Digital Commons Network^™

Is It Time To Stop Teaching Bystanders Ventilation As Part Of Pediatric Cardiopulmonary Resuscitation?, Allan De Caen, Janice A. Tijssen

Paediatrics Publications

No abstract provided.

Assessment Of Interdisciplinary Contributions To African Society, Serena Virani

Community, Equity, Gender

No abstract provided.

An Rb-Ezh2 Complex Mediates Silencing Of Repetitive Dna Sequences, Charles A. Ishak, Aren E. Marshall, Daniel T. Passos, Carlee R. White, Seung J. Kim, Matthew J. Cecchini, Sara Ferwati, William A. Macdonald, Christopher J. Howlett, Ian D. Welch, Seth M. Rubin, Mellissa R.W. Mann, Frederick A. Dick

Paediatrics Publications

Repetitive genomic regions include tandem sequence repeats and interspersed repeats, such as endogenous retroviruses and LINE-1 elements. Repressive heterochromatin domains silence expression of these sequences through mechanisms that remain poorly understood. Here, we present evidence that the retinoblastoma protein (pRB) utilizes a cell-cycle-independent interaction with E2F1 to recruit enhancer of zeste homolog 2 (EZH2) to diverse repeat sequences. These include simple repeats, satellites, LINEs, and endogenous retroviruses as well as transposon fragments. We generated a mutant mouse strain carrying an F832A mutation in Rb1 that is defective for recruitment to repetitive sequences. Loss of pRB-EZH2 complexes from repeats disperses H3K27me3 …

Bronchodilators For The Prevention And Treatment Of Chronic Lung Disease In Preterm Infants, Geraldine Ng, Orlando Da Silva, Arne Ohlsson

Paediatrics Publications

Background: Chronic lung disease (CLD) occurs frequently in preterm infants. Bronchodilators have the potential effect of dilating small airways with muscle hypertrophy. Increased compliance and tidal volume and decreased pulmonary resistance have been documented with the use of bronchodilators in infants with CLD. Therefore, bronchodilators might have a role in the prevention and treatment of CLD. Objectives: To determine the effect of bronchodilators given as prophylaxis or as treatment for CLD on mortality and other complications of preterm birth in infants at risk for or identified as having CLD. Search methods: On 2016 March 7, we used the standard strategy …

End-Capping Strategies For Triggering End-To-End Depolymerization Of Polyglyoxylates, Bo Fan, John Trant, Elizabeth Gillies

Chemistry Publications

Polymers that undergo end-to-end depolymerization in response to the cleavage of a stimuli-responsive end-cap are promising for diverse applications from drug delivery to responsive coatings and plastics. It is critical that the end-cap is designed to respond to an appropriate stimulus for the application. In the current work, end-caps for triggering the depolymerization of poly(ethyl glyoxylate) (PEtG) were explored. First, a phenylboronate, a disulfi de, and an azobenzene were utilized to impart redox-responsive properties to PEtG. Then, methoxy-substituted trityl groups were used to provide sensitivity to mild acid. A multiresponsive platform was also introduced, allowing PEtG to respond to multiple …

The Left Hand Doesn't Know What The Right Hand Is Doing—Or Does It?, Jody C. Culham

Brain and Mind Institute Researchers' Publications

In this issue of Cell Reports, Ossmy and Mukamel (2016) show that virtual reality enhances learning of new motor sequences through practice with one hand and synchronous feedback of the other hand moving. The approach holds promise for motor rehabilitation.

On Reckoning, Kim Solga

Department of English Publications

How can settler-colonial subjects bear witness to survivors of Canada’s residential school system? Kim Solga attends ARTICLE 11’s Reckoning at the Theatre Centre and asks questions about the strategies it uses to bring audiences into the conversation about truth and reconciliation.

The Defining Dna Methylation Signature Of Floating-Harbor Syndrome, Rebecca L. Hood, Laila C. Schenkel, Sarah M. Nikkel, Peter J. Ainsworth, Guillaume Pare, Kym M. Boycott, Dennis E. Bulman, Bekim Sadikovic

Paediatrics Publications

Floating-Harbor syndrome (FHS) is an autosomal dominant genetic condition characterized by short stature, delayed osseous maturation, expressive language impairment, and unique facial dysmorphology. We previously identified mutations in the chromatin remodeling protein SRCAP (SNF2-related CBP Activator Protein) as the cause of FHS. SRCAP has multiple roles in chromatin and transcriptional regulation; however, specific epigenetic consequences of SRCAP mutations remain to be described. Using high resolution genome-wide DNA methylation analysis, we identified a unique and highly specific DNA methylation "epi-signature" in the peripheral blood of individuals with FHS. Both hyper and hypomethylated loci are distributed across the genome, preferentially occurring in …

Mobilising Expertise And Resources To Close The Radiotherapy Gap In Cancer Care., D Rodin, J Longo, T Sherertz, M M Shah, O Balagun, N Wendling, Jacob Van Dyk, C N Coleman, M J Xu, S Grover

Oncology Publications

Closing the gap in cancer care within low- and middle-income countries and in indigenous and geographically isolated populations in high-income countries requires investment and innovation. This is particularly true for radiotherapy, for which the global disparity is one of the largest in healthcare today. New models and paradigms and non-traditional collaborations have been proposed to improve global equity in cancer control. We describe recent initiatives from within the radiation oncology community to increase access to treatment, build the low- and middle-income countries' radiation oncology workforce, mobilise more professionals from within high-income countries and raise awareness of the global need for …

Student Recital, Renee Mackenzie

All Don Wright Faculty of Music Concert Programs

No abstract provided.

Analysis Of Global Radiotherapy Needs And Costs By Geographic Region And Income Level., E Zubizarreta, Jacob Van Dyk, Y Lievens

Oncology Publications

Recent years have seen various reviews on the lack of access to radiotherapy often based on geographic regions of the world such as Africa, Asia Pacific, Europe, Latin America and North America. Countries are often defined by their national income per capita levels based on World Bank definitions of high income, upper middle income, lower middle income and low income. Within the world regions, there are significant variations in gross national income (GNI) per capita among the different countries, and even within similar income levels, large variations exist. This report presents the actual status of radiotherapy and analyses the current …

Experiences Of Caregivers Of Children With Inherited Metabolic Diseases: A Qualitative Study, Shabnaz Siddiq, Brenda J. Wilson, Ian D. Graham, Monica Lamoureux, Sara D. Khangura, Kylie Tingley, Laure Tessier, Pranesh Chakraborty, Doug Coyle, Sarah Dyack, Jane Gillis, Cheryl Greenberg, Robin Z. Hayeems, Shailly Jain-Ghai, Jonathan B. Kronick, Anne Marie Laberge, Julian Little, John J. Mitchell, Chitra Prasad, Komudi Siriwardena, Rebecca Sparkes, Kathy N. Speechley, Sylvia Stockler, Yannis Trakadis, Sarah Wafa, Jagdeep Walia

Paediatrics Publications

Background: We sought to understand the experiences of parents/caregivers of children with inherited metabolic diseases (IMD) in order to inform strategies for supporting patients and their families. We investigated their experiences regarding the management of disease, its impact on child and family life, and interactions with the health care system. Methods: From four Canadian centres, we conducted semi-structured telephone interviews with parents/caregivers of children with an IMD who were born between 2006 and 2015 and who were participating in a larger cohort study. Participants were selected with the aim of achieving a diverse sample with respect to treatment centre, IMD, …

Student Recital, Ariane Meredith, Olena Bratishko

All Don Wright Faculty of Music Concert Programs

No abstract provided.

Profiles Of Fatigue Severity And Variability Among Adolescents And Young Adults With Cerebral Palsy, Laura K. Brunton, Doreen J. Bartlett

Physical Therapy Publications

Background: Individuals with cerebral palsy (CP) experience progressive changes in functional status with the development of secondary impairments such as fatigue. Detailed accounts of the fatigue experience in CP are lacking.

Purpose: This study describes the severity and variability of fatigue in CP using the Fatigue Impact and Severity Self-Assessment.

Methods: This was a descriptive cross-sectional study surveying 130 (61 males) individuals (mean age 18 years, 11 months; SD four years, six months) with CP. Analyses comprised comparisons between two groups (Gross Motor Function Classification System (GMFCS) I and II-V), frequency counts and proportions.

Results: Significant differences exist between GMFCS …

Art History & Mass Media: The Role Of Architecture In Narrative, Jacqueline Grassi

2017 Undergraduate Awards

Art history and visual culture is portrayed by popular media in various contexts, from blockbuster to documentary, and approached through vastly different methods, ranging from the perpetuation of popular myth to academic commentary. A dichotomy arises between representations of art history from the perspective of scholarly research and the appropriation of art history as a source for creative inspiration. A veritable academic approach is perceived to depict an accurate, factual engagement with visual culture, yet large crowds bring commercial success to sensational re-imaginings of history, despite an awareness of a removal from historical truth. However, this notion that there is …

Development Of A Brief Measure Of Intimate Partner Violence Experiences: The Composite Abuse Scale (Revised)-Short Form (CasR-Sf), Marilyn Ford-Gilboe, C. Nadine Wathen, Colleen Varcoe, Harriet L. Macmillan, Kelly Scott-Storey, Tara Mantler, Kelsey Hegarty, Nancy Perrin

Nursing Publications

Objectives: Approaches to measuring intimate partner violence (IPV) in populations often privilege physical violence, with poor assessment of other experiences. This has led to underestimating the scope and impact of IPV. The aim of this study was to develop a brief, reliable and valid self-report measure of IPV that adequately captures its complexity. Design: Mixed-methods instrument development and psychometric testing to evolve a brief version of the Composite Abuse Scale (CAS) using secondary data analysis and expert feedback. Setting: Data from 5 Canadian IPV studies; feedback from international IPV experts. Participants: 31 international IPV experts including academic researchers, service providers …

Macrocephaly And Right Arm Disuse In A 7-Month-Old Boy, Michael D. Staudt, Jason D. Morgenstern, Andrea Neufeld, Adrianna Ranger

Paediatrics Publications

No abstract provided.

Newborn With Scalp Swelling, Jade Séguin, Charisse Kwan

Paediatrics Publications

No abstract provided.

Pregnant Women's Perceptions Of Exposure To Brominated Flame Retardants, A. Lane, C. G. Goodyer, F. Rab, J. M. Ashley, S. Sharma, A. Hodgson, J. Nisker

Paediatrics Publications

Background: Recent media reports on human studies associating brominated flame retardants (BFRs) in household products in pregnancy with urogenital anomalies in boys and endocrine disruption in both sexes. We sought to explore the perceptions of pregnant women of brominated flame retardant (BFR) exposure, in light of recent media reports on the adverse health effects of BFR exposure prenatally. Methods: Pregnant women were recruited for interviews through posters and pamphlets in prenatal clinics, prenatal fairs and community centres. Interviews were audiotaped and transcribed verbatim for Charmaz-based qualitative analysis supported by NVIVO 10™. Results: Theoretical sufficiency was reached after analyzing the interviews …

The Association Between Social Cohesion And Physical Activity In Canada: A Multilevel Analysis, Calvin Yip, Sisira Sarma, Piotr Wilk

Paediatrics Publications

Although previous research has shown that social cohesion may promote physical activity, social cohesion at the individual level was not always differentiated from social cohesion at the community level, and studies were often limited to specific population subgroups or geographical areas. We addressed the above limitations through the use of a multilevel modelling approach and nationally-representative data from the 2009–2014 Canadian Community Health Survey. Physical activity level was operationalized as average daily energy expenditure; social cohesion was assessed by self-rated sense of belonging to the local community; and communities were represented by Canada's Forward Sortation Areas. The sample included 245,150 …

Ablation De L'Endomètre Dans La Prise En Charge Des Saignements Utérins Anormaux, Philippe Laberge, Nicholas Leyland, Ally Murji, Claude Fortin, Paul Martyn, George Vilos

Paediatrics Publications

No abstract provided.

Atp2c2 Is Transcribed From A Unique Transcriptional Start Site In Mouse Pancreatic Acinar Cells, Melissa A. Fenech, Caitlin M. Sullivan, Lucimar T. Ferreira, Rashid Mehmood, William A. Macdonald, Peter B. Stathopulos, Christopher L. Pin

Paediatrics Publications

Proper regulation of cytosolic Ca2+ is critical for pancreatic acinar cell function. Disruptions in normal Ca2+ concentrations affect numerous cellular functions and are associated with pancreatitis. Membrane pumps and channels regulate cytosolic Ca2+ homeostasis by promoting rapid Ca2+ movement. Determining how expression of Ca2+ modulators is regulated and the cellular alterations that occur upon changes in expression can provide insight into initiating events of pancreatitis. The goal of this study was to delineate the gene structure and regulation of a novel pancreas-specific isoform for Secretory Pathway Ca2+ ATPase 2 (termed SPCA2C), which is encoded from the Atp2c2 gene. Using Next …

Detection Of Α-Thalassemia By Using Multiplex Ligation-Dependent Probe Amplification As An Additional Method For Rare Mutations In Southern Turkey, Ozge Ozalp Yuregir, Akif Ayaz, Sinem Yalcintepe, Sezin Canbek, Didar Yanardag Acik, Basak Taburoglu Yilmaz, Tugce B. Balci

Paediatrics Publications

α-thalassemia is the most common single gene disorder in the Cukurova Region in Turkey. It is therefore routinely screened, including premaritally, in our region. The heterogeneous molecular basis of the disease makes α-thalassemia mutation detection difficult and complex. Besides well established methods, multiplex ligation dependent probe amplification (MLPA) is known as an effective, simple and specific method for the detection and characterization of deletions and duplications. We employed MLPA testing to 30 patients with hematological parameters suggestive of α-thalassemia carrier status but was negative for α-thalassemia with conventional reverse dot blot hybridization (RDB). We found α-globin gene deletions in 3 …

Characterization And Immunomodulatory Effects Of Canine Adipose Tissue- And Bone Marrow-Derived Mesenchymal Stromal Cells, Keith A. Russell, Natalie H.C. Chow, David Dukoff, Thomas W.G. Gibson, Jonathan La Marre, Dean H. Betts, Thomas G. Koch

Paediatrics Publications

Background Mesenchymal stromal cells (MSC) hold promise for both cell replacement and immune modulation strategies owing to their progenitor and non-progenitor functions, respectively. Characterization of MSC from different sources is an important and necessary step before clinical use of these cells is widely adopted. Little is known about the biology and function of canine MSC compared to their mouse or human counterparts. This knowledge-gap impedes development of canine evidence-based MSC technologies. Hypothesis and Objectives We hypothesized that canine adipose tissue (AT) and bone marrow (BM) MSC (derived from the same dogs) will have similar differentiation and immune modulatory profiles. Our …

Integrin-Linked Kinase And Elmo2 Modulate Recycling Endosomes In Keratinocytes, Ernest Ho, Iordanka A. Ivanova, Lina Dagnino

Paediatrics Publications

The formation of tight cell-cell junctions is essential in the epidermis for its barrier properties. In this tissue, keratinocytes follow a differentiation program tightly associated with their movement from the innermost basal to the outer suprabasal layers, and with changes in their cell-cell adhesion profile. Intercellular adhesion in keratinocytes is mediated through cell-cell contacts, including E-cadherin-based adherens junctions. Although the mechanisms that mediate E-cadherin delivery to the plasma membrane have been widely studied in simple epithelia, this process is less well understood in the stratified epidermis. In this study, we have investigated the role of Engulfment and Cell Motility 2 …

Freeze Tolerance Of Cyphoderris Monstrosa (Orthoptera: Prophalangopsidae), Jantina Toxopeus, Jacqueline Lebenzon, Alexander H. Mckinnon, Brent J. Sinclair

Biology Publications

The great grig, Cyphoderris monstrosa Uhler (Orthoptera: Prophalangopsidae), is a large (20-30 mm, >1 g), nocturnal ensiferan that in habits montane coniferous forests in northwestern North America. C. monstrosa overwinters as a late-instar nymph, but its cold tolerance strategy has not previously been reported. We collected nymphs from near Kamloops, British Columbia, in late spring to determine their cold tolerance strategy. C. monstrosa nymphs were active at low temperatures until they froze at -4.6 ± 0.3 °C. The nymphs survived internal ice formation (i.e. are freeze tolerant), had a lethal temperature between -9 and -12 °C, and could survive for …

A Qualitative Examination Of Women's Self-Presentation And Social Physique Anxiety During Injury Rehabilitation, Molly V. Driediger, Carly D. Mckay, Craig R. Hall, Paul S. Echlin

Paediatrics Publications

Objective To understand women's self-presentation experiences in the rehabilitation setting, and their attitudes and preferences toward the social and physical features of the rehabilitation environment. Design Qualitative study. Setting Outpatient physiotherapy clinic. Participants Ten women (age 18 to 64) with high social physique anxiety (Social Physique Anxiety Scale score ≥25) referred for physiotherapy following acute injury. Main outcome measures Semi-structured interviews were conducted prior to commencement of treatment, and again after a third treatment session. Results Participants experienced extensive self-presentational concerns that were intensified due to the nature of the physiotherapy environment. The women reported that their self-presentational anxiety did …

Can The New Ckd-Epi Btp-B2m Formula Be Applied In Children?, Guido Filler, Ana Catalina Alvarez-Elías, Katherine D. Westreich, Shih Han S. Huang, Robert M. Lindsay

Paediatrics Publications

Although measuring creatinine to determine kidney function is currently the clinical standard, new markers such as beta-trace protein (BTP) and beta-2-microglobulin (B2M) are being investigated in an effort to measure glomerular filtration rate more accurately. In their recent publication, Inker et al. (Am J Kidney Dis 2015; 67:40–48) explored the use of these two relatively new markers in combination with some commonly available clinical characteristics in a large cohort of adults with chronic kidney disease. Their research led them to develop three formulae using BTP, B2M, and a combination of the two. The combined formula is particularly attractive as it …

Five-Year Publication Rate Of Clinical Presentations At The Open And Closed American Shoulder And Elbow Surgeons Annual Meeting From 2005–2010, J. Kay, M. Memon, D. De Sa, A. Duong, N. Simunovic, G. S. Athwal, O. R. Ayeni

Bone and Joint Institute

© 2016, The Author(s). Background: The purpose of this study was to evaluate the five-year publication rate of papers presented at both the open and closed American Shoulder and Elbow Surgeons’ (ASES) annual meetings from 2005 to 2010. Methods: Online abstracts of the presentations at the open and closed ASES annual meetings were independently screened for clinical studies and graded for quality using level of evidence. The databases PubMed (MEDLINE), Ovid (MEDLINE), and EMBASE were comprehensively searched for full-text publications corresponding to these presentations and any paper published within five years of the presentation date was counted. Results: Overall, 131/266 …

Western University (No. 10 Canadian Stationary Hospital And No. 14 Canadian General Hospital): A Study Of Medical Volunteerism In The First World War, Alexandra C Lstl, Vivian C. Mcalister

Office of Military Academic Medicine

The Canadian government depended on chaotic civilian volunteerism to staff a huge medical commitment during the First World War. Offers from Canadian universities to raise, staff and equip hospitals for deployment, initially rejected, were incrementally accepted as casualties mounted. When its offer was accepted in 1916, Western University Hospital quickly adopted military decorum and equipped itself using Canadian Red Cross Commission guidelines. Staff of the No. 10 Canadian Stationary Hospital and the No. 14 Canadian General Hospital retained excellent morale throughout the war despite heavy medical demand, poor conditions, aerial bombardment and external medical politics. The overwhelming majority of volunteers …