood, and relationship quality in romantic couples, and explore how these associations were moderated by individual and partner attachment styles. Method: A sample of 110 heterosexual couples completed measures of attachment, ERS, symptoms of depression, and relationship quality. …


T Helper Type 2-Polarized Invariant Natural Killer T Cells Reduce Disease Severity In Acute Intra-Abdominal Sepsis, R. V. Anantha, D. M. Mazzuca, S. X. Xu, S. A. Porcelli, D. D. Fraser, C. M. Martin, I. Welch, T. Mele, S. M.M. Haeryfar, J. K. Mccormick Nov 2014

T Helper Type 2-Polarized Invariant Natural Killer T Cells Reduce Disease Severity In Acute Intra-Abdominal Sepsis, R. V. Anantha, D. M. Mazzuca, S. X. Xu, S. A. Porcelli, D. D. Fraser, C. M. Martin, I. Welch, T. Mele, S. M.M. Haeryfar, J. K. Mccormick

Paediatrics Publications

Summary: Sepsis is characterized by a severe systemic inflammatory response to infection that is associated with high morbidity and mortality despite optimal care. Invariant natural killer T (iNKT) cells are potent regulatory lymphocytes that can produce pro- and/or anti-inflammatory cytokines, thus shaping the course and nature of immune responses; however, little is known about their role in sepsis. We demonstrate here that patients with sepsis/severe sepsis have significantly elevated proportions of iNKT cells in their peripheral blood (as a percentage of their circulating T cells) compared to non-septic patients. We therefore investigated the role of iNKT cells in a mouse …


Public, Private, Popular: Pop Performers, Liberalism And The Limits Of Rights, Matt Stahl Nov 2014

Public, Private, Popular: Pop Performers, Liberalism And The Limits Of Rights, Matt Stahl

FIMS Publications

American popular music discourse and pop performers' political practice frequently give prominence to questions of rights, particularly in relation to musical property and labour. This article examines these two rights issues as they appear in popular media and in lawmaking. The article invokes the liberal division of life into "public" and "private" realms in order to explicate the mechanics of rights claims in media and legislative forums, and to explore their relationship with aspects of liberal common sense. It draws on a political-theoretical framework to problematize liberalism's basic division of life into "public" and "private" realms, and suggests that pop …


Association Of Head And Cervical Injuries In Pediatric Occupants Involved In Motor Vehicle Collisions, Shayan Shekari Oct 2014

Association Of Head And Cervical Injuries In Pediatric Occupants Involved In Motor Vehicle Collisions, Shayan Shekari

Electronic Thesis and Dissertation Repository

The leading cause of death for children in the age group of 1-14 years is accidental injury. Motor vehicle accidents make up 63% of all accidental injury deaths in this age category. Furthermore, traumatic brain injury causes the highest number of deaths among children involved in motor vehicle collisions. Although cervical spine injuries are less frequent, they do cause death in children. Using a retrospective database, the objective of this pilot study was to determine whether there was a relationship between head injuries and cervical spine injuries and if cervical spine injuries had a higher frequency in younger pediatric passengers. …


Reforming Ontario Teachers (1990-2010): The Role Of The College Of Teachers, Janice Pennycook Oct 2014

Reforming Ontario Teachers (1990-2010): The Role Of The College Of Teachers, Janice Pennycook

Electronic Thesis and Dissertation Repository

This dissertation takes up the idea of the teacher as a professional and examines the period in Ontario between 1990 and 2010 when a change in teacher governance through the creation of the College of Teachers contributed to a refocusing of teacher evaluation policy and a redefining of what it means to be a professional teacher. Across a wide variety of settings, teachers are now viewed as central to successful education reform with the result that the requisite qualities of the professional teacher and how teachers are to be transformed to achieve these qualities have become the subjects of intense …


Quantitative Mri Correlates Of Hippocampal And Neocortical Pathology In Intractable Temporal Lobe Epilepsy, Maged Goubran Oct 2014

Quantitative Mri Correlates Of Hippocampal And Neocortical Pathology In Intractable Temporal Lobe Epilepsy, Maged Goubran

Electronic Thesis and Dissertation Repository

Intractable or drug-resistant epilepsy occurs in over 30% of epilepsy patients, with many of these patients undergoing surgical excision of the affected brain region to achieve seizure control. Advances in MRI have the potential to improve surgical treatment of epilepsy through improved identification and delineation of lesions. However, validation is currently needed to investigate histopathological correlates of these new imaging techniques. The purpose of this work is to investigate histopathological correlates of quantitative relaxometry and DTI from hippocampal and neocortical specimens of intractable TLE patients. To achieve this goal I developed and evaluated a pipeline for histology to in-vivo MRI …