Digital Commons Network^™

Cognitive Decline In Thrombotic Thrombocytopenic Purpura Survivors: The Role Of White Matter Health As Assessed By Mri., F Hannan, J Hamilton, C J Patriquin, K Pavenski, M T Jurkiewicz, L Tristao, A M Owen, P K Kosalka, S C L Deoni, J Théberge, J Mandzia, S H S Huang, J D Thiessen

Department of Medicine Publications

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare condition caused by severe ADAMTS13 deficiency, leading to platelet aggregation and thrombosis. Despite treatment, patients are prone to cognitive impairment and depression. We investigated brain changes in iTTP patients during remission using advanced magnetic resonance imaging (MRI) techniques, correlating these changes with mood and neurocognitive tests. Twenty iTTP patients in remission (30 days post-haematological remission) were compared with six healthy controls. MRI scans, including standard and specialized sequences, were conducted to assess white matter health. Increased T1 relaxation times were found in the cingulate cortex (p < 0.05), and elevated T2 relaxation times were observed in the cingulate cortex, frontal, parietal and temporal lobes (p < 0.05). Pathological changes in these areas are correlated with impaired cognitive and depressive scores in concentration, short-term memory and verbal memory. This study highlights persistent white matter damage in iTTP patients, potentially contributing to depression and cognitive impairment. Key regions affected include the frontal lobe and cingulate cortex. These findings have significant implications for the acute and long-term management of iTTP, suggesting a need for re-evaluation of treatment approaches during both active phases and remission. Further research is warranted to enhance our understanding of these complexities.

The Multidimensional Symptom Index: User Manual And Questionnaire, David Walton

Physical Therapy Publications

The user manual for the MultiDimensional Symptom Index, including hard copy versions in both English and Canadian French translations.

Click here for a direct link to an online interactive version of the MSI: dwalton5.pythonanywhere.com

Exceptional Canadian Contributions To Research On Cognitive Vulnerability To Depression., David J. A. Dozois, Elizabeth P. Hayden

Psychology Publications

For more than four decades, Canadian psychologists have made significant contributions to the understanding of cognitive vulnerability to depression. This article highlights some of these exceptional contributions and the important roles Canadian scientists have played in enhancing our understanding of the cognitive products (e.g., dysfunctional attitudes), cognitive operations/processes (e.g., attention, encoding, and memory biases), and cognitive structures (i.e., cognitive organization) involved in depression. Following this review, we discuss research that has integrated cognitive vulnerability with other risk factors for depression, address some important measurement issues in cognitive vulnerability research, and highlight directions for future research. (PsycInfo Database Record (c) 2022 …

Sensory Function And Psychological Factors In Children With Complex Regional Pain Syndrome Type 1, Emma E. Truffyn, Massieh Moayedi, Stephen C. Brown, Danielle Ruskin, Emma G. Duerden

Brain and Mind Institute Researchers' Publications

Objective: To assess thermal-sensory thresholds and psychosocial factors in children with Complex Regional Pain Syndrome Type 1 (CRPS-I) compared to healthy children. Methods: We conducted quantitative sensory testing on 34 children with CRPS-I and 56 pain-free children. Warm, cool, heat, and cold stimuli were applied to the forearm. Children with CRPS-I had the protocol administered to the pain site and the contralateral-pain site. Participants completed the self-report Behavior Assessment System for Children. Results: Longer pain durations (>5.1 months) were associated with decreased sensitivity to cold pain on the pain site (P =.04). Higher pain-intensity ratings were associated with elevated …

Treatment-Resistant Major Depressive Disorder: Canadian Expert Consensus On Definition And Assessment, Yuri E. Rybak, Ka S.P. Lai, Rajamannar Ramasubbu, Fidel Vila-Rodriguez, Daniel M. Blumberger, Peter Chan, Nicholas Delva, Peter Giacobbe, Caroline Gosselin, Sidney H. Kennedy, Hani Iskandar, Shane Mcinerney, Paula Ravitz, Verinder Sharma, Ari Zaretsky, Amer M. Burhan

Paediatrics Publications

Background: Treatment-resistant depression (TRD) is a debilitating chronic mental illness that confers increased morbidity and mortality, decreases the quality of life, impairs occupational, social, and offspring development, and translates into increased costs on the healthcare system. The goal of this study is to reach an agreement on the concept, definition, staging model, and assessment of TRD. Methods: This study involved a review of the literature and a modified Delphi process for consensus agreement. The Appraisal of Guidelines for Research & Evaluation II guidelines were followed for the literature appraisal. Literature was assessed for quality and strength of evidence using the …

Depressive Cognition On Twitter., David J A Dozois

Psychology Publications

No abstract provided.

Is Postpartum Depression A Clinically Useful Concept?, Verinder Sharma

Paediatrics Publications

No abstract provided.

The Importance Of Social Connectedness: From Interpersonal Schemas In Depression To Relationship Functioning And Well-Being, David J. A. Dozois

Psychology Publications

In this article, a program of research is described, which began with a focus on depression. A number of studies have demonstrated that negative self-schemas, particularly for interpersonal content, are well organized and appear to represent stable vulnerability factors for depression. Fortunately, this negative interpersonal structure is also modifiable through effective treatments (both psychological and pharmacological). An important extension of this research has involved investigating the impact of schemas on interpersonal phenomena (e.g., excessive reassurance seeking) and the formation of schemas about others (e.g., romantic partners). The dyadic partner-schema model, which articulates how self- and partner-schemas impact relationship functioning, is …

Anxiety And Depression In Canada During The Covid-19 Pandemic: A National Survey., David J. A. Dozois, Mental Health Research Canada

Psychology Publications

Depression and anxiety are the most prevalent mental health problems in Canada. The COVID-19 pandemic will likely result in a large increase in the incidence and prevalence of anxiety and depression and experts are already warning of an “echo pandemic” of mental health problems. The objective is this research was to explore how Canadians are managing with the COVID-19 outbreak and determine the impact of the pandemic on levels of anxiety and depression. A nationally representative sample of 1,803 participants completed an online survey that was offered in both official languages. The percentage of respondents who indicated that their anxiety …

Diffusion Dispersion Imaging: Mapping Oscillating Gradient Spin-Echo Frequency Dependence In The Human Brain., Aidin Arbabi, Jason Kai, Ali R Khan, Corey A Baron

Brain and Mind Institute Researchers' Publications

PURPOSE: Oscillating gradient spin-echo (OGSE) diffusion MRI provides information about the microstructure of biological tissues by means of the frequency dependence of the apparent diffusion coefficient (ADC). ADC dependence on OGSE frequency has been explored in numerous rodent studies, but applications in the human brain have been limited and have suffered from low contrast between different frequencies, long scan times, and a limited exploration of the nature of the ADC dependence on frequency.

THEORY AND METHODS: Multiple frequency OGSE acquisitions were acquired in healthy subjects at 7T to explore the power-law frequency dependence of ADC, the "diffusion dispersion." Furthermore, a …

Concordance Between Health Administrative Data And Survey-Derived Diagnoses For Mood And Anxiety Disorders, J. Edwards, A. Thind, S. Stranges, M. Chiu, Kelly K. Anderson

Epidemiology and Biostatistics Publications

Objective: To assess whether estimates of survey structured interview diagnoses of mood and anxiety disorders were concordant with diagnoses of these disorders obtained from health administrative data.

Methods: All Ontario respondents to the 2012 Canadian Community Health Survey-Mental Health (CCHS-MH) were linked to health administrative databases at ICES (formerly known as the Institute for Clinical Evaluative Sciences). Survey structured interview diagnoses were compared with health administrative data diagnoses obtained using a standardized algorithm. We used modified Poisson regression analyses to assess whether socio-demographic factors were associated with concordance between the two measures.

Results: Of the 4157 Ontarians included in our …

Neural Activity During Self-Referential Processing In Children At Risk For Depression., Pan Liu, Matthew R J Vandermeer, Marc F Joanisse, Deanna M Barch, David J A Dozois, Elizabeth P Hayden

Psychology Publications

BACKGROUND: According to cognitive theories of depression, more negative and less positive self-schemas are thought to play a causal role in the disorder. Existing evidence speaks to the neural substrates of self-referential processes in both healthy and depressed individuals, but little is known about how the brain relates to self-referential processing in the context of depression risk in children. We therefore studied the neural substrates of self-referential processing in never-depressed preadolescent children at high and low risk for depression based on maternal depression history.

METHODS: A total of 87 never-depressed 10-12-year-old children (29 with maternal depression) completed a self-referential encoding …

Women's Freedom Of Movement And Participation In Psychosocial Support Groups: Qualitative Study In Northern India, Nicola Gailits, Kaaren Mathias, Elysée Nouvet, Pooja Pillai, Lisa Schwartz

Health Studies Publications

© 2019 The Author(s). Background: Depression, the world's leading cause of disability, disproportionately affects women. Women in India, one of the most gender unequal countries worldwide, face systemic gender disadvantage that significantly increases the risk of common mental disorders. This study's objective was to examine the factors influencing women's participation in psychosocial support groups, within an approach where community members work together to collectively strengthen their community's mental health. Methods: This community-based qualitative study was conducted from May to July 2016, across three peri-urban sites in Dehradun district, Uttarakhand, Northern India. Set within an NGO-run mental health project, data were …

A Randomized Controlled Trial Of Internet-Delivered Cbt And Attention Bias Modification For Early Intervention Of Depression, R. Mcdermott, David J. A. Dozois

Psychology Publications

Abstract

The conceptualization and empirical knowledge base related to major depression has increased dramatically in recent years. We now have well-developed and validated models of depression from a range of theoretical perspectives. These models have significantly enhanced the development of effective treatments and preventative interventions. Although various prevention programs are available, Web-based protocols can enhance accessibility to evidence-based prevention programs. The current study involved a randomized controlled trial focused on the prevention and treatment of depression in high-risk first- and second-year undergraduate students. Three Internet-delivered preventative programs were compared: cognitive behavioral therapy (CBT; MoodGym), attentional bias modification, and an active …

Changes In Depression And Positive Mental Health Among Youth In A Healthy Relationships Program, Natalia Lapshina, Claire Crooks, Amanda Kerry

Journal Articles

Mental health promotion programming in schools and community settings is an important part of a comprehensive mental health strategy. The goal of this study was to identify and explore meaningful classes of youth based on their pre- and post-intervention depression symptoms scores with 722 youth involved in a 15-week healthy relationships and mental health promotion program. We utilized latent class growth analysis to identify depression class trajectories, controlling for group clustering effects. A three-class solution identified high decreasing, moderate stable, and low stable trajectories. Gender, age, and reported experience of bullying victimization predicted trajectory class membership. The low stable class …

Who Is At Risk For Problematic Video Gaming? Risk Factors In Problematic Video Gaming In Clinically Referred Canadian Children And Adolescents, Chloe Lau, Shannon L. Stewart, Catalina Sarmiento, Donald H. Saklofske, Paul F. Tremblay

Paediatrics Publications

Both Internet and offline video gaming have become a normal aspect of child development, with estimates of children playing video games ranging from 90% to 97%. Research on problematic video gaming (PVG) has grown substantially in the last decade. Much of that research has focused on community samples, while research on clinically referred children and youth is lacking. The present study includes 5820 clinically referred children and youth across 44 mental health agencies, assessed using the interRAI Child and Youth Mental Health Assessment. Logistic regression analyses revealed that older age, male sex, extreme shyness, internalizing symptoms, externalizing symptoms, and poor …

Beneficial Pleiotropic Antidepressive Effects Of Cardiovascular Disease Risk Factor Interventions In The Metabolic Syndrome, Stephanie J. Frisbee, Sarah S. Singh, Dwayne N. Jackson, Kent A. Lemaster, Samantha A. Milde, J. Kevin Shoemaker, Jefferson C. Frisbee

Bone and Joint Institute

© 2018 The Authors. Background--Although the increased prevalence and severity of clinical depression and elevated cardiovascular disease risk represent 2 vexing public health issues, the growing awareness of their combined presentation compounds the challenge. The obese Zucker rat, a model of the metabolic syndrome, spontaneously develops significant depressive symptoms in parallel with the progression of the metabolic syndrome and, thus, represents a compelling model for study. The primary objective was to assess the impact on both cardiovascular outcomes, specifically vascular structure and function, and depressive symptoms in obese Zucker rats after aggressive treatment for cardiovascular disease risk factors with long-term …

The Contribution Of Health And Psychological Factors In Patients With Chronic Neck Pain And Disability: A Cross-Sectional Study, Pavlos Bobos, Goris Nazari, Stephania Palimeris, Evdokia Billis, Joy C. Macdermid

Bone and Joint Institute

© 2018, Journal of Clinical and Diagnostic Research. All rights reserved. Introduction: One approach to reduce the burden of neck pain is the management of the prognostic factors that are associated with greater disability. Studies which quantify these predictors can support interventions that attempt to modify these trajectories. Aim: The aim of the present study to determine the contribution of psychological and health factors that are commonly associated with neck pain and disability levels. Materials and Methods: Patients between 18-65 years old were recruited to participate in the present study if they had neck pain for more than three months, …

Are "Stress Busters" The Solution? Teaching Wellness At The Academic Library, Emily Carlisle

FIMS Publications

No abstract provided.

Mental Disorder In Children With Physical Conditions: A Pilot Study, Alexandra Butler, Ryan J Van Lieshout, Ellen Louise Lipman, Harriet L Macmillan, Andrea Gonzalez, Jan Willem Gorter, Kathy Georgiades, Kathy N Speechley, Michael H Boyle, Mark A Ferro

Paediatrics Publications

Objectives

Methodologically, to assess the feasibility of participant recruitment and retention, as well as missing data in studying mental disorder among children newly diagnosed with chronic physical conditions (ie, multimorbidity). Substantively, to examine the prevalence of multimorbidity, identify sociodemographic correlates and model the influence of multimorbidity on changes in child quality of life and parental psychosocial outcomes over a 6-month follow-up.

Design

Prospective pilot study.

Setting

Two children's tertiary-care hospitals.

Participants

Children aged 6-16 years diagnosed in the past 6 months with one of the following: asthma, diabetes, epilepsy, food allergy or juvenile arthritis, and their parents.

Outcome Measures

Response, …

Correlates Of Poor Mental Health In Early Pregnancy In Obese European Women, Matteo C. Sattler, Judith G.M. Jelsma, Annick Bogaerts, David Simmons, Gernot Desoye, Rosa Corcoy, Juan M. Adelantado, Alexandra Kautzky-Willer

Paediatrics Publications

Background: Depression during pregnancy is associated with higher maternal morbidity and mortality, and subsequent possible adverse effects on the cognitive, emotional and behavioral development of the child. The aim of the study was to identify maternal characteristics associated with poor mental health, in a group of overweight/obese pregnant women in nine European countries, and thus, to contribute to better recognition and intervention for maternal depression. Methods: In this cross-sectional observational study, baseline data from early pregnancy (< 20 weeks) of the DALI (Vitamin D and Lifestyle Intervention for gestational diabetes mellitus prevention) study were analyzed. Maternal mental health was assessed with the World Health Organization Well-Being Index (WHO-5). Women were classified as having a low (WHO-5 ≤ 50) or high wellbeing. Results.: A total of 735 pregnant women were included. The prevalence of having a low wellbeing was 27.2%, 95% CI [24.0, 30.4]. Multivariate analysis showed independent associations between low wellbeing and European ethnicity, OR = .44, 95% CI [.25,.77], shift work, OR = 1.81, 95% CI [1.11, 2.93], insufficient sleep, OR = 3.30, 95% CI [1.96, 5.55], self-efficacy, OR = .95, 95% CI [.92,.98], social support, OR = .94, 95% CI [.90,.99], and pregnancy-related worries (socioeconomic: OR = 1.08, 95% CI [1.02, 1.15]; health: OR = 1.06, 95% CI [1.01, 1.11]; relationship: OR = 1.17, 95% CI [1.05, 1.31]). Conclusions: Mental health problems are common in European overweight/obese pregnant women. The identified correlates might help in early recognition and subsequent treatment of poor mental health problems during pregnancy. This is important to reduce the unfavorable effects of poor mental health on pregnancy outcomes. Trial registration:ISRCTN70595832 , 02.12.2011.

Obstructive Sleep Apnea And Psychiatric Disorders: A Systematic Review, Madhulika A. Gupta, Fiona C. Simpson

Paediatrics Publications

Study Objectives: Obstructive sleep apnea (OSA) has been associated with psychiatric pathology. Psychiatric comorbidity in OSA may affect patient quality of life and adherence to CPAP. A focused evaluation of OSA in highly selected groups of primarily psychiatric patients may provide further insights into the factors contributing to comorbidity of OSA and psychopathology. The goal of this study is to examine the prevalence and treatment of OSA in psychiatric populations. Methods: A systematic review following the PRISMA guidelines was conducted to determine the prevalence of OSA in schizophrenia and other psychotic disorders, mood disorders, and anxiety disorders, and to examine …

A Systematic Review Of The Association Between Psychiatric Disturbances And Endometriosis, Carley J. Pope, Verinder Sharma, Sapna Sharma, Dwight Mazmanian

Paediatrics Publications

Objective: An association between endometriosis and psychiatric disturbances has been identified by some researchers. The purpose of this systematic review was to consolidate existing empirical findings to clarify the association between endometriosis and psychiatric conditions. Data Sources: We searched three electronic databases (Medline/PubMed, Psychlnfo, and ClinicalTrials.gov) using the following search items: "endometriosis" combined with "mood," "bipolar disorder," "major depressive disorder," "anxiety," "psychiatric," "psychosocial," "antidepressants," "antianxiety," "pharmacotherapy," or "psychotherapy.". Study Selection: We included all relevant articles published in English. We identified 18 original research studies examining the association between endometriosis and psychiatric symptoms, with a combined total of 999 endometriosis patients …

Stability Of Self-Referent Encoding Task Performance And Associations With Change In Depressive Symptoms From Early To Middle Childhood., Brandon L Goldstein, Elizabeth P Hayden, Daniel N Klein

Brain and Mind Institute Researchers' Publications

Depressed individuals exhibit memory biases on the self-referent encoding task (SRET), such that those with depression exhibit poorer recall of positive, and enhanced recall of negative, trait adjectives (referred to as positive and negative processing biases). However, it is unclear when SRET biases emerge, whether they are stable, and if biases predict, or are predicted by, depressive symptoms. To address this, a community sample of 434 children completed the SRET and a depressive symptoms measure at ages 6 and 9. Negative and positive processing exhibited low, but significant, stability. At ages 6 and 9, depressive symptoms correlated with higher negative, …

Core Beliefs And Self-Schematic Structure In Depression, David J.A. Dozois, Katerina Rnic

Psychology Publications

This article reviews recent research on core beliefs (i.e., early maladaptive schemas; EMS) and self-schema structure in depression. The empirical research supports these variables as vulnerability factors for depression. Whereas EMS operate independently of stress, cognitive organization appears to influence depression in a manner consistent with a diathesis-stress model. Recent research has also explored predictors of EMS and schema structure. Specifically, childhood adversity (e.g., emotional maltreatment, peer rejection) are associated with negative self-schemas and core beliefs. Schema beliefs and structure also mediate the relation between early adversity and subsequent depression. Fortunately, these deeper cognitions appear to be modifiable by psychological …

The Neural Correlates Of Regulating Positive And Negative Emotions In Medication-Free Major Depression, Steven G. Greening, Elizabeth A. Osuch, Peter C. Williamson, Derek G. V. Mitchell

Anatomy and Cell Biology Publications

Depressive cognitive schemas play an important role in the emergence and persistence of major depressive disorder (MDD). The current study adapted emotion regulation techniques to reflect elements of cognitive behavioural therapy (CBT) and related psychotherapies to delineate neurocognitive abnormalities associated with modulating the negative cognitive style in MDD. Nineteen non-medicated patients with MDD and 19 matched controls reduced negative or enhanced positive feelings elicited by emotional scenes while undergoing functional magnetic resonance imaging. Although both groups showed significant emotion regulation success as measured by subjective ratings of affect, the controls were significantly better at modulating both negative and positive emotion. …

If It Be Love Indeed Tell Me How Much: Early Core Beliefs Associated With Excessive Reassurance Seeking In Depression., Lyndsay E. Evraire, David J. A. Dozois

Psychology Publications

This study explored core beliefs associated with excessive reassurance seeking (ERS) in depression. Undergraduate students (n = 303) completed measures of early maladaptive schemas, attachment styles, ERS, and depression, along with a subsequent measure of depressive symptoms 6 weeks later. Anxious attachment, avoidant attachment, and an abandonment/instability schema each added to the prediction of ERS beyond the effects of depression. Moreover, avoidant attachment and the abandonment/instability schema moderated the relationship between ERS and depression over time. These results are consistent with the idea that individuals with early core beliefs reflecting insecurity in relationships seek reassurance. The findings also suggest …

Cognitive Structure And Processing During Cognitive Behavioral Therapy Vs. Pharmacotherapy For Depression, Lena C. Quilty, David J. A. Dozois, Daniela S.S. Lobo, Lakshmi N. Ravindran, Michael L. Bagby

Psychology Publications

Background: Evidence has converged to suggest that cognitive processing and content covary with depression severity, whereas indices of cognitive structure exhibit greater stability and promise as markers of vulnerability for depression. The objective of the current study was to investigate the temporal dynamics and causal role of cognitive structure and processing in treatment for depression. Method: A total of 104 patients with major depressive disorder were randomized to receive cognitive behavioral therapy (CBT; n = 54) or pharmacotherapy (n = 50). Patients completed the Hamilton Depression Rating Scale (HAM-D), Beck Depression Inventory-II (BDI-II), Psychological Distance Scaling Task (PDST), Redundancy …

Catechol-O-Methyltransferase Gene Val158met Polymorphism And Depressive Symptoms During Early Childhood, Haroon I. Sheikh, Katie R. Kryski, Heather J. Smith, Lea R. Dougherty, Daniel N. Klein, Sara J. Bufferd, Shiva M. Singh, Elizabeth P. Hayden

Paediatrics Publications

Catechol-O-Methyltransferase (COMT) is a critical regulator of catecholamine levels in the brain. A functional polymorphism of the COMT gene, val158met, has been linked to internalizing symptoms (i.e., depression and anxiety) in adolescents and adults. We extended this research by investigating whether the val158met polymorphism was associated with childhood symptoms of depression and anxiety in two independent samples of young children (Ns=476 and 409). In both samples, preschool-aged children were genotyped for the COMT val158met polymorphism. Symptoms of psychopathology were assessed via parent interviews and primary caregiver reports. In both samples, children homozygous for the val allele had higher levels of …

2013-2 The Fisher Relation In The Great Depression And The Great Recession, David Laidler

Economic Policy Research Institute. EPRI Working Papers

No abstract provided.